Genetic association between human chitinases and lung function in COPD.
Vancouver, Canada. In Hum Genet, 2012
study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
San Francisco, United States. In Nature, 2007
Tissue infiltration was unaffected by the absence of Toll-like-receptor-mediated lipopolysaccharide recognition but did not occur if the injected chitin was pre-treated with the IL-4- and IL-13-inducible mammalian chitinase, AMCase, or if the chitin was injected into mice that overexpressed AMCase.