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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Clathrin, heavy chain

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, POLYMERASE
Papers using CHC antibodies
The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
Rappoport Joshua Z., In PLoS ONE, 2007
... per sample), and M01, clone 4H8; Abnova, Taipei City, Taiwan for IF), anti-clathrin heavy chain (CHC) (RDI Division of Fitzgerald Industries International, Concord, MA ...
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6
Smythe Elizabeth et al., In The Journal of Cell Biology, 2006
... mAb 16B12 (Abcam); anti-rabaptin5, anti–rabex-5, and anti-μ2 (BD Biosciences); mouse anti-clathrin heavy chain and clone CHC 5.9 (MP Biomedicals); Immuno-Pure rabbit anti–mouse IgM ...
A guided tour into subcellular colocalization analysis in light microscopy.
Aguilar Ruben Claudio, In PLoS ONE, 2005
... Additional monoclonal antibodies against α- and β-adaptins, AP180, and CHC (solely used for immunoblotting) were obtained from BD Biosciences (Lexington, KY) ...
G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells.
Keen James, In PLoS ONE, 2004
... 1, mouse anti-Hsp90, mouse anti-flotillin 1, mouse anti-flotillin 2 (BD Biosciences Transduction Laboratories, Lexington, KY); mouse anti-CHC (RDI division of Fitzgerald Industries, Concorde, MA); goat ...
Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1
Trejo JoAnn et al., In The Journal of Cell Biology, 1990
... ), anti–β2 adaptin, anti–early endosomal antigen-1 (EEA1), and anti-CHC monoclonal antibodies were purchased from BD Biosciences.
Papers on CHC
Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein AP2.
Stamme et al., Germany. In Am J Respir Cell Mol Biol, Feb 2016
The central endocytic proteins clathrin heavy chain (CHC) and the clathrin adaptor protein complex AP2 have pivotal alternative roles in cellular homeostasis that are endocytosis-independent.
Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients.
Niu et al., Changchun, China. In J Gastroenterol Hepatol, Feb 2016
We investigated possible correlations of SLC and KLF12 polymorphisms with viral clearance (spontaneous and treatment-induced) and adverse effects in Chinese chronic hepatitis C (CHC) patients.
Could serotonin be a potential marker for hepatocellular carcinoma? A prospective single-center observational study.
Tawfik et al., Al Manşūrah, Egypt. In Eur J Gastroenterol Hepatol, Feb 2016
PATIENTS AND METHODS: Serum serotonin, AFP, and PIVKA-II were measured in 262 patients with chronic hepatitis C (CHC): 82 cirrhotic patients with HCC (group I), 80 cirrhotic patients without HCC (group II), and 100 CHC-infected patients without cirrhosis (group III); in addition, 60 healthy controls were studied (group IV).
Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C.
Lee et al., Kao-hsiung, Taiwan. In J Formos Med Assoc, Jan 2016
BACKGROUND/PURPOSE: Recent studies have shown that serum vitamin D deficiency is a negative predictor of response to peginterferon plus ribavirin therapy for Caucasian patients with chronic hepatitis C (CHC).
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases.
Guarise et al., Abano Terme, Italy. In Int J Biol Macromol, Jan 2016
We used C. histolyticum collagenase (ChC) and bovine testicular hyaluronidase (BTH) as representative models of human MMPs and hyaluronidases, respectively.
Depression and suicide ideation in chronic hepatitis C patients untreated and treated with interferon: prevalence, prevention, and treatment.
Dumitrascu et al., Cluj-Napoca / Kolozsvár, Romania. In Ann Gastroenterol, Oct 2015
Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects.
Impact of epidermal growth factor receptor and transforming growth factor-α on hepatitis C virus-induced hepatocarcinogenesis.
Said et al., Egypt. In Apmis, Oct 2015
Transforming growth factor-α (TGF-α) is an important autocrine growth regulator of hepatocytes that plays a role in development of hepatocellular carcinoma (HCC) among patients with chronic hepatitis C (CHC).
Neutrophil to lymphocyte ratio as a reliable marker to predict insulin resistance and fibrosis stage in chronic hepatitis C virus infection.
Eldars et al., In Acta Gastroenterol Belg, Oct 2015
Chronic hepatitis C (CHC) had biochemical evidence of insulin resistance (IR).
Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting.
Cornberg et al., Hannover, Germany. In Plos One, 2014
BACKGROUND: SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1.
Vitamin D and chronic hepatitis C: effects on success rate and prevention of side effects associated with pegylated interferon-α and ribavirin.
Azhar et al., Asyūţ, Egypt. In Int J Clin Exp Med, 2014
Chronic hepatitis C (CHC) is one of the most common causes of liver diseases worldwide, affecting 3% of the world population and 3 to 4 million people acquire new infection annually.
The cost-effectiveness of novel direct acting antiviral agent therapies for the treatment of chronic hepatitis C.
Bickerstaff, Tallahassee, United States. In Expert Rev Pharmacoecon Outcomes Res, 2014
In the USA, over 3 million individuals are infected with the HCV and 75-85% of them have or will develop chronic hepatitis C (CHC) which can lead to serious consequences such as liver cirrhosis, cancer and death.
Insect Cuticular Hydrocarbons as Dynamic Traits in Sexual Communication.
Ingleby, Brighton, United Kingdom. In Insects, 2014
It is likely that this variability in CHC expression contributes to their important role in sexual signaling and mate choice.
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
Brodsky et al., San Francisco, United States. In J Cell Biol, 2012
Depletion of clathrin heavy chain (CHC)17, but not the CHC22 clathrin isoform, by ribonucleic acid interference (RNAi) induces centrosome amplification and multipolar spindles.
Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.
Howe et al., Charleston, United States. In Embo J, 2012
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.
Marsh et al., Little Rock, United States. In Traffic, 2012
Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number
Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7.
Bergelson et al., Philadelphia, United States. In Mbio, 2011
These results indicate that Echovirus 7 is internalized by clathrin-mediated endocytosis.
Clathrin is required for Scar/Wave-mediated lamellipodium formation.
Gautreau et al., Gif-sur-Yvette, France. In J Cell Sci, 2011
is required for lamellipodium formation
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
Matsuda et al., Tokyo, Japan. In Nat Genet, 2011
Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 × 10(-8)).
Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy.
Filipowicz et al., Basel, Switzerland. In Nat Med, 2009
Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes.
Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin.
Reynolds et al., Richmond, United States. In Nat Biotechnol, 2000
The side chain of the antifungal antibiotic ansatrienin A from Streptomyces collinus contains a cyclohexanecarboxylic acid (CHC)-derived moiety.
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