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CKLF-like MARVEL transmembrane domain containing 8

chemokine-like factor superfamily 8, CKLFSF8, CMTM8
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EGFR, V1a, HAD, CAN, PrP
Papers on chemokine-like factor superfamily 8
Functional characterization of the tumor suppressor CMTM8 and its association with prognosis in bladder cancer.
Na et al., Beijing, China. In Tumour Biol, Dec 2015
UNASSIGNED: Previous research revealed that CMTM8 acts as a tumor suppressor gene in variety cancers.
CMTM8 is Frequently Downregulated in Multiple Solid Tumors.
Wang et al., Beijing, China. In Appl Immunohistochem Mol Morphol, Dec 2015
UNASSIGNED: Previous studies have demonstrated that overexpression of CMTM8 inhibits cell growth and induces apoptosis in multiple types of cancer cells, whereas the downregulation of CMTM8 induces the epithelial-to-mesenchymal (EMT)-like phenotype in hepatocyte carcinoma cells, implying its important roles in tumorigenesis and tumor metastasis.
CMTM8 inhibits the carcinogenesis and progression of bladder cancer.
Xu et al., Beijing, China. In Oncol Rep, Oct 2015
Chemokine‑like factor (CKLF)‑like MARVEL transmembrane domain containing 8 (CMTM8) is downregulated in several types of cancers and is associated with tumor progression.
Genome-wide association discoveries of alcohol dependence.
Luo et al., New Haven, United States. In Am J Addict, 2014
The associations with the variants within NRD1, GPD1L-CMTM8 or MAP3K9-PCNX were suggestive (5 × 10(-8)  < p < 10(-5) ) in some samples, and nominally replicable in other samples.
Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma.
Hulsebos et al., Amsterdam, Netherlands. In Plos One, 2013
We identified CMTM8 as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene in osteosarcoma.
[Expressions of CMTM8 and E-cadherin in primary and metastatic clear cell renal cell carcinoma].
Wang et al., Beijing, China. In Beijing Da Xue Xue Bao, 2013
OBJECTIVE: To investigate the expression and clinical pathological significance of CMTM8 and E-cadherin in primary and metastatic clear-cell renal cell carcinoma.
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.
Wang et al., Beijing, China. In J Biol Chem, 2012
Down-regulation of CMTM8 also promoted an epithelial mesenchymal transition-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation.
Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.
Reif et al., Würzburg, Germany. In Neuropsychopharmacology, 2011
To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients.
[Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
Chen et al., Beijing, China. In Yao Xue Xue Bao, 2010
Testosterone did not influence the expression of CKLF1, CMTM3 and CMTM5, the CMTM6, CMTM7 and CMTM8 of CMTM family were not detected in testis tissue.
[Effects of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of HL-60 cells].
Dong et al., Zhengzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007
This study was aimed to investigate the effect of chemokine-like factor superfamily 8 (CKLFSF8) on proliferation and expression of epidermal growth factor receptor (EGFR) of HL-60 cells.
CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway.
Ma et al., Beijing, China. In J Cell Physiol, 2007
These data implicate CMTM8 as a negative regulator of epidermal growth factor (EGF)-induced signaling.
An alternative splice form of CMTM8 induces apoptosis.
Wang et al., Beijing, China. In Int J Biochem Cell Biol, 2006
The cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8, is reported.
[Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells].
Du et al., Zhengzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2006
Cell proliferation and expression of EGFR of tumor cells can be inhibited by transfection of CKLFSF8.
Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8.
Ma et al., Beijing, China. In Febs Lett, 2005
These results identify CKLFSF8 as a novel regulator of EGF-induced signaling and indicate that the association of EGFR with four transmembrane proteins is critical for EGFR desensitization.
Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.
Ma et al., Beijing, China. In Genomics, 2003
Bioinformatics based on CKLF2 cDNA and protein sequences in combination with experimental validation identified CKLFSF1-8 gene clusters, between the SCY and the TM4SF gene families. The 8 family members were cloned and characterized.
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