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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cat eye syndrome chromosome region, candidate 2

CECR2, cat eye syndrome chromosome region candidate 2
Top mentioned proteins: TUBE, catalase, SWI, Histone, BRD9
Papers on CECR2
Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
New
Magnuson et al., San Francisco, United States. In J Med Chem, Jan 2016
More recently, non-BET bromodomain inhibitors that are potent and selective have been disclosed for ATAD2, CBP, BRD7/9, BRPF, BRPF/TRIM24, CECR2, SMARCA4, and BAZ2A/B.
A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
New
Cochran et al., San Francisco, United States. In Structure, Nov 2015
Profiling the nearly complete human bromodomain family revealed that while most human bromodomains bind only the shorter acetyl and propionyl marks, the bromodomains of BRD9, CECR2, and the second bromodomain of TAF1 also recognize the longer butyryl mark.
Integrative DNA methylation and gene expression analysis identifies discoidin domain receptor 1 association with idiopathic nonobstructive azoospermia.
Lamb et al., Houston, United States. In Fertil Steril, 2014
From the top 10 hypermethylated genes, six genes (MRI1, DCAF12L1, TMEM95, CECR2, DDR1, and NPHS2) were selected for validation because they were shown to be expressed in the testis.
[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.
Brennan et al., Oxford, United Kingdom. In J Med Chem, 2014
Commercially sourced and de novo synthesized substituted [1,2,4]triazolo[4,3-a]phthalazines are potent inhibitors of both the BET bromodomains such as BRD4 as well as bromodomains outside the BET family such as BRD9, CECR2, and CREBBP.
A 600 kb triplication in the cat eye syndrome critical region causes anorectal, renal and preauricular anomalies in a three-generation family.
van Zutven et al., Rotterdam, Netherlands. In Eur J Hum Genet, 2012
This finding suggests that amplification of the genes CECR2, SLC25A18 and ATP6V1E1, mapping within the critical region for CES, may be responsible for anorectal, renal and preauricular anomalies in patients with CES.
A de novo sSMC(22) Characterized by High-Resolution Arrays in a Girl with Cat-Eye Syndrome without Coloboma.
Ortiz-López et al., Monterrey, Mexico. In Mol Syndromol, 2012
Conversely, even though the amplification included the CECR2 gene, a major candidate for eye features, there was no coloboma in the patient.
Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein.
Kwon et al., Seoul, South Korea. In Mol Cells, 2012
We identified the BRD of cat eye syndrome chromosome region candidate 2 (Cecr2), which recently was shown to form a novel chromatin remodeling complex with unknown cellular functions, as having a strong γ-H2AX inhibition activity.
CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.
GeneRIF
McDermid et al., Edmonton, Canada. In J Mol Biol, 2012
The results demonstrated a novel role of CECR2-containing complexes in spermatogenesis and showed that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis.
Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.
GeneRIF
McDermid et al., Edmonton, Canada. In Physiol Genomics, 2012
Strain-specific modifier genes of Cecr2-associated exencephaly in mice.
The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications.
Iyer et al., Bethesda, United States. In Cell Cycle, 2012
In other eukaryotic chromatin proteins, this predicted DNA-binding domain is fused to a region with three conserved motifs that are also found in diverse eukaryotic chromatin proteins, such as the animal BAZ/WAL proteins, plant HB1 and MBD9, yeast Itc1p and Ioc3, RSF1, CECR2 and NURF1.
Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.
GeneRIF
McDermid et al., Edmonton, Canada. In Dev Dyn, 2011
Data show that two independent mutations of Cecr2 are also associated with specific inner ear defects.
Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors.
GeneRIF
McDermid et al., Edmonton, Canada. In Birth Defects Res A Clin Mol Teratol, 2010
A novel Cecr2 null allele (Cecr2(tm1.1Hemc)) had a stronger penetrance of exencephaly than Cecr2(Gt45Bic) in both BALB/c and FVB/N strains, in addition to midline facial clefts and forebrain encephalocele in the FVB/N strain.
Molecular cloning of chicken Cecr2 and its expression during chicken embryo development.
Brand-Saberi et al., Freiburg, Germany. In Int J Dev Biol, 2009
Cecr2 is a transcription factor involved in neurulation and chromatin remodeling.
Modifier locus for exencephaly in Cecr2 mutant mice is syntenic to the 10q25.3 region associated with neural tube defects in humans.
McDermid et al., Edmonton, Canada. In Physiol Genomics, 2007
We previously reported that a homozygous Cecr2 mutation on a BALB/c background causes exencephaly at a frequency of 74% compared with 0% on an FVB/N background.
Mutation analysis of Drosophila dikar/CG32394, homologue of the chromatin-remodelling gene CECR2.
McDermid et al., Edmonton, Canada. In Genome, 2007
The mammalian CECR2 protein contains a highly conserved bromodomain and forms a chromatin-remodelling complex with the ISWI homologue SNF2L.
CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.
GeneRIF
Shiekhattar et al., Edmonton, Canada. In Hum Mol Genet, 2005
CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L during neurulation
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