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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Chitinase, acidic

Chia, acidic mammalian chitinase, AMCase
Top mentioned proteins: Chitinase, ACID, HAD, CAN, fibrillin-1
Papers on Chia
Non-target effects of repeated chlorothalonil application on soil nitrogen cycling: The key functional gene study.
New
Li et al., Nanjing, China. In Sci Total Environ, Mar 2016
Real time PCR (RT-PCR) revealed that repeated CTN applications had negative effects on the chiA and aprA gene abundances.
Processivity, Substrate Positioning, and Binding: The Role of Polar Residues in a Family 18 Glycoside Hydrolase.
New
Sørlie et al., Portugal. In Biochemistry, Jan 2016
Exchanging Thr(276) with Ala in substrate binding subsite -2 in the processive ChiA of Serratia marcescens results in a decrease in both the enthalpy (2.6 and 3.8 kcal/mol) and free energy (0.5 and 2.2 kcal/mol) for the binding to the substrate (GlcNAc)6 and the inhibitor allosamidin, respectively, compared to that of the wild type.
Slow Off-rates and Strong Product Binding Are Required for Processivity and Efficient Degradation of Recalcitrant Chitin by Family 18 Chitinases.
New
Väljamäe et al., Tartu, Estonia. In J Biol Chem, Dec 2015
The method was applied to the study of the processive chitinase ChiA from Serratia marcescens.
A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study.
New
van de Sande et al., Rotterdam, Netherlands. In Plos Negl Trop Dis, Sep 2015
Polymorphisms in the genes encoding for the chitin-degrading enzymes chitotriosidase and AMCase were described, resulting in altered chitinase activity.
Beneficial health effects of Chios Gum Mastic and peroxisome proliferator-activated receptors: indications of common mechanisms.
Review
Perrea et al., Athens, Greece. In J Med Food, 2015
For thousands of years, Chios Gum Mastic (CGM), the resin produced by the trunk of Pistachia lentiscus var Chia, has been used for culinary and medicinal purposes and several therapeutic properties have been attributed to it.
Chia (Salvia hispanica): A Review of Native Mexican Seed and its Nutritional and Functional Properties.
Review
Tecante et al., Mexico. In Adv Food Nutr Res, 2014
In this chapter, a review is made on various aspects of chia seed in order to provide an overall, yet comprehensive view, about this important commodity with the aim of updating the current state of knowledge on its composition, possible nutraceutical properties, and potential benefits for human health.
The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma.
Liu et al., Taiwan. In Int J Mol Sci, 2014
It has been shown that an elicited expression of acidic mammalian chitinase (AMCase) may be involved in the pathogenesis of asthma.
Neutrophils as a Source of Chitinases and Chitinase-Like Proteins in Type 2 Diabetes.
Piwowar et al., Wrocław, Poland. In Plos One, 2014
We aimed to determine the levels of neutrophil-derived chitotriosidase (CHIT1), acidic mammalian chitinase (AMCase) and chitinase 3-like protein 1 (YKL-40) in patients with type 2 diabetes (T2D) and verify their association with metabolic and clinical conditions of these patients.
Characterization of Thermotolerant Chitinases Encoded by a Brevibacillus laterosporus Strain Isolated from a Suburban Wetland.
Miao et al., Wuhan, China. In Genes (basel), 2014
Taking thermostability into account, the chitinases (ChiA and ChiC) of a B. laterosporus strain were studied further.
Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease.
Review
Mizoguchi et al., Boston, United States. In World J Gastroenterol, 2014
Recent studies strongly suggested that chitinase 3-like 1 (CHI3L1, also known as YKL-40) and acidic mammalian chitinase, the two major members of family 18 chitinases, play a pivotal role in the pathogenesis of inflammatory bowel disease (IBD), bronchial asthma and several other inflammatory disorders.
The shape of things to come.
Impact
Zipursky et al., Los Angeles, United States. In Cell, 2014
Chia et al.
Genetic association between human chitinases and lung function in COPD.
GeneRIF
Sandford et al., Vancouver, Canada. In Hum Genet, 2012
study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated
Acidic mammalian chitinase is not a critical target for allergic airway disease.
GeneRIF
Williams et al., Cambridge, United States. In Am J Respir Cell Mol Biol, 2012
Although exposure to allergen stimulates the expression of AMCase and increased chitinolytic activity in murine airways, the overexpression or inhibition of AMCase exerts only a subtle impact on AAD.
[Study on the discovery of novel chitinase inhibitors based on natural products].
Review
Hirose, Tokyo, Japan. In Yakugaku Zasshi, 2011
Paradoxically, while chitin does not exist in mammals, human chitinase family members, such as acidic mammalian chitinase, have recently been described, and offer significant potential for the treatment of asthma and other related diseases in humans.
The effects of an insertion in the 5'UTR of the AMCase on gene expression and pulmonary functions.
GeneRIF
Kalayci et al., Ankara, Turkey. In Respir Med, 2011
A ten base pair insertion in the second exon in the 5'UTR region of the AMCase gene may modify the gene expression and thus may affect the severity of asthma.
A possible role of chitin in the pathogenesis of asthma and allergy.
Review
Sigsgaard et al., Århus, Denmark. In Ann Agric Environ Med, 2011
The amount of acidic mammalian chitinase correlates with asthma, and the enzyme has been shown to induce chemokine secretion in murine lungs.
Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps.
GeneRIF
Jin et al., Shenyang, China. In J Otolaryngol Head Neck Surg, 2011
AMCase and eotaxin-3 may be important mediators in the pathogenesis of nasal polyps. The increased AMCase and eotaxin-3 might lead to nasal polyp formation and growth.
Chitinolytic activity in nasal polyps.
GeneRIF
Yang et al., Pusan, South Korea. In Am J Rhinol Allergy, 2011
increased chitinolytic activity in nasal polyps
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
Impact
Locksley et al., San Francisco, United States. In Nature, 2007
Tissue infiltration was unaffected by the absence of Toll-like-receptor-mediated lipopolysaccharide recognition but did not occur if the injected chitin was pre-treated with the IL-4- and IL-13-inducible mammalian chitinase, AMCase, or if the chitin was injected into mice that overexpressed AMCase.
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
Impact
GeneRIF
Elias et al., New Haven, United States. In Science, 2004
findings show that acidic mammalian chitinase is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13)-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model
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