London, United Kingdom. In Lancet, Feb 2016
Classification of prostate cancer into distinct molecular subtypes, including mutually exclusive ETS-gene-fusion-positive and SPINK1-overexpressing, CHD1-loss cancers, could allow stratification of patients for different management strategies.
Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment.
New York City, United States. In Urol Oncol, Jun 2015
New recurrent alterations have been identified in PCa (e.g., TMPRSS2-ERG translocation, SPOP and CHD1 mutations, and chromoplexy), and many previous ones in well-established pathways have been validated (e.g., androgen receptor overexpression and mutations; PTEN, RB1, and TP53 loss/mutations).
Balancing chromatin remodeling and histone modifications in transcription.
San Diego, United States. In Trends Genet, 2013
Here, we highlight recent advances in the interactions between histone modifications and the imitation-switch (ISWI) and chromodomain helicase DNA-binding protein 1 (CHD1) chromatin remodelers from studies in budding yeast, fission yeast, flies, and mammalian cells, with a focus on yeast.
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.
Kansas City, United States. In Genes Dev, 2012
this study provides evidence that only small levels of H2BK123ub are necessary for full levels of H3K4 and H3K79 trimethylation in vivo and points to a possible role for Chd1 in positively regulating gene expression through promoting nucleosome reassembly coupled with H2B monoubiquitination.