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Forkhead box N3

CHES1, FOXN3, checkpoint suppressor 1
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HTLF, SET, Foxn1, Foxn4
Papers on CHES1
Polygenic associations of neurodevelopmental genes in suicide attempt.
Wasserman et al., Stockholm, Sweden. In Mol Psychiatry, Jan 2016
Among the 590 SA polygenes implicated here, there were several developmentally important functions (cell adhesion/migration, small GTPase and receptor tyrosine kinase signaling), and 16 of the SA polygenes have previously been studied in SB (BDNF, CDH10, CDH12, CDH13, CDH9, CREB1, DLK1, DLK2, EFEMP1, FOXN3, IL2, LSAMP, NCAM1, nerve growth factor (NGF), NTRK2 and TBC1D1).
A Systematic Approach to Defining the microRNA Landscape in Metastasis.
Allgayer et al., Mannheim, Germany. In Cancer Res, Sep 2015
These targets include SIAH1, SETD2, ZEB2, and especially FOXN3, which we demonstrated for the first time as a direct transcriptional suppressor of N-cadherin.
Transcriptomic profiling of Forkhead box transcription factors in adult glioblastoma multiforme.
Madhusudan et al., Nottingham, United Kingdom. In Cancer Genomics Proteomics, May 2015
RESULTS: Low FOXA2 mRNA, low FOXN2 mRNA, low FOXN3 mRNA and high FOXG1 mRNA were associated with poor survival in the test and TCGA validation cohorts.
Deregulated FOX genes in Hodgkin lymphoma.
MacLeod et al., Braunschweig, Germany. In Genes Chromosomes Cancer, 2014
Here, we screened six Hodgkin lymphoma (HL) cell lines for FOX gene activity by comparative microarray profiling, revealing overexpression of FOXC1 and FOXD1, and reduced transcription of FOXN3, FOXO1, and FOXP1.
Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain.
Waldmann et al., Marburg an der Lahn, Germany. In J Clin Endocrinol Metab, 2014
Patients with mutations leading to loss of interaction (LOI) with the checkpoint kinase 1 (CHES1) interacting domain codons (428-610) compared with patients with mutations resulting in LOI with other domains (eg, JunD, Smad3) had significantly higher rates of functioning pNENs (70% vs 34%), malignant pNENs (59% vs 16%), and aggressive pNENs (37% vs 9%), respectively.
Submicroscopic genomic rearrangements change gene expression in T-cell large granular lymphocyte leukemia.
Przybylski et al., Poznań, Poland. In Eur J Haematol, 2014
Nineteen genes, among them FOXN3, RIN3, AKT1, PPP2R5C, were overexpressed as a result of an amplification in 14q in one T-LGL patient.
Genome-wide association study identifies new disease loci for isolated clubfoot.
Gurnett et al., Saint Louis, United States. In J Med Genet, 2014
Additional suggestive SNPs were identified near FOXN3, SORCS1 and MMP7/TMEM123 that also confirmed on replication.
CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.
Ferbeyre et al., Montréal, Canada. In Mol Biol Cell, 2014
The expression of the forkhead transcription factor checkpoint suppressor 1 (CHES1), also known as FOXN3, is reduced in many types of cancers.
Identification of novel genomic aberrations in AML-M5 in a level of array CGH.
Li et al., Shenyang, China. In Plos One, 2013
As a tumor suppressor gene, FOXN3, was singled out from the small recurrent CNA of 14q32, however, it is proved that deletion of FOXN3 is a common marker of myeloid leukemia rather than a specific marker for AML-M5 subtype.
Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network.
Xu et al., Shenyang, China. In J Ovarian Res, 2013
Other TFs, such as BIN1, FOXN3, FOXK1, FOXP2, and ESRRG with high degrees may be inhibited in ovarian cancer.
Fine mapping study reveals novel candidate genes for carotid intima-media thickness in Dominican Republican families.
Sacco et al., Miami, United States. In Circ Cardiovasc Genet, 2012
Among the families, evidence for association (P<0.001) was found in multiple genes (ANLN, AOAH, FOXN3, CCDC88C, PRiMA1, and an intergenic SNP rs1667498), with the strongest association at PRiMA1 (P=0.00007,
MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.
Ren et al., Shanghai, China. In Plos One, 2011
Notably, we identified checkpoint suppressor 1 (Ches1) as the dominant direct target for miRNA-574-5p to confer the TLR9 signaling enhanced tumor progression.
Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract.
Cheng et al., Anyang, China. In Head Neck, 2011
Six genes were confirmed over 2-fold of changes, including Ches1.
Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
Venkatachalam et al., Knoxville, United States. In Biochem Biophys Res Commun, 2010
the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects.
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Jarzab et al., Katowice, Poland. In Eur Arch Otorhinolaryngol, 2009
Four genes previously not examined in that respect in laryngeal carcinoma, occurred to be good markers of the neoplasm. They are: metal-proteinase ADAM12, cyclin-dependent kinase 2-CDK2, kinesin 14-KIF14, suppressor 1 of checkpoint-CHES1.
A child with deletion (14)(q24.3q32.13) and auditory neuropathy.
Cox et al., Edmonton, Canada. In Am J Med Genet A, 2008
FOXN3 might contribute to the observed phenotype.
Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
Shibata et al., Tokyo, Japan. In Gastroenterology, 2007
Two novel homozygously deleted genes in hepatocellular carcinomas are caspase 3 and CHES1.
Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response.
Bale et al., New Haven, United States. In Cancer Res, 2006
Meninis involved in the activation of S-phase arrest in multple endocrein neoplasia by interacting with CHES1.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
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