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Chromodomain helicase DNA binding protein 3

CHD3
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, Chordin, Mi-2beta, V1a
Papers on CHD3
Quasiclassical Trajectory Study on the Role of CH-Stretching Vibrational Excitation in the F((2)P) + CHD3(v1=0,1) Reactions.
New
Espinosa-Garcia, Badajoz, Spain. In J Phys Chem A, Feb 2016
To analyze the role of CH-stretching vibrational excitation on the reactivity and dynamics of the F((2)P) + CHD3(v1=0,1) reactions, quasiclassical trajectory calculations using a full-dimensional analytical potential energy surface at different collision energies were performed.
Rotational Mode Specificity in Cl + CH4(v3 = 1, jNl ): Role of Reactant's Vibrational Angular Momentum.
New
Liu et al., In J Phys Chem A, Feb 2016
This finding echoes the previous conclusion in the analogous Cl + CHD3(v1 = 1, NK ) reaction.
Epigenetic Regulation of Vegetative Phase Change in Arabidopsis.
New
Poethig et al., Philadelphia, United States. In Plant Cell, Jan 2016
The CHD3 chromatin remodeler, PICKLE (PKL), promotes the addition of H3K27me3 to MIR156A/MIR156C, but is not responsible for the temporal increase in this chromatin mark.
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
New
Impact
Palomero et al., New York City, United States. In Nat Genet, Dec 2015
Mutation analysis identified a broad spectrum of somatic mutations in key genes involved in epigenetic regulation (TET2, CREBBP, KMT2D (MLL2), KMT2C (MLL3), BRD9, SMARCA4 and CHD3) and signaling, including MAPK1, BRAF, CARD11 and PRKG1 mutations driving increased MAPK, NF-κB and NFAT activity upon T cell receptor stimulation.
Structure and function insights into the NuRD chromatin remodeling complex.
Review
New
Klaholz et al., Illkirch-Graffenstaden, France. In Cell Mol Life Sci, Jul 2015
NuRD is a 1 MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Review
New
Vermeulen et al., Nijmegen, Netherlands. In Febs J, May 2015
STRUCTURED DIGITAL ABSTRACT: MBD3 physically interacts with ZNF512B, HDAC1, ZMYND8, GATAD2B, SALL4, GATAD2A, ZNF592, MTA3, ZNF687, CDK2AP1, CHD3, ZNF532, HDAC2, MTA2, CHD4, MTA1, KPNA2, CHD5, RBBP4 and RBBP7 by pull down (View interaction) CDK2AP1 physically interacts with MBD3, MTA3, HDAC2, GATAD2A, CHD4, CDK2AP1, MTA2, HDAC1, MTA1, CHD3, GATAD2B, MBD2, RBBP4 and RBBP7 by pull down (View interaction) MBD3 physically interacts with MTA2, MTA3, RBBP4, RBBP7, HDAC2, HDAC1, CHD4, CHD3 and MTA1 by cross-linking study (View interaction).
CHR729 Is a CHD3 Protein That Controls Seedling Development in Rice.
Han et al., Beijing, China. In Plos One, 2014
In this study, a rice CHD3 protein, CHR729, was identified.
Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors.
Lusser et al., Innsbruck, Austria. In Front Behav Neurosci, 2014
Moreover, a select reduction in CHD3 expression was observed in the ventral hippocampus (vHC) following successful rescue of fear extinction in S1 mice.
CHD chromatin remodelling enzymes and the DNA damage response.
Review
Goodarzi et al., Calgary, Canada. In Mutat Res, 2013
We will first touch upon all four major chromatin remodelling enzyme families and then focus chiefly on the nine members of the Chromodomain, Helicase, DNA-binding (CHD) family, particularly CHD3, CHD4, CHD5 and CHD6.
Theoretical Study of the Validity of the Polanyi Rules for the Late-Barrier Cl + CHD3 Reaction.
Bowman et al., Dalian, China. In J Phys Chem Lett, 2013
The Polanyi rules, which state that vibrational energy is more efficient in promoting a late-barrier reaction than translational energy, were questioned recently by an experimental unexpected finding that the CH stretch excitation is no more effective in promoting the late-barrier Cl + CHD3 reaction than the translational energy.
The CHD3 remodeler PICKLE associates with genes enriched for trimethylation of histone H3 lysine 27.
GeneRIF
Ogas et al., West Lafayette, United States. In Plant Physiol, 2012
PKL plays a role in chromatin homeostasis.
The CKH2/PKL chromatin remodeling factor negatively regulates cytokinin responses in Arabidopsis calli.
GeneRIF
Kakimoto et al., Toyonaka, Japan. In Plant Cell Physiol, 2011
CKH1/EER4/AtTAF12b and CKH2/PKL may act together on cytokinin-regulated genes.
The CHD3 chromatin remodeler PICKLE and polycomb group proteins antagonistically regulate meristem activity in the Arabidopsis root.
GeneRIF
Köhler et al., Zürich, Switzerland. In Plant Cell, 2011
Loss of PKL function impairs root growth in Arabidopsis.
Steric control of the reaction of CH stretch-excited CHD3 with chlorine atom.
Impact
Liu et al., Taipei, Taiwan. In Science, 2011
Exciting the CH-stretching mode of CHD(3) (where D is deuterium) is known to promote the C-H bond's reactivity toward chlorine (Cl) atom.
Epigenetic silencing of endogenous repetitive sequences by MORPHEUS' MOLECULE1 in Arabidopsis thaliana.
Review
Habu, Tsukuba, Japan. In Epigenetics, 2010
Although MOM1 is evolutionarily related to chromodomain helicase DNA binding protein3 (CHD3), a family of chromatin remodeling proteins involved in repression of gene expression, MOM1 does not carry the functional ATPase/helicase domain essential for chromatin remodeling activity, and therefore, its mode of action is unknown.
CHD3 proteins and polycomb group proteins antagonistically determine cell identity in Arabidopsis.
GeneRIF
Köhler et al., Zürich, Switzerland. In Plos Genet, 2009
PKL and PKR2 are required for the expression of many genes that are repressed by PcG proteins.
CH stretching excitation in the early barrier F + CHD3 reaction inhibits CH bond cleavage.
Impact
Liu et al., Taipei, Taiwan. In Science, 2009
We report here an in-depth experimental study of the reactivity effects exerted by reactant C-H stretching excitation in a prototypical early-barrier reaction, F + CHD3.
UV radiation regulates Mi-2 through protein translation and stability.
GeneRIF
Archer et al., United States. In J Biol Chem, 2009
UV radiation regulates Mi-2 through protein translation and stability
Bond-selective control of a heterogeneously catalyzed reaction.
Impact
Utz et al., Medford, United States. In Science, 2008
State-resolved gas-surface scattering measurements show that the nu1 C-H stretch vibration in trideuteromethane (CHD3) selectively activates C-H bond cleavage on a Ni(111) surface.
Do vibrational excitations of CHD3 preferentially promote reactivity toward the chlorine atom?
Impact
Liu et al., Taipei, Taiwan. In Science, 2007
By precise tuning of translational energies, we measured the relative efficiencies of vibration and translation in promoting the gas-phase reaction of CHD3 with the Cl atom to form HCl and CD3.
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