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Centromere protein E, 312kDa

Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bub1, CAN, Mad2, CENP-C, Aurora
Papers using CENP-E antibodies
Kinetochore microtubule dynamics and the metaphase–anaphase transition
Yen T.J. et al., In The Journal of Cell Biology, 1994
... A 1.3-kb Dra I CENP-E cDNA fragment was subcloned into pMAL expression vector (New England Biolabs ...
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1991
... Astrin, separase, and CENP-E were targeted with 5′-TCCCGACAACTCACAGAGAAA-3′, 5′-AAGCTTGTGATGCCATCCTGA-3′, and 5′-ACTCTTACTGCTCTCCAGTTT-3′ (QIAGEN), respectively ...
Papers on CENP-E
New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations.
Guillou et al., Gif-sur-Yvette, France. In Bioorg Med Chem, Jan 2016
The two most advanced kinesin targets are Eg5 and CENP-E with inhibitors in clinical trials.
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
Earnshaw et al., Suita, Japan. In J Cell Biol, Jan 2016
Ndc80 associated with CENP-T interacts with a cohort of Rod, zw10, and zwilch (RZZ)-interacting proteins that includes Spindly, Mad1, and CENP-E.
Expression data of HeLa cells treated with CENP-E siRNA or Eg5 siRNA in the presence of BubR1 siRNA.
Ohashi et al., Fujisawa, Japan. In Genom Data, Dec 2015
We investigated the postmitotic effects of different mitotic aberrations (Ohashi et al. [1]), misaligned chromosomes produced by CENP-E siRNA (siCENP-E), and monopolar spindles resulting from Eg5 siRNA (siEg5) (Miki et al. [2]).
Low expression of spindle checkpoint protein, Cenp-E, causes numerical chromosomal abnormalities in HepG-2 human hepatoma cells.
Liu et al., Hengyang, China. In Oncol Lett, Nov 2015
UNASSIGNED: The aim of the present study was to investigate the expression, localization and role of centromere-associated protein E (Cenp-E) in hepatoma cells.
What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).
Kaindl et al., London, United Kingdom. In Mol Cell Probes, Oct 2015
The functions of proteins such as WDR62, CASC5, PHC1, CDK6, CENP-E, CENP-F, CEP63, ZNF335, PLK4 and TUBGPC, have been added to the complex network of critical cellular processes known to be involved in brain growth and size.
Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.
Watanabe et al., Tokyo, Japan. In Nat Cell Biol, Sep 2015
Similarly, human Mad1 recruits another kinetochore motor CENP-E, revealing that Mad1 is the conserved dual-function protein acting in SAC activation and chromosome gliding.
Mitosis. Microtubule detyrosination guides chromosomes during mitosis.
Maiato et al., Porto, Portugal. In Science, Jun 2015
Centromere-associated protein E (CENP-E)/Kinesin-7 is a microtubule plus-end-directed kinetochore motor required for congression of pole-proximal chromosomes.
A Novel Time-Dependent CENP-E Inhibitor with Potent Antitumor Activity.
Okaniwa et al., Fujisawa, Japan. In Plos One, 2014
UNASSIGNED: Centromere-associated protein E (CENP-E) regulates both chromosome congression and the spindle assembly checkpoint (SAC) during mitosis.
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.
Maiato et al., Porto, Portugal. In Nat Cell Biol, 2014
These proteins include the minus-end-directed kinetochore motor dynein, and the plus-end-directed motors CENP-E at kinetochores and chromokinesins on chromosome arms.
The enigmatic ERH protein: its role in cell cycle, RNA splicing and cancer.
Luo et al., In Protein Cell, 2013
We recently showed that ERH binds to the Sm complex and is required for the mRNA splicing of the mitotic motor protein CENP-E.
Mitosis as an anti-cancer drug target.
Kallio et al., Turku, Finland. In Chromosoma, 2013
In order to overcome these issues, a great deal of effort has been spent exploring novel mitotic targets including Polo-like kinase 1, Aurora kinases, Mps1, Cenp-E and KSP/Eg5.
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.
Grishchuk et al., Philadelphia, United States. In Nat Cell Biol, 2013
During vertebrate mitosis, the centromere-associated kinesin CENP-E (centromere protein E) transports misaligned chromosomes to the plus ends of spindle microtubules.
CENP-E hangs on at dynamic microtubule ends.
Gardner, Minneapolis, United States. In Nat Cell Biol, 2013
CENP-E, a kinesin-7 family member, is now shown to have a role in associating kinetochores with dynamic microtubule plus ends.
Emerging mitotic inhibitors for non-small cell carcinoma.
Gridelli et al., Napoli, Italy. In Expert Opin Emerg Drugs, 2013
Furthermore, the identification of novel mitotic drug targets other than microtubules has gained recently much attention, such as aurora kinases, Polo-like kinase1 (PLK1), kinesin spindle protein (KSP), and centromeric protein E (CENPE).
Kinesins and cancer.
Kozielski et al., Glasgow, United Kingdom. In Nat Rev Cancer, 2012
Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs.
CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.
Mao et al., New York City, United States. In J Cell Biol, 2012
It was shown that the state of CENP-E-dependent BubR1 autophosphorylation in response to spindle microtubule capture by CENP-E is important for kinetochore function in achieving accurate chromosome segregation.
Microtubule capture by mitotic kinesin centromere protein E (CENP-E).
Gilbert et al., Troy, United States. In J Biol Chem, 2012
the unusually slow CENP-E microtubule association step favors CENP-E binding of stable microtubules over dynamic ones, a mechanism that would bias CENP-E binding to kinetochore fibers.
Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes.
Homer et al., London, United Kingdom. In Development, 2012
CENP-E stabilises BubR1, thereby impacting meiosis I progression, and mediates bi-orientation by promoting kinetochore reorientation and preventing chromosomal drift towards the poles.
CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
Maiato et al., Porto, Portugal. In Nat Cell Biol, 2012
Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells.
CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis.
Yao et al., Hefei, China. In J Biol Chem, 2012
SKAP cooperates with CENP-E to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation.
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