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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

OTU domain containing 7B

Cezanne
Top mentioned proteins: Ubiquitin, CAN, A20, NF-kappaB, SBS
Papers on Cezanne
Cezanne regulates E2F1-dependent HIF2α expression.
New
Rocha et al., Frankfurt am Main, Germany. In J Cell Sci, Sep 2015
Here, we show that expression of HIF2α (encoded by EPAS1) is regulated by the deubiquitylase Cezanne (also known as OTUD7B) in an E2F1-dependent manner.
Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of Sphingolipids.
New
Jiang et al., West Lafayette, United States. In J Immunol, Aug 2015
Knockout of A20 partially diminished γTE's anti-NF-κB effect, but γTE increased another NF-κB inhibitor, Cezanne, in A20(-/-) cells.
Proinflammatory mediators alter expression of nuclear factor kappa B-regulating deubiquitinases in sinonasal epithelial cells.
New
Turner et al., Zhengzhou, China. In Int Forum Allergy Rhinol, Jul 2015
Its activity is tightly regulated by a family of deubiquitinating enzymes (A20, Cezanne, cylindromatosis [CYLD]) that function in a negative-feedback loop, a process that prevents chronic and systemic inflammation.
ERES: sites for autophagosome biogenesis and maturation?
New
Reggiori et al., Utrecht, Netherlands. In J Cell Sci, Feb 2015
128, 193-205) and 'WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome' by Tassula Proikas-Cezanne et al. (J.
Membrane dynamics in autophagosome biogenesis.
Review
New
Simonsen et al., Oslo, Norway. In J Cell Sci, Feb 2015
128, 185-192) and 'WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome' by Tassula Proikas-Cezanne et al. (J.
Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.
Chin et al., Dundee, United Kingdom. In Nat Commun, 2014
We show that the ubiquitination of DIX at K54 blocks its polymerization in solution, whereas DIX58-Ub remains oligomerization-competent. DUB profiling identified 28 DUBs that cleave DIX-ubiquitin conjugates, half of which prefer, or are specific for, DIX54-Ub, including Cezanne and CYLD.
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma.
Guo et al., Xinhui, China. In J Transl Med, 2014
BACKGROUND: Deubiquitinases, such as CYLD, A20 and Cezanne, have emerged as negative regulators that balance the strength and duration of NF-κB signaling through feedback mechanisms.
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.
Komander et al., Frankfurt am Main, Germany. In Embo Rep, 2014
Here, we demonstrate that the deubiquitinase Cezanne regulates HIF-1α homeostasis.
The biology of A20-like molecules.
Review
Evans et al., In Adv Exp Med Biol, 2013
The human genome contains 15 members of the OTU family including the deubiquitinating enzymes Cezanne, VCIP135 and Otubain 1.
Ammonium as sole N source improves grain quality in wheat.
Estavillo et al., Bilbao, Spain. In J Sci Food Agric, 2013
RESULTS: This experiment demonstrates that Cezanne wheat plants growing with ammonium as exclusive N source are able to achieve the same yield as plants growing with nitrate and that individual wheat plants grown in irrigated pots can efficiently use late N applied in GS37.
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Evans et al., Sheffield, United Kingdom. In Circ Res, 2013
OBJECTIVE: In this study, we tested the hypothesis that endothelial activation in response to hypoxia-reoxygenation can be influenced by Cezanne, a deubiquitinating enzyme that cleaves ubiquitin from specific modified proteins.
Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts.
Sahai et al., London, United Kingdom. In Oncogene, 2013
Here, we identify an E3 ligase, Traf6 and a de-ubiquitinating enzyme, Cezanne/ZA20D1, as important regulators of this process in organotypic models.
miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops.
Li et al., Guangzhou, China. In Cell Res, 2013
Deubiquitinases, such as CYLD, A20 and Cezanne, have emerged as important negative regulators that balance the strength and the duration of NF-κB signaling through feedback mechanisms.
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.
Yarden et al., Israel. In Oncogene, 2012
Using RNA interference screens, we identified a deubiquitinating enzyme, Cezanne-1, that opposes receptor degradation and enhances EGFR signaling.
[Expression of zinc finger protein A20 in pediatric inflammatory bowel disease].
GeneRIF
Huang et al., Shanghai, China. In Zhonghua Er Ke Za Zhi, 2011
There is an excessive inflammatory response but insufficient up-regulation of A20 expression in inflammatory bowel disease patients.
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
GeneRIF
Ting et al., Chapel Hill, United States. In J Biol Chem, 2011
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
GeneRIF
Komander et al., Cambridge, United Kingdom. In Nat Struct Mol Biol, 2010
Cezanne is identified as the first deubiquitinase with Lys11-linkage preference.
Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.
GeneRIF
Evans et al., London, United Kingdom. In J Biol Chem, 2008
H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha.
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.
GeneRIF
Evans et al., London, United Kingdom. In J Biol Chem, 2008
Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination
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