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Chromodomain protein, Y-linked, 1

This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: DAZ, MEN, CAN, POLYMERASE, HAD
Papers on CDY1
Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.
Salekdeh et al., Tehrān, Iran. In J Proteome Res, Oct 2015
We profiled the expression of 41 alternative transcripts encoded by 14 AZFa, AZFb, and AZFc region genes (USP9Y, DDX3Y, XKRY, HSFY1, CYORF15A, CYORF15B, KDM5D, EIF1AY, RPS4Y2, RBMY1A1, PRY, BPY2, DAZ1, and CDY1) as well as their X chromosome homologue transcripts and a few autosomal homologues.
Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.
Modi et al., Mumbai, India. In J Assist Reprod Genet, Sep 2015
PURPOSE: The purpose of this study was to determine the association of AZFc subdeletions (gr/gr, b1/b3 and b2/b3) and deletion of DAZ and CDY1 gene copies with male infertility METHODS: Three hundred twelve controls, 172 azoospermic and 343 oligozoospermic subjects were subjected to AZFc subdeletion typing by STS PCR.
How demanding is the brain on a reversal task under day and night conditions?
Arias et al., Cambridge, United Kingdom. In Neurosci Lett, Aug 2015
We conducted two experiments using the Morris Water Maze under different light-conditions: naïve group (CN, n=8), day group (DY, n=8), control DY group (CDY, n=8) night group (NG, n=8), and control NG group (CNG, n=7).
Screening for AZFc partial deletions in Dravidian men with nonobstructive azoospermia and oligozoospermia.
Suganthi et al., Coimbatore, India. In Genet Test Mol Biomarkers, Mar 2015
Further studies, including gene copy typing for DAZ and CDY genes and a comprehensive haplogrouping analysis, are recommended in a large and well-selected patient group to elude the genetic mechanism behind this association.
Deletion of CDY1b copy of Y chromosome CDY1 gene is a risk factor of male infertility in Tunisian men.
Ammar-Keskes et al., Sfax, Tunisia. In Gene, 2014
RESULTS: Among the 356 Tunisian individuals, 93.25% had the two copies (CDY1a and CDY1b) of CDY gene (91.2% in infertile patients and 97.3% in fertile men).
[Identification of null and duplicated alleles for forensic DYS549, DYS527 and DYS459 in male infertility population].
Cheng et al., Kunming, China. In Yi Chuan, 2014
In this study, we determined the AZF polymorphism by STS(-/-) (sequence tagged site) and DAZ, CDY1 gene copy numbers, and screened the samples by 14 Y-STR loci to disclose the unusual genotype of Y-STR in male infertility population.
High-throughput screening for spermatogenesis candidate genes in the AZFc region of the Y chromosome by multiplex real time PCR followed by high resolution melting analysis.
Corach et al., Buenos Aires, Argentina. In Plos One, 2013
DAZ, CDY, BPY2, PRY, GOLGA2LY and CSGP4LY genes were selected on the basis of their location in the AZFc region, testis-only expression, and confirmed or predicted protein codification.
Partial AZFc duplications not deletions are associated with male infertility in the Yi population of Yunnan Province, China.
Zhao et al., Kunming, China. In J Zhejiang Univ Sci B, 2013
Further, we found a case with sY1206 deletion which had two CDY1 copies but removed half of DAZ genes.
Human Y chromosome microdeletion analysis by PCR multiplex protocols identifying only clinically relevant AZF microdeletions.
Bender et al., Heidelberg, Germany. In Methods Mol Biol, 2012
Partial AZF deletions including single AZF Y genes can cause the same testicular pathology as the corresponding complete deletion (e.g., DDX3Y gene deletions in AZFa), or might not be associated with male infertility at all (e.g., some BPY2, CDY1, DAZ gene deletions in AZFc).
Impaired spermatogenesis and gr/gr deletions related to Y chromosome haplogroups in Korean men.
Shim et al., Seoul, South Korea. In Plos One, 2011
In this study, we characterized partial deletion of AZFc region in Korean patients with spermatogenetic impairment and assessed whether the DAZ and CDY1 contributes to the phenotype in patients with gr/gr deletions.
A preliminary study of copy number variation in Tibetans.
Yu et al., Beijing, China. In Plos One, 2011
The Tibetan CNVRs are enriched for genes in the disease class of human reproduction (such as genes from the DAZ, BPY2, CDY, and HLA-DQ and -DR gene clusters) and biological process categories of "response to DNA damage stimulus" and "DNA repair" (such as RAD51, RAD52, and MRE11A).
CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Yogev et al., Tel Aviv-Yafo, Israel. In Fertil Steril, 2011
Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies.
Genetic dissection of the AZF regions of the human Y chromosome: thriller or filler for male (in)fertility?
Gonçalves et al., Lisbon, Portugal. In J Biomed Biotechnol, 2009
In this regard, evidence supporting the notion that DDX3Y, KDM5D, RBMY1A1, DAZ, and CDY represent key AZF spermatogenic determinants will be discussed.
Partial AZFc deletions and duplications: clinical correlates in the Italian population.
Krausz et al., Florence, Italy. In Hum Genet, 2008
Partial AZFc deletions including CDY1-DAZ gene is associated with impaired spermatogenesis.
Molecular genetics of human male infertility: from genes to new therapeutic perspectives.
Vogt, Heidelberg, Germany. In Curr Pharm Des, 2003
Then some human genes are described well recognised as functional in spermatogenesis and male fertility although gene specific mutations causing infertility were not yet identified (CREM, CDY1, DAZL1, PHGPx, PRM-1, PRM-2).
Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis.
Yavetz et al., Tel Aviv-Yafo, Israel. In Hum Genet, 2003
different functional roles for CDY isoforms during spermatogenesis
[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].
Scandellari et al., Padova, Italy. In Ann Ital Med Int, 2001
Furthermore, it is not clear if all the DAZ copies are expressed in the testis, and other genes, such as CDY1, map in AZFc; therefore their alteration may play a role in determining the phenotype.
Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.
Page et al., Cambridge, United States. In Nat Genet, 1999
The CDY genes have been localized to the human Y chromosome, and we report here that they are derivatives of a conventional single-copy gene, CDYL (CDY-like), located on human chromosome 13 and mouse chromosome 6.
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