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CGG triplet repeat binding protein 1

CGGBP1, p20-CGGBP, CGGBP
CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: FMR1, CAN, NotI, SET, LRP15
Papers on CGGBP1
Defining the role of the CGGBP1 protein in FMR1 gene expression.
New
Tabolacci et al., Roma, Italy. In Eur J Hum Genet, Sep 2015
To identify structure-specific proteins that could recruit components of the silencing machinery we investigated the role of CGGBP1 in FMR1 gene transcription.
CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.
Singh et al., Uppsala, Sweden. In Bmc Genomics, 2014
BACKGROUND: CGGBP1 is a repetitive DNA-binding transcription regulator with target sites at CpG-rich sequences such as CGG repeats and Alu-SINEs and L1-LINEs.
CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.
Review
Westermark et al., Uppsala, Sweden. In Ups J Med Sci, 2014
We review here the work done on CGG repeats and associated proteins with special focus on a factor called CGGBP1.
Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs.
Singh et al., Uppsala, Sweden. In Cell Cycle, 2014
ABSTRACT CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response, cytokinesis, telomeric integrity and transcription.
Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds.
GemQual Consortium et al., Madrid, Spain. In Mol Biol Rep, 2014
Twelve genes were found associated with different lipid and meat quality traits, and among these stand out the considerable effect of CAST on fatness score, CGGBP1 on growth traits, HSPB1 on the percentage of lauric acid (12:0) and phospholipid docosahexaenoic acid (DHA 22:6 n - 3), RORA on the ratio of light absorption (K) to light scattering (S) (K/S), and TNFA on lightness (L*).
[Over-expressed microRNA-7 inhibits the growth of human lung cancer cells via suppressing CGGBP1 expression].
Xu et al., Zunyi, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2014
Moreover, the expressions of nuclear antigen Ki-67 and CGG binding protein 1 (CGGBP1) were detected by immunofluorescence assay.
CGGBP1 phosphorylation constitutes a telomere-protection signal.
Westermark et al., Uppsala, Sweden. In Cell Cycle, 2013
We demonstrate here that in normal human fibroblasts, telomeric ends are protected by phosphorylation of CGG triplet repeat-binding protein 1 (CGGBP1) at serine 164 (S164).
Novel tumor suppressor candidates on chromosome 3 revealed by NotI-microarrays in cervical cancer.
Zabarovsky et al., Moscow, Russia. In Epigenetics, 2013
A set of seven potential markers (LRRN1, PRICKLE2, VHL, BHLHE40, RBSP3, CGGBP1 and SOX14) is promising for discrimination of ADC and SCC.
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.
Zabarovsky et al., Stockholm, Sweden. In Epigenetics, 2012
A comprehensive statistical analysis suggested the set of 19 gene markers, ANKRD28, BHLHE40, CGGBP1, RBSP3, EPHB1, FGD5, FOXP1, GORASP1/TTC21, IQSEC1, ITGA9, LOC285375, LRRC3B, LRRN1, MITF, NKIRAS1/RPL15, TRH, UBE2E2, VHL, WNT7A, to allow early detection, tumor progression, metastases and to discriminate between SCC and ADC with sensitivity and specificity of 80-100%.
NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.
Zabarovsky et al., Stockholm, Sweden. In Int J Mol Sci, 2011
To distinguish between Stages I + II and Stages III + IV of ovarian cancer the most perspective set of biomarkers would include LOC285205, CGGBP1, EPHB1 and NKIRAS1/RPL15.
CGGBP1 is a nuclear and midbody protein regulating abscission.
Westermark et al., Uppsala, Sweden. In Exp Cell Res, 2011
We report here an unexpected expression pattern and function of the transcription repressor protein CGG triplet repeat-binding protein 1 (CGGBP1), in normal human fibroblasts.
CGGBP1 regulates cell cycle in cancer cells.
GeneRIF
Westermark et al., Uppsala, Sweden. In Bmc Mol Biol, 2010
CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase.
Characterization of the 3p12.3-pcen region associated with tumor suppression in a novel ovarian cancer cell line model genetically modified by chromosome 3 fragment transfer.
Tonin et al., Montréal, Canada. In Mol Carcinog, 2009
interval to a 16.1 Mb common region containing 12 known or hypothetical genes: 3ptel-ROBO2-ROBO1-GBE1-CADM2-VGLL3-CHMP2B-POU1F1-HTR1F-CGGBP1-ZNF654-C3orf38-EPHA3-3pcen.
Fragile X gene stability in Basque Valleys: prevalence of premutation and intermediate alleles.
GeneRIF
Gónzalez et al., Bilbao, Spain. In Hum Biol, 2008
Differences in factors implicated in CGG repeat instability--CGG repeat size, XS548/FRAXAC1 haplotypes, and AGG interspersion pattern-are present in the Basque populations analyzed.
A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions.
Westermark et al., Uppsala, Sweden. In Plos One, 2008
METHODOLOGY/PRINCIPAL FINDINGS: By combining microarray expression profiling and a yeast-two-hybrid screen, we identified that NFIX and its interactions with CGGBP1 and HMGN1 regulate expression of HSF1.
[The role of ZF5 and CGGBP-20 transcription factors in expression regulation of human FMR1 gene responsible for X-fragile syndrome].
GeneRIF
Perevozchikov et al., In Tsitologiia, 2008
CGGBP-20 downregulates the activity of 5'-region of FMR1 gene in the presence of GCC-triplets only.
Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1).
GeneRIF
Doerfler et al., Köln, Germany. In Genomics, 2004
CGGBP1 was mapped to chromosome 3p and a sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity.
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