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Chromosome 1 open reading frame 9

Encodes chlorophyllide a oxygenase which converts chlorophyllide a to chlorophyllide b by catalyzing two successive hydroxylations at the 7-methyl group of chlorophyllide a . Mutants are deficient in pigments that associate with thylakoid membrane proteins, lacking chlorophyll b and light-harvesting proteins of photosystem II. The protein was shown through cross-linking experiments to interact with Toc75, Toc34, Tic40, Tic20 and Tic22. (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, IgG1, fibrillin-1
Papers using CH1 antibodies
Fuzzy logic and maximum a posteriori-based image restoration for confocal microscopy
Tacchetti Carlo et al., In Traffic (Copenhagen, Denmark), 2005
... Tet-Off HeLa cells were transfected with pTRE-CH1 (50 μg) and pTK-Hyg (5 μg; Clontech Laboratories), as described ( ...
Papers on CH1
Singlet Oxygen-Induced Cell Death in Arabidopsis under High Light Stress is Controlled by OXI1 Kinase.
Havaux et al., Orsay, France. In Plant Physiol, Feb 2016
UNASSIGNED: Studies of the singlet oxygen (1O2)-overproducing flu and ch1 mutants of Arabidopsis thaliana have shown that 1O2-induced changes in gene expression can lead to either programmed cell death or acclimation.
A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages.
Zhu et al., Nanjing, China. In Plos One, Dec 2015
We screened the positive clone of anti-human TLR4 phagemid from a human phage-display antibody library using recombinant TLR4 protein, which was used as template cDNA for the amplification of variable regions of the heavy (VH) chain and light chain (VL), then coupled with highly conserved regions of the heavy chain domain 1 (CH1) and the light chain (CL), respectively.
Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.
Brindle et al., Memphis, United States. In Plos One, Dec 2015
Recently, genomic studies involving large numbers of ASD patient families have theoretically modeled CBP and its paralog p300 (EP300) as critical hubs in ASD-associated protein and gene interaction networks, and have identified de novo missense mutations in highly conserved residues of the CBP acetyltransferase and CH1 domains.
[Research on the Thermal Infrared Polarization Properties of Fresh Snow].
Zhao et al., In Guang Pu Xue Yu Guang Pu Fen Xi, Jul 2015
Four channels are considered in this study, their spectral response ranges are 8-14 microm for channel 1 (CH1), 11.5-12.5 microm for channel 2 (CH2), 10.3-11.5 microm for channel 3 (CH) and 8.2-9.2 microm for channel 4 (CH4).
Molecular mechanism and cellular function of MHCII ubiquitination.
Shin et al., San Francisco, United States. In Immunol Rev, Jul 2015
The ubiquitination is mediated by the membrane-associated RING-CH1 (MARCH1) ubiquitin ligase although it can be also mediated by the homologous ligase MARCH8 in model cell lines.
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.
Glennie et al., Leiden, Netherlands. In Cancer Cell, Feb 2015
Agonistic activity can be transferred from h2 to h1 by swapping their hinge and CH1 domains, and substitution of key hinge and CH1 cysteines generates homogenous h2 variants with distinct agonistic properties.
Reformatting Rituximab into Human IgG2 and IgG4 Isotypes Dramatically Improves Apoptosis Induction In Vitro.
Enenkel et al., Biberach an der Riß, Germany. In Plos One, 2014
The determinants for this behavior are located in the hinge region and CH1 domain of the heavy chain.
Key players of singlet oxygen-induced cell death in plants.
Havaux et al., Marseille, France. In Front Plant Sci, 2014
However, during the last 15 years, the isolation and characterization of two (1)O2-overproducing mutants in Arabidopsis thaliana, flu and ch1, has allowed the identification of genetically controlled (1)O2 cell death pathways and a (1)O2 acclimation pathway that are triggered at sub-cytotoxic concentrations of (1)O2.
