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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein kinase, cGMP-dependent, type II

cGKII, cGMP-dependent protein kinase II, type II cGMP-dependent protein kinase, PRKG2, cGMP-dependent protein kinase type II
may regulate renin release and renal ion transport [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, Cystic Fibrosis Transmembrane Conductance Regulator, CAN, HAD, ACID
Papers on cGKII
Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells.
New
Chen et al., Zhenjiang, China. In Mol Med Report, Jan 2016
UNASSIGNED: Our previous study demonstrated that type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF)-induced phosphorylation/activation of epidermal growth factor receptor (EGFR).
Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase.
New
Chen et al., Zhenjiang, China. In Oncol Lett, Jul 2015
UNASSIGNED: Nitric oxide (NO) may activate soluble guanylyl cyclase (sGC), resulting in the increase of intracellular cyclic guanosine monophosphate (cGMP), a key molecule in the activation of type II cGMP-dependent protein kinase (PKG II).
Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors.
New
Ziff et al., München, Germany. In Proc Natl Acad Sci U S A, Apr 2015
We have studied mice lacking cGMP-dependent kinase II (cGKII), which phosphorylates GluA1, a subunit of AMPA receptors (AMPARs), and promotes hippocampal long-term potentiation (LTP) through AMPAR trafficking.
Phenotypic variability in a Hungarian patient with the 4q21 microdeletion syndrome.
Melegh et al., Pécs, Hungary. In Mol Cytogenet, 2014
A minimal critical region of 1.37 Mb accounting for the common features with 5 known genes (PRKG2, RASGEF1B, HNRNPD, HNRPDL, and ENOPH1) has been described so far.
Detection of selection signatures in dairy and beef cattle using high-density genomic information.
Berry et al., Beijing, China. In Genet Sel Evol, 2014
DGAT1, ABCG2, MSTN, CAPN3, FABP3, CHCHD7, PLAG1, JAZF1, PRKG2, ACTC1, TBC1D1, GHR, BMP2, TSG1, LYN, KIT and MC1R that play a role in milk production, reproduction, body size, muscle formation or coat color.
ANP and CNP activate CFTR expressed in Xenopus laevis oocytes by direct activation of PKA.
Forrest et al., New Haven, United States. In J Recept Signal Transduct Res, 2014
Natriuretic peptides could activate CFTR by 1) cGMP cross-activation of protein kinase A (PKA), 2) cGMP activation of cGMP-dependent protein kinase II, 3) cGMP inhibition of phosphodiesterase type III (PDE3), or 4) direct activation of CFTR.
Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.
Schlossmann et al., Regensburg, Germany. In Plos One, 2014
We investigated the effect of cCMP on purified cyclic nucleotide-dependent protein kinases and lung and jejunum tissues of wild type (WT), cGKI-knockout (cGKI KO) and cGKII-knockout (cGKII KO) mice.
Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2.
Reecy et al., Ames, United States. In Bmc Res Notes, 2014
BACKGROUND: Kinase activity of cGMP-dependent, type II, protein kinase (PRKG2) is required for the proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification.
Neurophysiology of HCN channels: from cellular functions to multiple regulations.
Review
Hu et al., Chongqing, China. In Prog Neurobiol, 2014
In the next section, we discuss how the intracellular signals, especially recent findings concerning protein kinases and interacting proteins such as cGKII, Ca(2+)/CaMKII and TRIP8b, regulate function and expression of HCN channels, and subsequently provide an overview of the effects of neurotransmitters on HCN channels and their corresponding intracellular mechanisms.
cGMP-dependent protein kinases (cGK).
Review
Wegener et al., München, Germany. In Methods Mol Biol, 2012
Two genes-prkg1 and prkg2-code for cGKs, namely, cGKI and cGKII.
Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.
GeneRIF
Browning et al., Augusta, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon.
Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.
GeneRIF
Tao et al., Zhenjiang, China. In Oncol Rep, 2012
The results suggest that PKGII inhibits EGF-induced MAPK/JNK-mediated signal transduction and further confirmed that PKGII can block the activation of EGFR.
Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.
GeneRIF
Sang et al., Zhenjiang, China. In Oncol Rep, 2012
PKG II inhibits the proliferation of gastric cancer cells through blocking EGF-triggered MAPK signal transduction.
Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
GeneRIF
Siragy et al., Charlottesville, United States. In Hypertension, 2012
Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
8.6Mb interstitial deletion of chromosome 4q13.3q21.23 in a boy with cognitive impairment, short stature, hearing loss, skeletal abnormalities and facial dysmorphism.
Review
GeneRIF
Limon et al., Gdańsk, Poland. In Genet Couns, 2010
As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype.
Regulation of electroneutral NaCl absorption by the small intestine.
Review
Romero et al., Yokohama, Japan. In Annu Rev Physiol, 2010
Electroneutral NaCl absorption and Cl(-) secretion by CFTR are oppositely regulated by the autonomic nerve system, the immune system, and the endocrine system via PKAα, PKCα, cGKII, and/or SGK1.
cGK substrates.
Review
Desch et al., Regensburg, Germany. In Handb Exp Pharmacol, 2008
Several substrates of cGKI and cGKII were identified meanwhile.
Function of cGMP-dependent protein kinases as revealed by gene deletion.
Review
Impact
Schlossmann et al., München, Germany. In Physiol Rev, 2006
Mutant and chimeric cGK proteins generated by molecular biology techniques yielded important biochemical knowledge, such as the function of the NH(2)-terminal domains of cGKI and cGKII, the identity of the cGMP-binding sites of cGKI, and the substrate specificity of the enzymes.
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
Impact
Fässler et al., München, Germany. In Science, 1997
The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates.
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