Gangliosides have a functional role during rotavirus cell entry.
Ecatepec, Mexico. In J Virol, 2013
The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-α-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.
Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses.
Oxford, United Kingdom. In Glycobiology, 2005
An understanding of the molecular mechanism for the inhibition of the key enzyme in GSL biosynthesis, ceramide glucosyltransferase (CGT) by N-alkylated imino sugars, has also lead to compound design for improvements to inhibitory potency, bioavailability, enzyme selectivity, and biological safety.
[Functional glycoconjugates involved in cellular interaction].
Shizuoka, Japan. In Yakugaku Zasshi, 2003
We first examined the involvement of the complex sphingolipids in cell-substratum adhesion using GM-95, a mutant cell line deficient in glycosphingolipids (GSLs) due to the lack of ceramide glucosyltransferase activity.
Auckland, New Zealand. In Drugs, 2002
Miglustat is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside that occurs in patients with Gaucher's disease.