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Carboxylesterase 5A

CES7, CES5, Carboxylesterase 5
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: ACID, Carboxylesterase, ES-31, CES6, HAD
Papers on CES7
Accelerated evolution of CES7, a gene encoding a novel major urinary protein in the cat family.
Murphy et al., United States. In Mol Biol Evol, 2011
We sequenced the gene encoding cauxin, CES7, in 22 species representing all major felid lineages, and multiple outgroups and showed that it has undergone rapid evolutionary change preceding and during the diversification of the cat family.
Identification and characterization of a novel non-coding RNA involved in sperm maturation.
Zhang et al., Shanghai, China. In Plos One, 2010
An epididymis-specific carboxylesterase named CES7 had 100% cDNA sequence homology at the 3'end with HongrES2 and its protein product could be downregulated by HongrES2 via mil-HongrES2.
Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition.
Miyazaki et al., Suita, Japan. In Genes Cells, 2010
In a search for genes specifically expressed in mouse embryonic stem cells, we identified one we called Ces5.
Identification and characterization of an epididymis-specific gene, Ces7.
Zhang et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2009
Here, a novel rat epididymis-specific gene named Ces7 was cloned and characterized.
Baculo-expression and enzymatic characterization of CES7 esterase.
Zhang et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2009
Recently, a novel epididymis-specific gene named Ces7 was cloned and characterized, which belongs to the carboxylesterase family.
A new class of mammalian carboxylesterase CES6.
Vandeberg et al., San Antonio, United States. In Comp Biochem Physiol Part D Genomics Proteomics, 2009
Four CES classes have been previously described, namely CES1 (major liver form); CES2 (major intestinal form); CES3 (highest activity in the colon); and CES5, a secreted enzyme found in mammalian kidney and male reproductive fluids.
Bovine Carboxylesterases: Evidence for Two CES1 and Five Families of CES Genes on Chromosome 18.
Vandeberg et al., San Antonio, United States. In Comp Biochem Physiol Part D Genomics Proteomics, 2009
Two CES gene clusters were observed on chromosome 18: CES5-CES1.1-CES1.2 and CES2-CES3-CES6.
Horse carboxylesterases: evidence for six CES1 and four families of CES genes on chromosome 3.
Vandeberg et al., San Antonio, United States. In Comp Biochem Physiol Part D Genomics Proteomics, 2009
The horse genome also showed evidence for three other CES gene classes: CES5, located in tandem with the CES1 gene cluster; and CES2 and CES3, located more than 9 million base pairs downstream on chromosome 3. Horse CES2, CES3 and CES5 gene products shared 42-46% identity with each other, and with the CES1 protein subunits.
Mammalian carboxylesterase 5: comparative biochemistry and genomics.
Vandeberg et al., San Antonio, United States. In Comp Biochem Physiol Part D Genomics Proteomics, 2008
Carboxylesterase 5 (CES5) (also called cauxin or CES7) is one of at least five mammalian CES gene families encoding enzymes of broad substrate specificity and catalysing hydrolytic and transesterification reactions.
Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor.
VandeBerg et al., San Antonio, United States. In Bmc Evol Biol, 2007
Phylogenetic analyses produced congruent phylogenetic trees depicting a rapid early diversification into at least five distinct CES gene family clusters: CES2, CES1, CES7, CES3, and CES6.
Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.
Review
Hosokawa, Chiba, Japan. In Molecules, 2007
It has been suggested that CESs can be classified into five major groups denominated CES1-CES5, according to the homology of the amino acid sequence, and the majority of CESs that have been identified belong to the CES1 or CES2 family.
Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus.
Shuman et al., New York City, United States. In Mol Cell Biol, 1998
We have characterized an essential Saccharomyces cerevisiae gene, CES5, that when present in high copy, suppresses the temperature-sensitive growth defect caused by the ceg1-25 mutation of the yeast mRNA guanylyltransferase (capping enzyme).
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