Tregitope update: mechanism of action parallels IVIg.
De Groot et al., Providence, United States. In Autoimmun Rev, 2013
By comparing the human IgG Tregitopes (hTregitopes 167 and 289, located in the IgG CH1 and CH2 domains) and Fab to murine sequences, we identified class II-restricted murine Tregitope homologs (mTregitopes).
The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients.
Sleeman et al., Karlsruhe, Germany. In Oncogene, 2012
Relief of contact inhibition was associated with translocation of the Ier2 protein from the cytoplasm to the nucleus in both 3T3 fibroblasts and 1AS tumor cells
Introduction to heavy chain antibodies and derived Nanobodies.
Muyldermans et al., Brussels, Belgium. In Methods Mol Biol, 2011
By definition, a heavy chain antibody is devoid of a light chain and in the case of the heavy chain antibodies in camelids the CH1 domain is also missing.
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.
Brindle et al., Memphis, United States. In Cell Metab, 2011
In one model, the main CBP interaction with the glucagon-responsive factor CREB is not limiting for liver gluconeogenesis, whereas a second model posits that Ser436 in the CH1 (TAZ1) domain of CBP is required for insulin and the antidiabetic drug metformin to inhibit CREB-mediated liver gluconeogenesis.
Determination of a chloroplast degron in the regulatory domain of chlorophyllide a oxygenase.
Tanaka et al., Sapporo, Japan. In J Biol Chem, 2010
Determination of a chloroplast degron in the regulatory domain of chlorophyllide a oxygenase.
Loss of the N-terminal domain of chlorophyllide a oxygenase induces photodamage during greening of Arabidopsis seedlings.
Tanaka et al., Sapporo, Japan. In Bmc Plant Biol, 2007
Data show that the A domain of CAO is essential in the control of chlorophyll biosynthesis and in the survival of seedlings during de-etiolation especially under strong illumination.
Radioiodinated anti-TAG-72 humanized CH2 domain-deleted antibody
Cheng, Bethesda, United States. In Unknown Journal, 2007
The light chain constant domain was a human Cκ, and the human γ1 chain was genetically modified to produce a heavy chain composed of a CH1 domain followed by a partial IgG1 hinge region tethered to the CH3 heavy chain domain by addition of a flexible 10-amino-acid GGGSSGGGSG spacer (22).
A role for chlorophyllide a oxygenase in the regulated import and stabilization of light-harvesting chlorophyll a/b proteins.
Reinbothe et al., Bayreuth, Germany. In Proc Natl Acad Sci U S A, 2006
CAO is involved in the regulated import and stabilization of the chlorophyllide b-binding light-harvesting proteins Lhcb1 (LHCII) and Lhcb4 (CP29) in chloroplasts.
Effects of chlorophyllide a oxygenase overexpression on light acclimation in Arabidopsis thaliana.
Tanaka et al., Sapporo, Japan. In Photosynth Res, 2005
The mechanism which regulates Chl a/b ratios and whether the changes in Chl a/b ratios are essential in regulation of LHC accumulation during light acclimation was studied.
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Livingston et al., United States. In Cancer Cell, 2004
At a molecular level, chetomin disrupts the structure of the CH1 domain of p300 and precludes its interaction with HIF, thereby attenuating hypoxia-inducible transcription.
Suppression of tumor growth through disruption of hypoxia-inducible transcription.
Livingston et al., Boston, United States. In Nat Med, 2000
Our data indicate that specific blockade of the interaction of hypoxia-inducible factor with the CH1 domain of its p300 and CREB binding protein transcriptional coactivators leads to attenuation of hypoxia-inducible gene expression and diminution of tumor growth.
Naturally occurring antibodies devoid of light chains.
Hamers et al., Brussels, Belgium. In Nature, 1993
Camel heavy-chain IgGs lack CH1, which in one IgG class might be structurally replaced by an extended hinge.
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