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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger, HIT-type containing 1

CGI-I
Top mentioned proteins: HAD, AGE, hAM, OUT, Rab3D
Papers on CGI-I
Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review.
New
Hellings et al., Columbus, United States. In J Autism Dev Disord, Jan 2016
At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I).
Response to intravenous fentanyl infusion predicts subsequent response to transdermal fentanyl.
New
Okamoto et al., Sagamihara, Japan. In J Anesth, Jan 2016
Pain intensity before and after FENiv and 2 weeks after FENtd, and the response to treatment, were assessed by the numerical rating scale (NRS), clinical global impression-improvement scale (CGI-I), satisfaction scale (SS), and adverse effects.
Pharmacotherapy for anxiety and comorbid alcohol use disorders.
Review
Stein et al., Cape Town, South Africa. In Cochrane Database Syst Rev, 2014
Overall, 70% of participants included in the review were male.There was very low quality evidence for an effect of paroxetine on global clinical response to treatment, as assessed by the Clinical Global Impressions - Improvement scale (CGI-I).
Effect of prior exposure to dopamine agonists on treatment with gabapentin enacarbil in adults with moderate-to-severe primary restless legs syndrome: pooled analyses from 3 randomized trials.
Shang et al., Houston, United States. In J Clin Mov Disord, 2014
Within DA-naive/DA-exposed patients we investigated the co-primary end points from the pivotal trials: mean change from baseline to week 12 in International RLS (IRLS) Rating Scale total score and proportion of responders ("much"/"very much" improved) on the investigator-rated Clinical Global Impression-Improvement (CGI-I) scale.
An 8-Week Randomized, Double-Blind Trial Comparing Efficacy, Safety, and Tolerability of 3 Vilazodone Dose-Initiation Strategies Following Switch From SSRIs and SNRIs in Major Depressive Disorder.
Patkar et al., Pusan, South Korea. In Prim Care Companion Cns Disord, 2014
The secondary efficacy measures were changes in Clinical Global Impressions-Severity (CGI-S), CGI-Improvement (CGI-I), and Hamilton Anxiety Rating Scale (HARS) scores.
Efficacy of Desvenlafaxine 50 mg/d Versus Placebo in the Long-Term Treatment of Major Depressive Disorder: A Randomized, Double-Blind Trial.
Tourian et al., Paris, France. In Prim Care Companion Cns Disord, 2014
Depressive symptoms were evaluated using the HDRS-17, 6-item HDRS, and Clinical Global Impressions-Severity of Ilness and -Improvement (CGI-S, CGI-I).
A systematic review of the clinical relevance of repetitive transcranial magnetic stimulation.
Review
Poole et al., United Kingdom. In Acta Psychiatr Scand, 2014
The clinical relevance of findings in the rTMS literature was assessed by translating Hamilton Depression Rating Scale (HAMD) data into Clinical Global Impression-Improvement scale (CGI-I) scores.
Systematic evidence synthesis of treatments for ADHD in children and adolescents: indirect treatment comparisons of lisdexamfetamine with methylphenidate and atomoxetine.
Review
Hodgkins et al., Sheffield, United Kingdom. In Curr Med Res Opin, 2014
Sufficient data were identified for each outcome: ADHD-RS, 16 trials; CGI-I, 20 trials; all-cause withdrawals, 28 trials; and withdrawals due to adverse events, 27 trials.
Gabapentin enacarbil: in patients with restless legs syndrome.
Review
Scott, North Shore, New Zealand. In Cns Drugs, 2012
In the 12-week Patient Improvements in Vital Outcomes following Treatment (PIVOT) RLS I and II trials in adult patients with moderate to severe primary RLS (n > 500 total evaluable), once-daily gabapentin enacarbil 600 or 1,200 mg significantly improved mean International Restless Legs Scale (IRLS) total scores compared with placebo, with significantly higher investigator-rated Clinical Global Impression-Improvement (CGI-I) responder rates in gabapentin enacarbil groups than in placebo groups.
Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder.
Review
Citrome, Valhalla, United States. In Int J Clin Pract, 2012
ES differences for Clinical Global Impressions-Improvement (CGI-I) were similar.
p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.
GeneRIF
Nebreda et al., Madrid, Spain. In Cell Cycle, 2007
Study reports that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A).
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
GeneRIF
Nebreda et al., Madrid, Spain. In Embo J, 2007
p18(Hamlet) is a new cell-fate regulator that links the p38 MAPK and p53 pathways and contributes to the establishment of p53-regulated stress responses.
Sertraline treatment of major depression in patients with acute MI or unstable angina.
Impact
Sertraline Antidepressant Heart Attack Randomized Trial (SADHEART) Group et al., New York City, United States. In Jama, 2002
MAIN OUTCOME MEASURES: The primary (safety) outcome measure was change from baseline in left ventricular ejection fraction (LVEF); secondary measures included surrogate cardiac measures and cardiovascular adverse events, as well as scores on the HAM-D scale and Clinical Global Impression Improvement scale (CGI-I) in the total randomized sample, in a group with any prior history of MDD, and in a more severe MDD subgroup defined a priori by a HAM-D score of at least 18 and history of 2 or more prior episodes of MDD.
Risperidone in children with autism and serious behavioral problems.
Impact
Research Units on Pediatric Psychopharmacology Autism Network et al., Los Angeles, United States. In N Engl J Med, 2002
The primary outcome measures were the score on the Irritability subscale of the Aberrant Behavior Checklist and the rating on the Clinical Global Impressions - Improvement (CGI-I) scale at eight weeks.
Effectiveness of St John's wort in major depression: a randomized controlled trial.
Impact
Halbreich et al., Nashville, United States. In Jama, 2001
Secondary measures included the Beck Depression Inventory (BDI), Hamilton Rating Scale for Anxiety (HAM-A), the Global Assessment of Function (GAF) scale, and the Clinical Global Impression-Severity and -Improvement scales (CGI-S and CGI-I).
Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial.
Impact
Farfel et al., Charleston, United States. In Jama, 2000
MAIN OUTCOME MEASURES: Baseline-to-end-point changes in CAPS-2 total severity score, Impact of Event Scale total score (IES), and Clinical Global Impression-Severity (CGI-S), and CGI-Improvement (CGI-I) ratings, compared by treatment vs placebo groups.
Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial.
Impact
Steiner et al., Durham, United States. In Jama, 1998
MAIN OUTCOME MEASURES: The Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), the National Institute of Mental Health Global Obsessive Compulsive Scale (NIMH GOCS), and the NIMH Clinical Global Impressions of Severity of Illness (CGI-S) and Improvement (CGI-I) rating scales.
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