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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ceramide synthase 3

CerS3, LASS3, T3-L
Top mentioned proteins: LAG1, ACID, T1L, Cer, CAN
Papers on CerS3
Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors.
New
Sandhoff et al., Heidelberg, Germany. In Hum Mol Genet, Oct 2015
This pattern correlates with and depends on ceramide synthase 3 (CerS3) localization in both, pachytene spermatocytes until completion of meiosis and elongating spermatids.
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.
New
Voelkel-Johnson et al., İstanbul, Turkey. In J Biol Chem, Jun 2015
Similar to CerS6, overexpression of CerS3-5 resulted in an ∼2-fold increase in luciferase reporter gene activity.
Salacia reticulata (Kothala himbutu) revisited; a missed opportunity to treat diabetes and obesity?
Review
Medagama, Sri Lanka. In Nutr J, 2014
In 3 T3-L-1 adipocytes lipogenesis factors are down regulated and lipolysis factors are up regulated with Salacia reticulata treatment.
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
Willecke et al., Bonn, Germany. In Biochem J, 2014
Although CerS3 has been shown to fulfill an essential function during skin development, neither CerS6- nor CerS2-deficient mice show an obvious skin phenotype.
Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.
Hennies et al., Köln, Germany. In J Invest Dermatol, 2013
We demonstrate that the mutation inactivates ceramide synthase 3 (CerS3), which is synthesized in skin and testis, in an assay of N-acylation with C26-CoA, both in patient keratinocytes and using recombinant mutant proteins.
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.
Kihara et al., Sapporo, Japan. In Mol Cell Biol, 2013
Two ceramide synthases, CerS2 and CerS3, expressed in an epidermal layer-specific manner, regulate Elovl1 to produce acyl coenzyme As with different chain lengths.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Wang et al., Kunming, China. In Exp Ther Med, 2013
The expression levels of LASS1 and LASS3 mRNA were used as references.
Loss of ceramide synthase 3 causes lethal skin barrier disruption.
GeneRIF
Sandhoff et al., Heidelberg, Germany. In Hum Mol Genet, 2012
Deficiency of CerS3 in mice results in complete loss of ceramides with ultra-long-chain acyl moities (>/=C26), lack of continuous extracellular lipid lamellae and a non-functional cornified lipid envelope.
Very long chain sphingolipids: tissue expression, function and synthesis.
Review
Sandhoff, Heidelberg, Germany. In Febs Lett, 2010
This expression seems to depend on CerS3, one of six ceramide synthases.
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
Murabito et al., Pittsburgh, United States. In J Gerontol A Biol Sci Med Sci, 2010
Associations of interest in a homologue of the longevity assurance gene (LASS3) and PAPPA2 were not strengthened in the second stage.
Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies.
Merrill et al., Atlanta, United States. In J Lipid Res, 2010
Measuring the mRNA levels by quantitative RT-PCR and the amounts of the respective metabolites by LC-ESI/MS/MS, notable differences between R1 mESCs and EBs were: EBs have higher mRNAs for CerS1 and CerS3, which synthesize C18- and C>or=24-carbons dihydroceramides (DH)Cer, respectively; EBs have higher CerS2 (for C24:0- and C24:1-); and EBs have lower CerS5 + CerS6 (for C16-).
Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.
Flygare et al., Huddinge, Sweden. In Mol Cancer Res, 2009
The CB1-mediated induction of CerS3 and CerS6 mRNA was confirmed using Win-55,212-2.
Early deposition of n-3 fatty acids from tuna oil in lean and adipose tissue of fattening pigs is mainly permanent.
Kreuzer et al., Chiang Mai, Thailand. In J Anim Sci, 2009
The 4 treatments were 0% tuna oil in diet (T0; control), 1% of unrefined tuna oil in diet fed from 35 to 90 kg of BW (T1), and 3% of unrefined tuna oil in diet offered during the early (35 to 60 kg of BW; T3-E) or late stage of fattening (75 to 90 kg of BW; T3-L).
2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length.
Igarashi et al., Sapporo, Japan. In J Lipid Res, 2008
We reveal here that of the six, CerS3/LASS3 mRNA is the most predominantly expressed in keratinocytes.
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.
GeneRIF
Sandhoff et al., Heidelberg, Germany. In J Biol Chem, 2008
both glycans and the particular acyl chains of germinal sphingolipids are relevant for proper completion of meiosis
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.
GeneRIF
Igarashi et al., Sapporo, Japan. In Biochem J, 2006
The isolation and characterization of LASS3 and LASS3-long are reported.
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