Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
San Francisco, United States. In J Med Chem, Jan 2016
More recently, non-BET bromodomain inhibitors that are potent and selective have been disclosed for ATAD2, CBP, BRD7/9, BRPF, BRPF/TRIM24, CECR2, SMARCA4, and BAZ2A/B.
[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.
Oxford, United Kingdom. In J Med Chem, 2014
Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside the BET family such as BRD9, CECR2, and CREBBP.