NEDD9 overexpression correlates with poor prognosis in gastric cancer.
Nantong, China. In Tumour Biol, Jul 2014
The upregulated NEDD9 expression in gastric cancer tissue was significantly correlated with high preoperative CEA level (P = 0.044), poor differentiation (P = 0.007), tissue invasion (P = 0.015), present lymph node metastasis (P < 0.001), and high TNM stage (P < 0.001).
Cancer vaccines targeting carcinoembryonic antigen: state-of-the-art and future promise.
Bethesda, United States. In Expert Rev Vaccines, Jun 2013
Concurrent with the US FDA's approval of the first therapeutic cancer vaccine, and supported by mounting clinical evidence indicating that targeting carcinoembryonic antigen (CEA) can safely overcome pre-existing tolerance, a multitude of novel CEA cancer vaccines are now in various stages of development.
[A novel screening method to establish tumor-targeting antibodies reliable for drug delivery system].
Kawagoe, Japan. In Yakugaku Zasshi, 2012
Within these mAbs, we have identified tumor cell target molecules including not only carcinoembryonic antigen (CEA), epithelial cell adhesion molecule (EpCAM), epidermal growth factor receptor (EGFR), prostate specific membrane antigen (PSMA) but also novel tumor surface target molecules such as phosphatidic acid phosphatase type 2a (PAP2a) and interleukin-13 receptor variant α2 (IL-13Rα2) as tumor antigens.