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Centromere protein H

CENP-H, NNFI, Centromere protein H
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gli, CENP-C, Mis6, Histone, CFI
Papers using CENP-H antibodies
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis
Supplier
Dasso Mary et al., In The Journal of Cell Biology, 2007
... CENP-H antibody was purchased from Bethyl Laboratories, Inc ...
Papers on CENP-H
The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.
New
Cheeseman et al., Cambridge, United States. In Mol Cell, Jan 2016
We demonstrate that the CENP-L-N complex plays a crucial role at the core of this assembly through interactions with CENP-C and CENP-H-I-K-M.
Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis.
New
Yao et al., Hefei, China. In J Biol Chem, Dec 2015
Although kinetochore protein CENP-H serves as a molecular control of kinetochore-microtubule dynamics, the mechanistic link between CENP-H and kinetochore microtubules (kMT) has remained less characterized.
Dynamic changes in CCAN organization through CENP-C during cell-cycle progression.
New
Fukagawa et al., Mishima, Japan. In Mol Biol Cell, Dec 2015
To address this, we analyzed the relationship of centromeric protein (CENP)-C with the CENP-H complex during progression of the cell cycle.
Upregulation of centromere protein H is associated with progression of renal cell carcinoma.
New
Wu et al., Guangzhou, China. In J Mol Histol, Oct 2015
Centromere protein H (CENPH), one of the essential component of active kinetochore, plays an important role in carcinogenesis of many cancer types.
Self-Determination and Physical Exercise Adherence in the Contexts of Fitness Academies and Personal Training.
New
Moutão et al., Vila Real, Portugal. In J Hum Kinet, Jul 2015
NNFI = .906;
Social media as social capital of LGB individuals in Hong Kong: its relations with group membership, stigma, and mental well-being.
New
Pang et al., Hong Kong, Hong Kong. In Am J Community Psychol, Mar 2015
Based on a sample of 233 Chinese LGB individuals in Hong Kong, structural equation modeling showed evidence for our hypotheses, χ(df=62)(2)= 88.20, GFI = 0.95, CFI = 0.98, NNFI = 0.98, SRMR = 0.07, RMSEA = 0.04.
Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
New
Yu et al., Dallas, United States. In J Cell Biol, Feb 2015
In another, CENP-T contributes to KMN attachment in a CENP-H-I-K-dependent manner.
Factorial Structure and Measurement Invariance of the PANAS in Spanish Older Adults.
Urchaga et al., Salamanca, Spain. In Span J Psychol, 2014
NNFI = .97)
Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.
GeneRIF
Zhang et al., Guangzhou, China. In Febs J, 2012
Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas.
The ABCs of CENPs.
Review
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase.
Review
Dasso et al., Bethesda, United States. In Cell Cycle, 2010
This gross mislocalization of IKPs is due to proteolytic degradation of CENP-I and CENP-H via the SUMO targeted Ubiquitin Ligase (STUbL) pathway.
Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.
Impact
Meraldi et al., Zürich, Switzerland. In Nat Cell Biol, 2010
Here we show that centromere protein (CENP)-H, a subunit of the CENP-A nucleosome-associated and CENP-A distal complexes (CENP-A NAC/CAD), is essential for this coordination, because kinetochores lacking CENP-H establish bioriented attachments but fail to generate regular oscillations, as a result of an uncontrolled rate of microtubule plus-end turnover.
CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.
GeneRIF
Fukagawa et al., Hachiōji, Japan. In Mol Biol Cell, 2009
CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1.
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Impact
Straight et al., Palo Alto, United States. In Nat Cell Biol, 2009
Mutations in CENP-N that reduced its affinity for CENP-A nucleosomes caused defects in CENP-N localization and had dominant effects on the recruitment of CENP-H, CENP-I and CENP-K to centromeres.
TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression.
GeneRIF
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2009
TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H.
Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival.
GeneRIF
Song et al., Guangzhou, China. In Cancer, 2009
expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer
Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression.
GeneRIF
Li et al., Guangzhou, China. In J Exp Clin Cancer Res, 2008
Upregulation of CENP-H in tongue cancer is associated with disease progression.
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
Impact
GeneRIF
Fukagawa et al., Mishima, Japan. In Nat Cell Biol, 2006
The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres.
The human CENP-A centromeric nucleosome-associated complex.
Impact
Cleveland et al., San Diego, United States. In Nat Cell Biol, 2006
Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along with CENP-U(50), CENP-C and CENP-H.
Building the centromere: from foundation proteins to 3D organization.
Review
Choo et al., Melbourne, Australia. In Trends Cell Biol, 2004
CENP-A, Mis12, CENP-C, CENP-H and CENP-I localize to a core domain of centromeric chromatin.
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