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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, HSP70, HSC70, CAN, Hsp90
Papers using CHIP antibodies
Protection by glia-conditioned medium in a cell model of Huntington disease
Mena Maria Angeles et al., In PLoS Currents, 2011
... Mouse monoclonal anti-HSP-70 and rabbit polyclonal anti-CHIP antibodies were from Santa Cruz Biotechnology (Heidelberg, Germany) ...
Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
Vandenberghe Wim et al., In The European Journal of Neuroscience, 1999
... anti-α-tubulin was from Sigma; rabbit anti-α-tubulin and anti-β-tubulin and goat anti-synphilin-1 were from Abcam; rabbit anti-CHIP was from Calbiochem; rabbit anti-Rpn10 (anti-PSMD4) was from Abgent; rabbit anti-14-3-3η was from ...
Papers on CHIP
BMP-6 inhibits the metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression.
Zhang et al., Tangshan, China. In Oncol Rep, Jan 2016
Importantly, the results of luciferase and CHIP assays revealed that BMP-6 inhibited MMP-1 promoter activity through the AP-1 response element.
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I.
Cao et al., Beijing, China. In J Immunol, Jan 2016
Mechanistically, cytoplasmic STAT4 could interact with E3 ligase CHIP and block RIG-I and CHIP association, preventing CHIP-mediated proteasomal degradation of RIG-I via K48-linked ubiquitination.
p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.
Cabodi et al., Torino, Italy. In Oncotarget, Jan 2016
Indeed, the overexpression of p130Cas impairs ErbB2 ubiquitination by inhibiting the binding of Cbl and CHIP E3 ligases to ErbB2.
Novel endogenous angiogenesis inhibitors and their therapeutic potential.
Ge et al., Singapore, Singapore. In Acta Pharmacol Sin, Oct 2015
In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA.
[Effects of high-flux hemodialysis on FGF-23 and micro-inflammatory state in end-stage renal diseases patients].
Wang et al., In Zhonghua Yi Xue Za Zhi, Aug 2015
05) and CHIP, IL-6l, PTH and FGF-23 significantly decreased in HFHD group (P <0.
A CHIPotle in physiology and disease.
Ghosh et al., Calcutta, India. In Int J Biochem Cell Biol, 2015
The carboxy-terminus of Hsc70 interacting protein (CHIP) is known to function as a chaperone associated E3 ligase for several proteins and regulates a variety of physiological processes.
CHIP: a co-chaperone for degradation by the proteasome.
Edkins, Grahamstown, South Africa. In Subcell Biochem, 2014
Similar to folding complexes, the ability of chaperones to mediate protein degradation is regulated by co-chaperones, such as the C terminal Hsp70 binding protein (CHIP).
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
Lieberman et al., In Annu Rev Pharmacol Toxicol, 2014
Hsp90 and Hsp70 have opposing effects on client protein stability in protein quality control; Hsp90 stabilizes the clients and inhibits their ubiquitination, whereas Hsp70 promotes ubiquitination dependent on CHIP (C terminus of Hsc70-interacting protein) and proteasomal degradation.
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Cardona-Gómez et al., Medellín, Colombia. In Front Cell Neurosci, 2014
BACE1 targeting increased Hsc70 levels in the membrane and cytoplasm fractions and downregulated Hsp90 and CHIP in the nucleus in the hippocampi of 3xTg-AD mice.
Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo.
Horrevoets et al., Amsterdam, Netherlands. In Plos One, 2014
Chromosome immunoprecipitation (CHIP) confirms binding of KLF2 to the AQP1 promoter.
The E3 ligase CHIP: insights into its structure and regulation.
Ghosh et al., Calcutta, India. In Biomed Res Int, 2013
The carboxy-terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase containing three tandem repeats of tetratricopeptide (TPR) motifs and a C-terminal U-box domain separated by a charged coiled-coil region.
miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression.
Chang et al., Beijing, China. In J Bone Miner Res, 2012
miR-764-5p positively regulates osteoblast differentiation from osteoblast progenitor cells by repressing the translation of CHIP protein
The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.
Ghosh et al., Calcutta, India. In J Biol Chem, 2012
Data show that CHIP interacts with PTEN and promotes its proteasomal degradation.
Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.
Strous et al., Utrecht, Netherlands. In J Biol Chem, 2012
Data show that growth hormone receptor (GHR) endocytosis requires both ubiquitin-conjugating enzyme Ubc13 and the ubiquitin ligase COOH terminus of Hsp70 interacting protein (CHIP).
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Abe et al., Rochester, United States. In Circ Res, 2012
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments.
Stanwood et al., Nashville, United States. In Plos One, 2011
data indicate a clear subset of behaviors that are altered at baseline in CHIP deficient animals including wire hang, inverted screen, wire maneuver, and open field tasks
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
Yanagisawa et al., Tsukuba, Japan. In Nat Cell Biol, 2009
CHIP inhibits anchorage-independent cell growth and metastatic potential by degrading oncogenic proteins including SRC-3.
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Rajalingam et al., Frankfurt am Main, Germany. In Nat Cell Biol, 2008
XIAP promotes binding of CHIP (carboxy terminal Hsc70-interacting protein), a chaperone-associated ubiquitin ligase, to the C-RAF-Hsp90 complex in vivo.
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.
Cyr et al., Chapel Hill, United States. In Cell, 2006
We identified an ER membrane-associated ubiquitin ligase complex containing the E3 RMA1, the E2 Ubc6e, and Derlin-1 that cooperates with the cytosolic Hsc70/CHIP E3 complex to triage CFTR and CFTR Delta F508.
Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.
Shastri et al., Berkeley, United States. In Immunity, 2006
Generation of pMHC I was also inhibited by knockdown of the cochaperone CHIP that interacts with heat shock proteins, ubiquitinates their clients, and delivers them to the proteasome.
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