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Centrin, EF-hand protein, 1

Centrin, caltractin, centrin-2
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: XPC, CAN, ACID, V1a, fibrillin-1
Papers using Centrin antibodies
Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors
Gleeson Joseph G et al., In Nature genetics, 2002
... Transgenic mouse line with green-fluorescent protein-labeled Centrin 2 allows visualization of the centrosome in living cellsTransgenic Res ...
Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells
Sluder Greenfield et al., In The Journal of Cell Biology, 2001
... Centrin-1/GFP in pEGFP-N1 vector (Piel et al., 2000) was transfected into telomerase-immortalized normal human cells (hTERT-RPE1; CLONTECH Laboratories, Inc.), and stable ...
Cytoplasmic assembly of Mts in cultured cells
Bornens Michel et al., In The Journal of Cell Biology, 1996
... Centrin cDNA was sub-cloned in the pEGFP-N1 vector (Clontech) and cells were transformed ...
Papers on Centrin
New insights into the interaction of centrin with Sfi1.
Assairi et al., Orsay, France. In Biochim Biophys Acta, Feb 2016
To investigate the parameters involved in centrin binding, we purified a ScSfi1 domain containing 6 repeats complexed with either yeast centrin Cdc31 or human centrin 1.
Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters.
Nakhasi et al., Belo Horizonte, Brazil. In Plos Negl Trop Dis, Jan 2016
We have previously reported a protective response in mice, hamsters and dogs with Leishmania donovani centrin gene knock-out parasites (LdCen-/-), a live attenuated parasite with a cell division specific centrin1 gene deletion.
Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function.
Fisk et al., Liverpool, United Kingdom. In Mol Biol Cell, Dec 2015
We previously identified centrin 2 and centrin 3 (Cetn2 and Cetn3) as substrates of the protein kinase Mps1.
Molecular aspects of calcium signalling at the crossroads of unikont and bikont eukaryote evolution--the ciliated protozoan Paramecium in focus.
Plattner, Konstanz, Germany. In Cell Calcium, Mar 2015
Centrin inactivates Ca(2+) signals after stimulation by its high capacity/low affinity binding sites, whereas its high affinity sites regulate some other functions.
Centrin: another target of monastrol, an inhibitor of mitotic spindle.
Yang et al., Taiyuan, China. In Spectrochim Acta A Mol Biomol Spectrosc, Mar 2015
Centrin, a ubiquitous protein associated with centrosome, plays a critical role in centrosome duplication.
Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.
Sugasawa et al., Kōbe, Japan. In Nucleic Acids Res, Mar 2015
Furthermore, XPC competitively suppressed ubiquitination of DDB2 in vitro, and this effect was significantly promoted by centrin-2, which augments the DNA damage-recognition activity of XPC.
Lineage specificity of primary cilia in the mouse embryo.
Anderson et al., New York City, United States. In Nat Cell Biol, Feb 2015
Here we define when and where primary cilia appear in the mouse embryo using a transgenic line that expresses ARL13B-mCherry in cilia and Centrin 2-GFP in centrosomes.
A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.
Qian et al., Beijing, China. In Mol Oncol, Feb 2015
Acentrosomal spindle poles, which do not contain the bona-fide centrosome components γ-tubulin and centrin-2, were found to contribute to the spindle multipolarity induced by mdivi-1.
Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.
Klymkowsky et al., Boulder, United States. In Sci Rep, 2014
Two distinct Cetn subtypes, Cetn2-like and Cetn3-like, have been recognized and implicated in a range of cellular processes.
A novel role of centrin in flagellar motility: stabilizing an inner-arm dynein motor in the flagellar axoneme.
Li, Houston, United States. In Microb Cell, 2014
UNASSIGNED: Centrin is an evolutionarily conserved EF-hand calcium-binding protein found in the centriole of animals and the basal body of flagellated organisms.
Centrin3 in trypanosomes maintains the stability of a flagellar inner-arm dynein for cell motility.
Li et al., Houston, United States. In Nat Commun, 2013
Centrin is a conserved component of centrioles in animals and basal bodies in flagellated organisms.
Influence of centrin 2 on the interaction of nucleotide excision repair factors with damaged DNA.
Lavrik et al., Novosibirsk, Russia. In Biochemistry (mosc), 2012
Cen2 influences the binding of RPA and XPA with damaged DNA.
Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells.
Angulo et al., Fontenay-aux-Roses, France. In Dna Repair (amst), 2011
xeroderma pigmentosum complementation group C expression correlates with a decreased amount of CENTRIN 2 transcript and protein
Open, repair and close again: chromatin dynamics and the response to UV-induced DNA damage.
Zurita et al., Ecatepec, Mexico. In Dna Repair (amst), 2011
The ubiquitinated nucleosome facilitates the recruitment of ATP-dependent chromatin-remodeling factors and the XPC-HR23B-Centrin 2 complex to the target region.
CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.
Ducommun et al., Brisbane, Australia. In Biol Cell, 2011
CDC25B forms a close association with Ctn-2 proteins at the centrosome.
Mps1 phosphorylation sites regulate the function of centrin 2 in centriole assembly.
Fisk et al., Columbus, United States. In Mol Biol Cell, 2010
Mps1-dependent phosphorylation of Cetn2 stimulates the canonical centriole assembly pathway.
Control of centrin stability by Aurora A.
Lingle et al., Rochester, United States. In Plos One, 2010
The stability of centrin is regulated in part by Aurora A.
Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein.
Naegeli et al., Zürich, Switzerland. In Mutat Res, 2010
It remains to be elucidated how accessory factors like Rad23B, centrin-2 or the UV-damaged DNA-binding complex contribute to this dynamic two-stage quality control process.
Calcium regulation and signaling in apicomplexan parasites.
Sibley et al., Saint Louis, United States. In Subcell Biochem, 2007
Downstream responses are controlled by a family of EF-hand containing calcium binding proteins including calmodulin, and an array of centrin and caltractin-like genes.
Protein networks and complexes in photoreceptor cilia.
Wolfrum et al., Nijmegen, Netherlands. In Subcell Biochem, 2006
Centrin-G-protein complexes may regulate the light driven translocation of the visual G-protein transducin through the connecting cilium.
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