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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholesteryl ester transfer protein, plasma

Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, HAD, AGE, fibrillin-1, CAN
Papers using CETP antibodies
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice
Oliveira Helena CF et al., In Lipids in Health and Disease, 2002
... Hemizygous human CETP transgenic mice, line 5203, C57BL6/J ...
Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney.
Dunbrack Roland L., In PLoS Computational Biology, 1998
... Prediction of CETP Inhibitor Drug Off-TargetsThe binding site for CETP inhibitors on ...
Papers on CETP
Cholesteryl ester transfer protein gene polymorphism (I405V) and premature coronary artery disease in an Iranian population.
Jalali et al., Tehrān, Iran. In Bosn J Basic Med Sci, Feb 2016
UNASSIGNED: The effect of human cholesteryl ester transfer protein (CETP) expression on atherogenesis is still under debate.
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.
Günel et al., New Haven, United States. In J Hum Genet, Feb 2016
Whole-exome sequencing revealed a novel homozygous missense mutation in FTO and a nonsense mutation in the cholesteryl ester transfer protein (CETP).
Anacetrapib for the treatment of dyslipidaemia: the last bastion of the cholesteryl ester transfer protein inhibitors?
Burnett et al., Perth, Australia. In Expert Opin Pharmacother, Jan 2016
INTRODUCTION: Inhibition of cholesteryl ester transfer protein (CETP) has emerged as a potential way to decrease cardiovascular risk by raising high density lipoprotein (HDL) cholesterol and lowering low density lipoprotein (LDL) cholesterol concentrations.
Cholesteryl Ester Transfer Protein (CETP) expression does not affect glucose homeostasis and insulin secretion: studies in human CETP transgenic mice.
Oliveira et al., Campinas, Brazil. In Lipids Health Dis, Dec 2015
BACKGROUND: Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of triglycerides for esterified cholesterol between HDL and apoB-lipoproteins.
Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.
Valladares-Salgado et al., Houston, United States. In Sci Rep, Dec 2015
Genome-wide significant signals were observed in or near CELSR2, ZNF259/APOA5, KANK2/DOCK6 and NCAN/MAU2 for total cholesterol, LPL, ABCA1, ZNF259/APOA5, LIPC and CETP for HDL cholesterol, CELSR2, APOB and NCAN/MAU2 for LDL cholesterol, and GCKR, TRIB1, ZNF259/APOA5 and NCAN/MAU2 for triglycerides.
What does the future hold for cholesteryl ester transfer protein inhibition?
Kastelein et al., Naarden, Netherlands. In Curr Opin Lipidol, Dec 2015
PURPOSE OF REVIEW: This article summarizes the latest studies relevant to cholesteryl ester transfer protein (CETP) inhibition and cardiovascular risk and proposes a series of patient populations that might eventually derive benefits from CETP inhibition.
Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options.
Mikhailidis et al., Birmingham, United States. In Expert Opin Pharmacother, Dec 2015
This situation has generated an interest in finding novel approaches of combining statins with other lipid-lowering agents, or finding new lipid and non-lipid targets, such as triglycerides, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, proprotein convertase subtilisin/kexin type 9 (PCSK9) gene, cholesterol ester transfer protein (CETP), lipoprotein (a), fibrinogen or C-reactive protein.
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial.
Barter et al., Amsterdam, Netherlands. In Lancet, Sep 2015
We assessed the safety, tolerability and efficacy of a novel cholesterol esterase transfer protein (CETP) inhibitor TA-8995 in patients with mild dyslipidaemia.
The Effect of Inflammation and Infection on Lipids and Lipoproteins
Grunfeld et al., Madagascar. In Unknown Journal, Jul 2015
LDL levels are frequently decreased but the prevalence of small dense LDL is increased due to cholesterol ester transfer protein (CETP) mediated exchange of triglycerides from triglyceride rich lipoproteins to LDL followed by triglyceride hydrolysis.
[Consecutive formation of the functions of high-, low-density and very-low-density lipoproteins during phylogenesis. Unique algorithm of the effects of lipid-lowering drugs].
Aripovsky et al., In Ter Arkh, 2014
Active uptake of polyenoic FA (PUFA) required the following: a) PUFA re-esterified from polar phospholipids into nonpolar cholesteryl polyesters (poly-CLE), b) a novel protein, cholesteryl ester transfer protein (CETP), initiated poly-CLE transformation from HDL to LDL.
HDL and glucose metabolism: current evidence and therapeutic potential.
Kingwell et al., Melbourne, Australia. In Front Pharmacol, 2014
The key clinically relevant observations are that both acute HDL elevation via short-term reconstituted HDL (rHDL) infusion and chronically raising HDL via a cholesteryl ester transfer protein (CETP) inhibitor reduce blood glucose in individuals with type 2 diabetes mellitus (T2DM).
Effects of dalcetrapib in patients with a recent acute coronary syndrome.
dal-OUTCOMES Investigators et al., Denver, United States. In N Engl J Med, 2012
Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes.
New molecular insights into CETP structure and function: a review.
Kane et al., San Francisco, United States. In J Lipid Res, 2012
CETP structure and function
Constitutive inhibition of plasma CETP by apolipoprotein C1 is blunted in dyslipidemic patients with coronary artery disease.
Lagrost et al., Bordeaux, France. In J Lipid Res, 2012
apoC1 as a CETP inhibitor no longer operates on cholesterol redistribution in high-risk patients with dyslipidemia
Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population.
Yang et al., Xi'an, China. In J Zhejiang Univ Sci B, 2012
in the present study, the TaqIB polymorphism of CETP was found to be associated with coronary artery disease in the Chinese population
A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.
Sanghera et al., Oklahoma City, United States. In Plos One, 2011
A strong association of CETP rs3764261 with high-density lipoprotein cholesterol.
[CETP gene TaqIB polymorphism and plasma lipids in patients with overweight and obesity].
Stolarska et al., Warsaw, Poland. In Rocz Panstw Zakl Hig, 2011
Results indicate that in obese men CETP gene Tag1B polymorphism may be an independent factor influencing HDL-cholesterol.
Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial.
Nissen et al., Cleveland, United States. In Jama, 2011
CONTEXT: Interest remains high in cholesteryl ester transfer protein (CETP) inhibitors as cardioprotective agents.
Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial.
dal-PLAQUE Investigators et al., New York City, United States. In Lancet, 2011
BACKGROUND: Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein cholesterol (HDL-C).
Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.
Lipton et al., United States. In Jama, 2010
This preliminary report suggests that CETP V405 valine homozygosity is associated with slower memory decline and lower incident dementia and AD risk.
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