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Regulator of chromosome condensation

CHC1L, chromosome condensation 1-like, RCBTB2
This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RAN, pRb, RCC1, FBD, HAD
Papers on CHC1L
Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.
Rudenko et al., Nottingham, United Kingdom. In J Biol Chem, Dec 2015
In addition, we identify two novel ISWI partners, regulator of chromosome condensation 1-like protein (RCCP) and phenylalanine/tyrosine-rich protein (FYRP), both containing protein motifs typically found on chromatin proteins.
Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene.
Shu et al., Glasgow, United Kingdom. In Invest Ophthalmol Vis Sci, Oct 2015
CONCLUSIONS: The regulator of chromosome condensation 1-like domain of RPGR was conserved in vertebrates and invertebrates, but RPGR(ORF15) was unique to vertebrates, consistent with a proposed role in the ciliary-based transport of cargoes such as rhodopsin, which is ∼10 times more abundant in vertebrate than invertebrate photoreceptors.
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.
CamCaP Study Group et al., Cambridge, United Kingdom. In Ebiomedicine, Sep 2015
We confirm alterations in six genes previously associated with prostate cancer (MAP3K7, MELK, RCBTB2, ELAC2, TPD52, ZBTB4), and also identify 94 genes not previously linked to prostate cancer progression that would not have been detected using either transcript or copy number data alone.
Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms.
Wen et al., Toronto, Canada. In Plos One, 2014
Chromosome Condensation 1-like (CHC1L) is located at 13q14, and found within the smallest common region of loss of heterozygosity in prostate cancer.
Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma.
Libbrecht et al., In Virchows Arch, 2014
In the atypical spindle cell lipomas, MLPA revealed deletions in the two nearest flanking genes of RB1 (ITM2B and RCBTB2) and in multiple important exons of RB1.
Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma.
San Miguel et al., Salamanca, Spain. In Br J Haematol, 2008
RAN, ZHX2 and RCBTB2 (CHC1L) expression was evaluated by quantitative real time reverse transcription polymerase chain reaction in plasma cells from 85 monoclonal gammopathies: 58 symptomatic multiple myeloma (MM) (52 untreated, six relapsed), eight smouldering MM, five monoclonal gammopathy of undetermined significance, four plasma cell leukaemias and 10 myeloid cell lines.
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.
Czerniak et al., Houston, United States. In Proc Natl Acad Sci U S A, 2007
We subsequently concentrated our efforts on the two neighbor genes flanking RB1, namely ITM2B and CHC1L, as well as P2RY5, which is located inside RB1.
Multiple myeloma.
Richardson et al., Nantes, France. In Hematology Am Soc Hematol Educ Program, 2003
In addition, abnormal expression of only three genes (RAN, ZHX-2, CHC1L) is associated with rapid relapses.
Extensive analysis of the 13q14 region in human prostate tumors: DNA analysis and quantitative expression of genes lying in the interval of deletion.
Cussenot et al., Fontaine, France. In Prostate, 2003
Only four genes (ITM2B, CHC1L, KIAA0970, and LOC51131), located in the region most frequently deleted in prostate carcinoma, showed a significant difference in expression between normal and neoplastic prostate tissues.
A culture device demonstrates that hydrostatic pressure increases mRNA of RGS5 in neuroblastoma and CHC1-L in lymphocytic cells.
Mizuno et al., Tokyo, Japan. In Cells Tissues Organs, 2002
Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure.
CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer.
Cussenot et al., France. In Int J Cancer, 2002
decreased expression in prostate cancer associated with the difference in frequency of variant isoforms between normal and neoplastic prostate tissues places it in a pivotal role or possibly adjacent to a gene with that role in prostate cancer evolution
cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor.
Moisan et al., Nantes, France. In Genomics, 1998
This gene, designated CHC1L (for chromosome condensation 1-like), is composed of 14 exons spanning 30 kb of genomic DNA and encodes a ubiquitously expressed 3-kb mRNA.
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