Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol.
Mainz, Germany. In Pharmazie, 2013
Among the candidates were genes involved in apoptosis (STAB2, NUMBL), regulation of transcription (CDYL, FOXA2) and diverse other functional groups (INE1, CTRL, MRS2, NEB, LMO7, C9orf3, EHBP1).
H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing.
Vancouver, Canada. In Epigenetics Chromatin, 2010
Furthermore, using novel ERV reporter constructs targeted to a specific genomic site, we demonstrate that, relative to Setdb1, knockdown of the remaining known H3K9me3 readers expressed in mESCs, including Cdyl, Cdyl2, Cbx2, Cbx7, Mpp8, Uhrf1 and Jarid1a-c, leads to only modest proviral reactivation.
Identification of non-histone substrates for JMJD2A-C histone demethylases.
Kansas City, United States. In Biochem Biophys Res Commun, 2010
A candidate substrate-based approach demonstrated that in addition to its known substrate, trimethylated histone H3-lysine-9, JMJD2A-C demethylate trimethylated lysine containing peptides from WIZ, CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes.