gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Centromere protein F, 350/400kDa

CENPF, Mitosin, LEK1, centromere protein F, AH antigen, HCP-1
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, OUT, CAN, SET, AGE
Papers using CENPF antibodies
The complexities of proliferating cell nuclear antigen
Supplier
Torp Sverre H et al., In Diagnostic Pathology, 1991
... MitosinNovus Biologicals, LTD, Cambridge, UK ...
Papers on CENPF
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
New
Ellis et al., Houston, United States. In Stem Cells Transl Med, Feb 2016
We treated established CRC cell lines and a newly established human CRC cell line HCP-1 with ADAM17-specific small interfering RNA (siRNA) or the synthetic peptide inhibitor TAPI-2.
Mitosin and pHH3 predict poorer survival in astrocytomas WHO grades II and III.
New
Torp et al., Trondheim, Norway. In J Clin Pathol, Jan 2016
The objective of this study was to evaluate the diagnostic and prognostic value of the proliferation markers mitosin and phosphohistone H3 (pHH3) in infiltrative astrocytomas WHO grades II and III and compare the findings with mitotic count and Ki-67/MiB-1 immunostaining.
Functional analysis of the nasopharyngeal carcinoma primary tumor‑associated gene interaction network.
New
Xia et al., Jinan, China. In Mol Med Report, Oct 2015
Furthermore, PDZ binding kinase (PBK), centromere protein F (CENPF), actin‑binding protein anillin (ANLN), exonuclease 1 (EXO1) and chromosome 15 open reading frame 42 (C15ORF42) were included in the obtained network module, which was closely associated with the cell cycle and nucleic acid metabolic process GO functions.
Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.
New
Califano et al., New York City, United States. In Cell Rep, Oct 2015
Network-based analysis of expression profiles from in vivo treatment of GEM models identified drugs and drug combinations that inhibit the activity of FOXM1 and CENPF, which are master regulators of prostate cancer malignancy.
MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer.
New
Seki et al., Chiba, Japan. In Int J Urol, Sep 2015
Our data showed that the centromere protein F gene was overexpressed in prostate cancer clinical specimens and was a direct target of microRNA-205 regulation.
TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma.
New
Ng et al., Hong Kong, Hong Kong. In Front Med, Sep 2015
Top-listing upregulated (CENPF and FOXM1) and downregulated (CLEC4G, CRHBP, and CLEC1B) genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs.
Mitosin and pHH3 predict poorer survival in astrocytomas WHO grades II and III.
New
Torp et al., Trondheim, Norway. In J Neurol Neurosurg Psychiatry, Sep 2015
The objective of this study was to evaluate the diagnostic and prognostic value of the proliferation markers mitosin and phosphohistone H3 (pHH3) in infiltrative astrocytomas WHO grades II and III and compare the findings with mitotic count and Ki-67/MiB-1 immunostaining.
Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules.
New
McIntosh et al., Moscow, Russia. In J Cell Biol, Jul 2015
Centromere protein F (CENP-F) has been shown to include two MT-binding domains, so it may participate in this key mitotic process.
Kinetochore components are required for central spindle assembly.
New
Impact
Dumont et al., Paris, France. In Nat Cell Biol, May 2015
Specifically, central spindle microtubule assembly is dependent on kinetochore recruitment of the scaffold protein KNL-1, as well as downstream partners BUB-1, HCP-1/2(CENP-F) and CLS-2(CLASP); and is negatively regulated by kinetochore-associated protein phosphatase 1 activity.
An Analysis of Immunoreactive Signatures in Early Stage Hepatocellular Carcinoma.
New
Huang et al., Beijing, China. In Ebiomedicine, May 2015
Among them, CENPF, HSP60 and IMP-2 showed AUC (area under the curve) values of 0.826, 0.764 and 0.796 respectively for early HCC.
Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.
Impact
Abate-Shen et al., New York City, United States. In Cancer Cell, 2014
Cross-species computational analysis of these interactomes has identified FOXM1 and CENPF as synergistic master regulators of prostate cancer malignancy.
Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.
GeneRIF
Lanzetti et al., Torino, Italy. In Proc Natl Acad Sci U S A, 2011
Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores.
Centromere protein F and survivin are associated with high risk and a poor prognosis in colorectal gastrointestinal stromal tumours.
GeneRIF
Fei et al., Hangzhou, China. In J Clin Pathol, 2011
Centromere protein F and survivin are malignant behaviour markers for colorectal gastrointestinal stromal tumours.
Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase.
GeneRIF
Zhu et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2010
Cenp-F plays a role in organization of interphase chromatin through association and possibly regulation of DNA-PK.
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.
GeneRIF
Robertson et al., Philadelphia, United States. In J Virol, 2010
the interaction between LANA and the kinetochore proteins CENP-F and Bub1 is important for KSHV genome tethering and its segregation to new daughter cells
Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma.
GeneRIF
Zeng et al., China. In Mol Cancer, 2009
Data suggest that CENP-F protein is a valuable marker of nasopharyngeal carcinoma progression, and CENP-F expression is associated with poor overall survival of patients.
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
Impact
Hildebrandt et al., Ann Arbor, United States. In Nat Genet, 2006
It encodes a protein with several domains also present in CENPF, a protein involved in chromosome segregation.
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.
Review
Beese et al., Durham, United States. In J Lipid Res, 2006
Prenylated proteins include members of the Ras, Rab, and Rho families, lamins, CENPE and CENPF, and the gamma subunit of many small heterotrimeric G proteins.
Mitosin/CENP-F in mitosis, transcriptional control, and differentiation.
Review
GeneRIF
Zhu et al., Shanghai, China. In J Biomed Sci, 2006
REVIEW: involvement in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation.
Rb and LEK1: a "pas de deux" in cardiogenesis.
Review
Pucéat, Montpellier, France. In Cell Cycle, 2005
Recently, using Rb-/- and LEK1-downregulated ES cells, we described a novel BMP-independent cardiogenic pathway implicating both Rb and LEK1, a mammalian homolog of the chicken cardiomyogenic factor 1(CMF1).
share on facebooktweetadd +1mail to friends