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Chorionic gonadotropin, beta polypeptide 2

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: chromogranin B, HCG, hCG-beta, LH beta, CAN
Papers on CGB2
Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.
Iles et al., Houston, United States. In Anticancer Res, 2014
hCGβ is encoded by six homologous CGB genes, with poorly-understood variable transcriptionally active expression profiles; CGB1 and CGB2 have always been considered pseudogenes.
A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis.
Seker et al., In Conf Proc Ieee Eng Med Biol Soc, 2013
Results show that cell regulation FOXQ1 may inhibit the expression of focusyltransferase-6 (FUT6) and that ABCG1 ATP-binding cassette sub-family G may also play inhibitory role against NR2E3 nuclear receptor sub-family 2 and CGB2 Chromatin Gonadotrophin.
Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.
Jankowska et al., Poznań, Poland. In Int J Mol Sci, 2012
Recent studies revealed that CGB1 and CGB2, originally considered as pseudogenes, might also be active, however, the protein products of these genes have not yet been identified.
Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.
Laan et al., Tartu, Estonia. In Mol Hum Reprod, 2008
HCG beta subunit is encoded by CGB, CGB5, CGB7 and CGB8 genes located at 19q13.3 in a common genome cluster with beta subunit non-coding CGB1 and CGB2.
The evolution and genomic landscape of CGB1 and CGB2 genes.
Laan et al., Tartu, Estonia. In Mol Cell Endocrinol, 2007
In silico prediction of putative transcription factor binding sites supports the hypothesis that CGB1 and CGB2 gene products are expressed in, and may contribute to, implantation and placental development.
Expression of beta-subunit of HCG genes during normal and failed pregnancy.
Laan et al., Tartu, Estonia. In Hum Reprod, 2005
The function of two additional gene copies, CGB1 and CGB2, is still unknown.
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