Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene.
Glasgow, United Kingdom. In Invest Ophthalmol Vis Sci, Oct 2015
CONCLUSIONS: The regulator of chromosome condensation 1-like domain of RPGR was conserved in vertebrates and invertebrates, but RPGR(ORF15) was unique to vertebrates, consistent with a proposed role in the ciliary-based transport of cargoes such as rhodopsin, which is ∼10 times more abundant in vertebrate than invertebrate photoreceptors.
Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma.
Salamanca, Spain. In Br J Haematol, 2008
RAN, ZHX2 and RCBTB2 (CHC1L) expression was evaluated by quantitative real time reverse transcription polymerase chain reaction in plasma cells from 85 monoclonal gammopathies: 58 symptomatic multiple myeloma (MM) (52 untreated, six relapsed), eight smouldering MM, five monoclonal gammopathy of undetermined significance, four plasma cell leukaemias and 10 myeloid cell lines.
Nantes, France. In Hematology Am Soc Hematol Educ Program, 2003
In addition, abnormal expression of only three genes (RAN, ZHX-2, CHC1L) is associated with rapid relapses.