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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CHD1 Chd1p

CHD1, Hrp1, Chd1p
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, POLYMERASE, ATPase, Chordin
Papers on CHD1
A Phase II Study of AT-101 to Overcome Bcl-2-Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer.
New
DiPaola et al., New Brunswick, United States. In Clin Genitourin Cancer, Feb 2016
To assess for an association between chromodomain helicase DNA binding protein 1 (CHD1) and drug sensitivity, fluorescence in situ hybridization with confocal microscopy was assessed in a subgroup of patients.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
New
Sch├╝le et al., Freiburg, Germany. In Nat Struct Mol Biol, Feb 2016
We identified CHD1 as a KDM1A K114me2 reader and characterized the KDM1A K114me2-CHD1 recognition mode by solving the cocrystal structure.
Prostate cancer.
Review
New
Impact
de Bono et al., London, United Kingdom. In Lancet, Feb 2016
Classification of prostate cancer into distinct molecular subtypes, including mutually exclusive ETS-gene-fusion-positive and SPINK1-overexpressing, CHD1-loss cancers, could allow stratification of patients for different management strategies.
Haemosporidian infections in the Tengmalm's Owl (Aegolius funereus) and potential insect vectors of their transmission.
New
Munclinger et al., Praha, Czech Republic. In Parasitol Res, Jan 2016
Sex of owl nestlings was scored using molecular sexing based on fragment analysis of PCR-amplified CHD1 introns.
An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster.
New
Armstrong et al., Claremont, United States. In G3 (bethesda), Dec 2015
UNASSIGNED: The conserved chromatin remodeling and assembly factor CHD1 (chromodomains, helicase, DNA-binding domain) is present at active genes where it participates in histone turnover and recycling during transcription.
(1)H, (13)C and (15)N resonance assignments of a C-terminal domain of human CHD1.
New
Ryan et al., Sydney, Australia. In Biomol Nmr Assign, Sep 2015
Chromodomain helicase DNA-binding protein 1 (CHD1) is one such remodelling protein that has specialised nucleosome organising abilities and is conserved across eukaryotes.
Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment.
Review
New
Tewari et al., New York City, United States. In Urol Oncol, Jun 2015
New recurrent alterations have been identified in PCa (e.g., TMPRSS2-ERG translocation, SPOP and CHD1 mutations, and chromoplexy), and many previous ones in well-established pathways have been validated (e.g., androgen receptor overexpression and mutations; PTEN, RB1, and TP53 loss/mutations).
Molecular foundations for personalized therapy in prostate cancer.
Review
Cheng et al., Indianapolis, United States. In Curr Drug Targets, 2014
Lastly, we briefly discuss emerging genetic subtypes defined by either SPINK1 overexpression, CHD1 inactivation, or SPOP mutations.
Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors.
Lusser et al., Innsbruck, Austria. In Front Behav Neurosci, 2014
Using this model along with genetically related but fear extinction-competent 129S6/SvEv (S6) mice as controls, we found that impaired fear extinction in S1 was associated with enhanced ventral hippocampal expression of CHD1 and reduced expression of CHD5 that was normalized following successful rescue of impaired fear extinction.
Organoid cultures derived from patients with advanced prostate cancer.
Impact
Chen et al., New York City, United States. In Cell, 2014
The first seven fully characterized organoid lines recapitulate the molecular diversity of prostate cancer subtypes, including TMPRSS2-ERG fusion, SPOP mutation, SPINK1 overexpression, and CHD1 loss.
Balancing chromatin remodeling and histone modifications in transcription.
Review
Pillus et al., San Diego, United States. In Trends Genet, 2013
Here, we highlight recent advances in the interactions between histone modifications and the imitation-switch (ISWI) and chromodomain helicase DNA-binding protein 1 (CHD1) chromatin remodelers from studies in budding yeast, fission yeast, flies, and mammalian cells, with a focus on yeast.
Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.
GeneRIF
Pollack et al., Stanford, United States. In Oncogene, 2012
findings suggest that CHD1 deletion may underlie cell invasiveness in a subset of prostate cancers, and indicate a possible novel role of altered chromatin remodeling in prostate tumorigenesis
Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer.
GeneRIF
Xu et al., Winston-Salem, United States. In Oncogene, 2012
findings collectively suggest that distinct CHD1-associated alterations of genomic structure evolve during and are required for the development of prostate cancer
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.
GeneRIF
Workman et al., Kansas City, United States. In Nat Struct Mol Biol, 2012
Deletion of ISW1 and CHD1 causes widespread intragenic transcription.
The mutational landscape of lethal castration-resistant prostate cancer.
Impact
Tomlins et al., Ann Arbor, United States. In Nature, 2012
Integrating exome copy number analysis identified disruptions of CHD1 that define a subtype of ETS gene family fusion-negative prostate cancer.
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.
GeneRIF
Shilatifard et al., Kansas City, United States. In Genes Dev, 2012
this study provides evidence that only small levels of H2BK123ub are necessary for full levels of H3K4 and H3K79 trimethylation in vivo and points to a possible role for Chd1 in positively regulating gene expression through promoting nucleosome reassembly coupled with H2B monoubiquitination.
The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study.
GeneRIF
Chen et al., Shanghai, China. In Epigenetics, 2011
CHD1, was the most "dietary sensitive" genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined.
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo.
Impact
GeneRIF
Fyodorov et al., United States. In Science, 2007
findings establish CHD1 as a major factor in replacement histone metabolism in the nucleus and reveal a critical role for CHD1 in the earliest developmental instances of genome-scale, replication-independent nucleosome assembly.
The ins and outs of ATP-dependent chromatin remodeling in budding yeast: biophysical and proteomic perspectives.
Review
Logie et al., Nijmegen, Netherlands. In Biochim Biophys Acta, 2007
We focus on the budding yeast versions of SWI/SNF, RSC, DDM1, ISWI, CHD1, INO80 and SWR1.
Double chromodomains cooperate to recognize the methylated histone H3 tail.
Impact
GeneRIF
Khorasanizadeh et al., Charlottesville, United States. In Nature, 2006
the structure of the tandem arrangement of the human CHD1 chromodomains, and its interactions with histone tails
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