What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).
London, United Kingdom. In Mol Cell Probes, Oct 2015
The functions of proteins such as WDR62, CASC5, PHC1, CDK6, CENP-E, CENP-F, CEP63, ZNF335, PLK4 and TUBGPC, have been added to the complex network of critical cellular processes known to be involved in brain growth and size.
Mitosis as an anti-cancer drug target.
Turku, Finland. In Chromosoma, 2013
In order to overcome these issues, a great deal of effort has been spent exploring novel mitotic targets including Polo-like kinase 1, Aurora kinases, Mps1, Cenp-E and KSP/Eg5.
CENP-E hangs on at dynamic microtubule ends.
Minneapolis, United States. In Nat Cell Biol, 2013
CENP-E, a kinesin-7 family member, is now shown to have a role in associating kinetochores with dynamic microtubule plus ends.
Emerging mitotic inhibitors for non-small cell carcinoma.
Napoli, Italy. In Expert Opin Emerg Drugs, 2013
Furthermore, the identification of novel mitotic drug targets other than microtubules has gained recently much attention, such as aurora kinases, Polo-like kinase1 (PLK1), kinesin spindle protein (KSP), and centromeric protein E (CENPE).
Kinesins and cancer.
Glasgow, United Kingdom. In Nat Rev Cancer, 2012
Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs.