Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2
Bethesda, United States. In Unknown Journal, 2011
Gene expression profiling revealed that ML245 regulated the expression of several pro-apoptotic/mitochondrial maintenance factors (such as caspase recruitment domain family member 10, activating transcription factor 4, mitochondrial ribosomal protein MRPL12), and DNA-modifying enzymes (such as Early Growth Response 1, zinc finger-containing proteins ZNF295 and CGRRF1, and TBP-associated factor 1D), in the CSC-like cell line and not the isogenic control cell line.
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1).
Oslo, Norway. In J Pathol, 2006
Furthermore, by a discovery-based global approach, comparing cDNA microarray expression profiles of two germ cell tumour cell lines before and after treatment with the demethylating agent 5-aza-2'-deoxycytidine, a gene list of potentially epigenetic targets was identified, from which CGGBP1, CGRRF1, SMARCC2, SORBS1, and XPA were analysed further.