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Heat shock 10kDa protein 1

Chaperonin 10, EPF, Hsp10, cpn10
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: HSP60, CAN, ACID, HAD, fibrillin-1
Papers on Chaperonin 10
Freezing of body fluids induces metallothionein gene expression in earthworms (Dendrobaena octaedra).
Sørensen et al., Silkeborg, Denmark. In Comp Biochem Physiol C Toxicol Pharmacol, Jan 2016
We hypothesised that both freezing and copper would induce transcription of genes coding for heat shock proteins (hsp10 and hsp70), metallothioneins (mt1 and mt2), and glutathione-S-transferase (gst), and that the combined effects of these two stressors would be additive.
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.
ANRS EPF-CO10 Pediatric Cohort and the ANRS EP47 VISCONTI study group et al., Paris, France. In Lancet Hiv, Jan 2016
METHODS: The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age.
Functional structure and physiological functions of mammalian wild-type HSP60.
Itoh et al., Akita, Japan. In Arch Biochem Biophys, Dec 2015
In the prokaryotic group I chaperonins, structural and reaction cycle analyses of GroEL and its co-chaperone GroES have been performed in detail.
Differential Function of Arabidopsis SERK Family Receptor-like Kinases in Stomatal Patterning.
Shan et al., College Station, United States. In Curr Biol, Oct 2015
We report here that the SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK) family RLKs regulate stomatal patterning downstream of EPF ligands and upstream of a MAP kinase cascade.
Competitive binding of antagonistic peptides fine-tunes stomatal patterning.
Torii et al., Seattle, United States. In Nature, Jul 2015
Here we report in Arabidopsis that Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)-ER module.
E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis.
Jung et al., Taejŏn, South Korea. In Bmc Cancer, 2014
RESULTS: Three VHL missense mutants (V155A, L158Q, and Q164R) are directly ubiquitinated by E2-EPF UCP (UCP) in vitro.
Versatile roles of the chaperonin GroEL in microorganism-insect interactions.
Gross et al., Würzburg, Germany. In Fems Microbiol Lett, 2014
It is an essential protein because in conjunction with the chaperonin 10 (Cpn10 or GroES) it forms a protein-folding machine required for correct folding of many proteins and for recycling of misfolded proteins.
Diverse roles of ERECTA family genes in plant development.
Shpak, Knoxville, United States. In J Integr Plant Biol, 2013
ERfs sense secreted cysteine-rich peptides from the EPF/EPFL family and transmit the signal through a MAP kinase cascade.
HSP60 as a drug target.
Minegishi et al., Japan. In Curr Pharm Des, 2012
HSP60 is also known to interact with HSP10.
Mix-and-match: ligand-receptor pairs in stomatal development and beyond.
Torii, Seattle, United States. In Trends Plant Sci, 2012
In Arabidopsis, two EPIDERMAL PATTERNING FACTOR (EPF) peptides, EPF1 and EPF2, are secreted from stomatal precursors enforcing proper stomatal patterning.
A tale of two systems: peptide ligand-receptor pairs in plant development.
Torii et al., Seattle, United States. In Cold Spring Harb Symp Quant Biol, 2011
In this review, we focus on two specific families of plant peptides: the CLAVATA3/ENDOSPERM SURROUNDING REGION (CLE) peptide family and the EPIDERMAL PATTERING FACTOR (EPF) family, along with their corresponding RLKs.
Macromolecular crowding extended to a heptameric system: the Co-chaperonin protein 10.
Wittung-Stafshede et al., Umeå, Sweden. In Biochemistry, 2011
Data show that that in presence of 300 mg/mL Ficoll the thermodynamic stability of each cpn10 monomer increases by over 30%, whereas the interfaces are stabilized by less than 10%.
HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes.
Kobayashi et al., Japan. In Biochem Biophys Res Commun, 2009
HSP10 was identified as a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes.
Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
Liu et al., Nanjing, China. In Gynecol Endocrinol, 2009
HSP10 protein was detected only in oocytes from human preantral follicles, whereas in antral follicles, it was localised in oocytes, granulosa cells, theca cells and stroma cells.
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3.
Congote et al., Montréal, Canada. In J Cell Physiol, 2009
Results describe a novel function of chaperonin 10 as a general differentiation factor, not limited to erythroid cells, and show how this biological effect is mediated by GSK-3alpha/beta.
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.
Horwich et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2008
the GroEL-GroES chamber behaves as a passive "Anfinsen cage" whose primary role is to prevent multimolecular association during folding.
Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial.
Feeney et al., Australia. In Lancet, 2006
BACKGROUND: Chaperonin 10 (heat shock protein 10, XToll) has anti-inflammatory properties related to the inhibition of Toll-like receptor signalling pathways.
pVHL's kryptonite: E2-EPF UCP.
Ohh, Toronto, Canada. In Cancer Cell, 2006
E2-EPF ubiquitin carrier protein (UCP) is a member of an E2 family of enzymes that catalyzes the ligation of ubiquitin to proteins targeted for destruction by the proteasome.
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis.
Im et al., Taejŏn, South Korea. In Nat Med, 2006
Here we show that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiquitin-mediated proteolysis in cells, thereby stabilizing HIF-1alpha.
Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae.
Hol et al., Seattle, United States. In Science, 1996
Members of the chaperonin-10 (cpn10) protein family, also called heat shock protein 10 and in Escherichia coli GroES, play an important role in ensuring the proper folding of many proteins.
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