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Centromere protein C 1

CENP-C, centromere protein C
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Gli, Histone, CENP-B, CAN, CENP-E
Papers using CENP-C antibodies
T-Coffee: A novel method for fast and accurate multiple sequence alignment.
Imhof Axel, In PLoS ONE, 1999
... To build N-GFP::HA::CENPC and C-GFP::HA::CENPC expression plasmids, the Enhanced-GFP N-terminal (N-GFP, aa 1/157) and the C-Terminal (C-GFP, aa 158/239) halves were generated by PCR using as template the pEGFP-C3 vector (Clontech, GenBank Acc.: U57607) and ...
Papers on CENP-C
Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.
Earnshaw et al., Suita, Japan. In J Cell Biol, Jan 2016
Ndc80 associated with CENP-C forms the KMN (Knl1, Mis12, Ndc80) network and may be the microtubule-binding "workhorse" of the kinetochore.
The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.
Cheeseman et al., Cambridge, United States. In Mol Cell, Jan 2016
We demonstrate that the CENP-L-N complex plays a crucial role at the core of this assembly through interactions with CENP-C and CENP-H-I-K-M.
CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
Masumoto et al., Nagoya, Japan. In J Cell Sci, Jan 2016
We showed that these components work by recruiting CENP-C and subsequently recruiting M18BP1.
Dynamic changes in CCAN organization through CENP-C during cell-cycle progression.
Fukagawa et al., Mishima, Japan. In Mol Biol Cell, Dec 2015
We find that the middle portion of chicken CENP-C (CENP-C(166-324)) is sufficient for centromere localization during interphase, potentially through association with the CENP-L-N complex.
Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.
Funabiki et al., In J Cell Biol, Oct 2015
Both outer kinetochore proteins (Bub1, BubR1, Mad1, and CENP-E) and the inner kinetochore component CENP-C are integral components of the expandable module, whose assembly depends on multiple mitotic kinases (Aurora B, Mps1, and Plx1) and is suppressed by protein phosphatase 1.
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
Black et al., Philadelphia, United States. In Science, Jun 2015
CENP-C binds to CENP-A nucleosomes and is a prime candidate to stabilize centromeric chromatin.
A two-step mechanism for epigenetic specification of centromere identity and function.
Cleveland et al., San Diego, United States. In Nat Cell Biol, 2013
Subsequently, nucleation of kinetochore assembly onto CATD-containing chromatin is shown to require either the amino- or carboxy-terminal tail of CENP-A for recruitment of inner kinetochore proteins, including stabilizing CENP-B binding to human centromeres or direct recruitment of CENP-C, respectively.
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.
Bai et al., Bethesda, United States. In Science, 2013
Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centromere protein C (CENP-C).
The ABCs of CENPs.
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes.
Cheeseman et al., Cambridge, United States. In Cell, 2011
Here, we demonstrate that two constitutive DNA-binding kinetochore components, CENP-C and CENP-T, function to direct kinetochore formation.
CENP-C is a structural platform for kinetochore assembly.
Glover et al., Cambridge, United Kingdom. In Curr Biol, 2011
The N-terminal part of Drosophila CENP-C is sufficient to recruit core kinetochore components and acts as the principal linkage between centromere and kinetochore during mitosis.
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
Musacchio et al., Milano, Italy. In Curr Biol, 2011
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.
Harrison et al., Boston, United States. In Cell, 2010
Csm1 presents a conserved hydrophobic surface patch that binds two kinetochore proteins: Dsn1, a subunit of the outer-kinetochore MIND/Mis12 complex, and Mif2/CENP-C.
DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.
Robertson et al., Gainesville, United States. In Hum Mol Genet, 2009
DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere.
CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.
Watanabe et al., Tokyo, Japan. In Dev Cell, 2009
CENP-C serves as a scaffold for the specific recruitment of essential kinetochore proteins
The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.
Della Valle et al., Bologna, Italy. In Plos One, 2008
C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation
PTEN mutation: many birds with one stone in tumorigenesis.
Shen et al., Huaihua, China. In Anticancer Res, 2008
PTEN also associates with the centromeric protein CENP-C to maintain centromere integrity and suppresses chromosomal instability from DNA double-strand breaks (DSBs) through transcriptional regulation of Rad51 (radiosensitive yeast mutant 51).
Centromeric chromatin: what makes it unique?
Dalal et al., Seattle, United States. In Curr Opin Genet Dev, 2005
Other studies have taken a comparative approach focusing on centromere-specific proteins, of which mammalian CENP-A and CENP-C are the prototypes.
Building the centromere: from foundation proteins to 3D organization.
Choo et al., Melbourne, Australia. In Trends Cell Biol, 2004
CENP-A, Mis12, CENP-C, CENP-H and CENP-I localize to a core domain of centromeric chromatin.
An apparently acentric marker chromosome originating from 9p with a functional centromere without detectable alpha and beta satellite sequences.
Palmer et al., Indianapolis, United States. In Am J Med Genet, 1997
Studies using centromere proteins (CENP-B, CENP-C, and CENP-E) were performed and demonstrated the presence of centromere proteins.
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