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Cerebellin 1 precursor

Cer, Cerberus, CER1, Cbln1, cerebellin
This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers on Cer
Introduction of the exogenous NADH coenzyme regeneration system and its influence on intracellular metabolic flux of Paenibacillus polymyxa.
Peng et al., Yancheng, China. In Bioresour Technol, Feb 2016
The titers of NADH, lactic acid, ethanol, NADH/NAD(+), and CO2 excretion rate (CER) of the recombinant strain increased considerably, while acetoin and formic acid decreased significantly.
The Effects of AS160 Modulation on Fatty Acid Transporters Expression and Lipid Profile in L6 Myotubes.
Chabowski et al., Poland. In Cell Physiol Biochem, Feb 2016
SFA, SA1P, CER, SFO and S1P, in the AS160 knockdown group.
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer.
Jiang et al., Qingdao, China. In Mol Med Report, Jan 2016
Treatment with FASN inhibitor Cer and FASN‑siRNA decreased the migratory capacity of bladder cancer cells and reduced the levels of p‑AKT as well as the expression of MMP‑9.
Targeted Lipidomic and Transcriptomic Analysis Identifies Dysregulated Renal Ceramide Metabolism in a Mouse Model of Diabetic Kidney Disease.
Pennathur et al., Ann Arbor, United States. In J Proteomics Bioinform, Oct 2015
Long-chain ceramides (C14:0, C16:0, C18:0, C20:0) and a glucosylceramide (Glu-Cer C18:0) were increased in diabetic mouse plasma, while long-chain (C14:0, C16:0, C18:0) and very-long-chain (C24:0, C24:1) ceramides and a glucosylceramide (Glu-Cer C16:0) were decreased in diabetic mouse kidney tissue.
Lipid-mediated muscle insulin resistance: different fat, different pathways?
Roden et al., Düsseldorf, Germany. In J Mol Med (berl), Aug 2015
Activation of Toll-like receptor 4 (TLR4) raises another lipid class, ceramides (CER), which induce pro-inflammatory pathways and lead to inhibition of Akt phosphorylation.
Toward hybrid force/position control for the Cerberus epicardial robot.
Riviere et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
To address this need we developed Cerberus, a minimally invasive parallel wire robot for cardiac interventions.
The Bone Morphogenetic Proteins and Their Antagonists.
Rider et al., London, United Kingdom. In Vitam Horm, 2014
One mechanism for enabling tight spatiotemporal control of their activities is through a number of antagonist proteins, including Noggin, Follistatin, Chordin, Twisted gastrulation (TSG), and the seven members of the Cerberus and Dan family.
Emerging small molecule drugs.
Staels et al., Lille, France. In Handb Exp Pharmacol, 2014
This chapter will highlight the emerging small molecules currently developed and tested in clinical trials to pharmacologically modulate HDL-C and functionality including new CETP inhibitors (anacetrapib, evacetrapib), novel PPAR agonists (K-877, CER-002, DSP-8658, INT131 and GFT505), LXR agonists (ATI-111, LXR-623, XL-652) and RVX-208.
Dynamic Control of Long-Range Genomic Interactions at the Immunoglobulin κ Light-Chain Locus.
Stadhouders et al., Oxford, United Kingdom. In Adv Immunol, 2014
Recent work has drawn attention to the intriguing role of the CTCF-associated regulatory elements Cer and Sis, which are located in the Vκ-Jκ intervening region and control Igκ locus contraction and Vκ repertoire diversity.
Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance.
Venerando et al., Milano, Italy. In Int J Mol Sci, 2013
In particular, in order to increase survival, cancer cells: (a) counteract the accumulation of ceramide that is endowed with pro-apoptotic potential and is induced by many drugs; (b) increase the synthesis of sphingosine-1-phosphate and glucosylceramide that are pro-survivals signals; (c) modify the synthesis and the metabolism of complex glycosphingolipids, particularly increasing the levels of modified species of gangliosides such as 9-O acetylated GD3 (αNeu5Ac(2-8)αNeu5Ac(2-3)βGal(1-4)βGlc(1-1)Cer) or N-glycolyl GM3 (αNeu5Ac (2-3)βGal(1-4)βGlc(1-1)Cer) and de-N-acetyl GM3 (NeuNH(2)βGal(1-4)βGlc(1-1)Cer) endowed with anti-apoptotic roles and of globoside Gb3 related to a higher expression of the multidrug resistance gene MDR1.
3D reconstruction of the source and scale of buried young flood channels on Mars.
Phillips et al., Washington, D.C., United States. In Science, 2013
Our work shows that Cerberus Fossae provided the waters that carved Marte Vallis, and it extended an additional 180 kilometers to the east before the emplacement of the younger lava flows.
Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women.
Kollia et al., Athens, Greece. In Calcif Tissue Int, 2012
CER1 gene variations play a significant role in determining BMD and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk
Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
Mishina et al., Tokyo, Japan. In J Neurochem, 2012
GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2
Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice.
Morgan et al., Memphis, United States. In J Neurochem, 2012
Cbln1 and Cbln2 are co-expressed in the endolysosomal compartment of the thalamic neurons responsible for the synaptic alterations in striatum of Cbln1-null mice.
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions.
Yuzaki et al., Tokyo, Japan. In Eur J Neurosci, 2011
Data show that Cbln1 and Cbln2, but not Cbln4, specifically bind to neurexin 1alpha and -beta and induce synaptogenesis in cerebellar, hippocampal and cortical neurons in vitro.
Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.
Mishina et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4.
Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.
Mishina et al., Tokyo, Japan. In Cell, 2010
Results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1.
Athabasca Valles, Mars: a lava-draped channel system.
Russell et al., Flagstaff, United States. In Science, 2007
Purported ice features in Athabasca Valles and its distal basin, Cerberus Palus, are actually composed of this lava.
Evidence from the Mars Express High Resolution Stereo Camera for a frozen sea close to Mars' equator.
HRSC Co-Investigator Team et al., Milton Keynes, United Kingdom. In Nature, 2005
It is thought that the Cerberus Fossae fissures on Mars were the source of both lava and water floods two to ten million years ago.
Drosophila long-term memory formation involves regulation of cathepsin activity.
Preat et al., Gif-sur-Yvette, France. In Nature, 2004
Here we describe a Drosophila melanogaster mutant, crammer (cer), which shows a specific LTM defect.
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