Age-related macular degeneration: Complement in action.
San Francisco, United States. In Immunobiology, Jan 2016
Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population.
[Atypical HUS caused by complement-related abnormalities].
Nara, Japan. In Rinsho Ketsueki, Feb 2015
Many aHUS cases (approximately 70%) are reportedly caused by uncontrolled complement activation due to genetic mutations in the alternative pathway, including complement factor H (CFH), complement factor I (CFI), membrane cofactor protein (MCP), thrombomodulin (THBD), complement component C3 (C3), and complement factor B (CFB).
Polo-like kinase 4 inhibition: a strategy for cancer therapy?
Baltimore, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Mason and colleagues describe the development of a Polo-like kinase 4 (PLK4) inhibitor (CFI-400945), with promising activity against tumors formed in mice from patient-derived tumor tissue.
Protective molecules and their cognate antibodies: new players in autoimmunity.
Padova, Italy. In Auto Immun Highlights, 2010
Complement component C1q, Creactive protein (CRP), serum amyloid P (SAP), mannose-binding lectin (MBL), apolipoprotein A-1 (Apo A-1) and long pentraxin 3 (PTX3) are molecules involved in the removal of apoptotic bodies and pathogens, and in other antiinflammatory pathways.