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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Collagen, type IV, alpha 3

CERT, GPBP, Goodpasture antigen-binding protein, ceramide transfer protein CERT
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, OSBP, Cho
Papers on CERT
Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools.
Ridgway et al., Halifax, Canada. In J Biol Chem, Feb 2016
25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the constitutive localization of OSBP at the ER/Golgi interface and PI-4P-dependent recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis.
Chlamydiae interaction with the endoplasmic reticulum: contact, function and consequences.
Derré, Charlottesville, United States. In Cell Microbiol, Jul 2015
These MCSs are constituted of a specific set of factors, including the C. trachomatis effector protein IncD and the host cell proteins CERT and VAPA/B.
Development of a CERT START Domain-Ceramide HTRF Binding Assay and Application to Pharmacological Studies and Screening.
Ausseil et al., Toulouse, France. In J Biomol Screen, Jul 2015
CERamide Transfer (CERT) protein is responsible for the nonvesicular trafficking of Cer to Golgi.
BF3-Mediated cis-Selective Cycloaddition of O-Silyloxime with Alkenes.
Tamura et al., Machida, Japan. In J Org Chem, Jun 2015
This cycloaddition was successfully applied to the synthesis of syn-HPA-12 known as an inhibitor of CERT that mediates the transport of ceramide.
The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers.
Génisson et al., Toulouse, France. In Bioorg Med Chem, Jun 2015
This preparative stereoselective synthesis allowed the unprecedented comparative evaluation of HPA-12 stereoisomers regarding their interaction with the CERT START domain.
Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins.
Overduin et al., Dresden, Germany. In J Mol Biol, Mar 2015
The determinants of this membrane sensing process are conserved across the CERT, OSBP and FAPP family.
Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.
Hanada et al., Tokyo, Japan. In Traffic, Feb 2015
These LTPs consist of ceramide transfer protein (CERT), four-phosphate adaptor protein 2 (FAPP2) and ceramide-1-phosphate transfer protein (CPTP), respectively.
New evidence for the role of ceramide in the development of hepatic insulin resistance.
Chabowski et al., Białystok, Poland. In Plos One, 2014
We observed a significant increase in the expression of fatty-acid transport protein (FATP2) and ceramide transfer protein (CERT) what is consistent with enhanced intracellular ceramide content.
A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells.
Radde et al., Stuttgart, Germany. In Bmc Syst Biol, 2014
This process is regulated by a complex molecular network including protein kinase D (PKD), which is directly involved in the fission of transport vesicles, and its interaction with the ceramide transfer protein CERT that transports ceramide from the endoplasmic reticulum to the TGN.
STIM1 Is a Novel Component of ER-Chlamydia trachomatis Inclusion Membrane Contact Sites.
Derré et al., New Haven, United States. In Plos One, 2014
These platforms contain the C. trachomatis inclusion membrane protein IncD, the mammalian ceramide transfer protein CERT and the ER resident proteins VAPA/B and were proposed to play a role in the non-vesicular trafficking of lipids to the inclusion.
Co-evolution of sphingomyelin and the ceramide transport protein CERT.
Hanada, Tokyo, Japan. In Biochim Biophys Acta, 2014
Human CERT is identical to the splicing variant of human Goodpasture antigen-binding protein (GPBP) annotated as an extracellular non-canonical serine/threonine protein kinase.
The complexity of sphingolipid biosynthesis in the endoplasmic reticulum.
Futerman et al., Israel. In Biochim Biophys Acta, 2013
We now discuss two enzymes in this pathway, namely serine palmitoyltransferase (SPT) and ceramide synthase (CerS), and one lipid transport protein, CERT.
Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network.
Hausser et al., Stuttgart, Germany. In Biochim Biophys Acta, 2012
CERT is at a convergence point of non-vesicular and vesicular transport processes and plays a central role within the PKD signaling network at the Golgi complex. (Review)
Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer.
Olayioye et al., Stuttgart, Germany. In Cancer Res, 2012
Loss of the ceramide transfer protein augments EGF receptor signaling in breast cancer.
Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.
Martinez-Martinez et al., Maastricht, Netherlands. In J Biol Chem, 2012
The START domain in GPBP is important for this interaction. SAP and GPBP form complexes in blood and partly colocalize in amyloid plaques from Alzheimer disease patients.
Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage.
Machamer et al., Baltimore, United States. In Biochem J, 2012
during cellular stress, disassembly of Golgi structure together with inactivation of CERT by caspases causes a reduction in ceramide trafficking and sphingomyelin synthesis, and could contribute to the cellular response to pro-apoptotic stress
Reminiscence of our research on membrane phospholipids in mammalian cells by using the novel technology.
Akamatsu, Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2011
Our second finding is "the ceramide-trafficking protein (CERT)" working as the specific transfer protein of ceramide from the ER to the Golgi apparatus, during the SM biosynthesis (by K. Hanada).
Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.
Engel et al., San Francisco, United States. In Plos Pathog, 2011
We hypothesize that sphingomyelin acquired by CERT-dependent transport of ceramide and subsequent conversion to SM is necessary for C. trachomatis replication whereas SM acquired by GBF1-dependent pathway is essential for inclusion growth and stability.
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Nicke et al., London, United Kingdom. In Cancer Cell, 2007
We also identify a ceramide transport protein, COL4A3BP or CERT, whose downregulation sensitizes cancer cells to multiple cytotoxic agents, potentiating endoplasmic reticulum stress.
Molecular machinery for non-vesicular trafficking of ceramide.
Nishijima et al., Tokyo, Japan. In Nature, 2004
CERT mediates the intracellular trafficking of ceramide in a non-vesicular manner
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