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Caudal type homeobox 1

Cdx1, Cdx, Cdx4, cad1
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CDX2, CAN, ACID, HAD, V1a
Papers using Cdx1 antibodies
Age-related changes in VEGF-dependency and angiopoietin-1 induced plasticity of adult blood vessels.
Supplier
Welm Alana L., In PLoS ONE, 2003
... The antibodies against CK-20 (human-specific) and CDX-2 (human-specific) were purchased from DAKO (Carpinteria, CA) ...
Papers on Cdx1
Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study.
New
Štěrba et al., Brno, Czech Republic. In Tumour Biol, Feb 2016
The aims of this study were to investigate selected single nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410; A > G), FokI (rs 2228570; C > T), TaqI (rs731236; T > C), ApaI (rs 7975232; C > T) and Cdx-2 (rs11568820; A > G), and to evaluate their possible predictive role for outcomes in patients with paediatric solid tumours.
CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition.
New
Ho et al., Chicago, United States. In Dev Biol, Feb 2016
Two molecules, retinoic acid (RA) and the Cdx4 transcription factor have been previously implicated as important regulators of hindbrain and spinal cord development, respectively.
Application of sequencing, liquid biopsies and patient-derived xenografts for personalized medicine in melanoma.
New
Marais et al., Manchester, United Kingdom. In Cancer Discov, Jan 2016
We also developed circulating tumor cell-derived xenografts (CDX) as an alternative to PDXs when tumors were inaccessible or difficult to biopsy.
Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma.
New
Lu et al., Changsha, China. In Oncotarget, Jan 2016
Moreover, the bisulfite-sequencing of genes MLH1, CDH5, TWIST1 and CDX1 confirmed the methylation status identified by MeDIP-Seq.
[Trends and Challenges of the Statutory Regulation of Molecular Genetic Tests].
Review
New
Nobori, In Rinsho Byori, Jul 2015
Such tests are developed together with drugs, involving mainly molecular genetic tests at present, and are called companion diagnostics (CDx).
Companion Diagnostics and Molecular Imaging.
Review
New
Baum et al., Germany. In Cancer J, May 2015
Companion diagnostics (CDx) is a positive attempt in the direction of improving the drug development process, especially in the field of oncology, with the advent of newer targeted therapies.
Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer.
Review
New
Akhavan-Niaki et al., Bābol, Iran. In Med Oncol, Mar 2015
Correspondingly, KLF5, CDX1/2, WNT1 and FEM1A are considerable genes in gastric cancer, although many researches and studies have illustrated that sonic hedgehog and expression of its signaling cascade proteins are related in gastric cancer.
BRACAnalysis CDx as a companion diagnostic tool for Lynparza.
Review
Moore et al., Oklahoma City, United States. In Expert Rev Mol Diagn, 2014
Lynparza and its companion diagnostic test, BRACAnalysis were approved by the US FDA in December 2014 for recurrent ovarian cancer in women with a germline BRCA mutation.
Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes.
Impact
Adamska et al., Bergen, Norway. In Nature, 2014
Our phylogenetic analyses demonstrate that these calcisponges possess orthologues of bilaterian NK genes (Hex, Hmx and Msx), a varying number of additional NK genes and one ParaHox gene, Cdx.
CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast.
Review
Gómez-Macías et al., Monterrey, Mexico. In Biol Res, 2013
Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2.
Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis.
GeneRIF
Fainsod et al., Jerusalem, Israel. In Faseb J, 2012
Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
Cdx function is required for maintenance of intestinal identity in the adult.
GeneRIF
Lohnes et al., Ottawa, Canada. In Dev Biol, 2012
The findings suggested that Cdx2 is essential for differentiation of the small intestinal epithelium, and that both Cdx1 and Cdx2 contribute to homeostasis of the colon.
Cdx regulates Dll1 in multiple lineages.
GeneRIF
Lohnes et al., Ottawa, Canada. In Dev Biol, 2012
Cdx members operate upstream of Dll1 to convey different functions in both somitogenesis and Goblet cell differentiation.
Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2.
GeneRIF
Eloranta et al., Zürich, Switzerland. In Am J Physiol Gastrointest Liver Physiol, 2012
The human ASBT promoter was activated transcriptionally by CDX1 and CDX2.
Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
GeneRIF
Deschamps et al., Utrecht, Netherlands. In Development, 2011
Compound mutants carrying one active Cdx2 allele in the Cdx4-null background (Cdx2/4), transgenic embryos precociously expressing Hox13 genes and a novel Wnt3a hypomorph mutant all manifest a comparable phenotype with similar uro-rectal defects
Self-Consistent-Charge Density-Functional Tight-Binding Parameters for Cd-X (X = S, Se, Te) Compounds and Their Interaction with H, O, C, and N.
Frauenheim et al., India. In J Chem Theory Comput, 2011
Parameters for CdX, SeX, and TeX (X = H, C, N, O, S, Se, Te, and Cd) have been generated within the self-consistent-charge density-functional tight-binding (SCC-DFTB) framework.
Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression.
Impact
Pei et al., Shanghai, China. In Cell, 2009
In addition, the expression of cdx4, a critical regulator of embryonic blood formation, and its downstream hox genes were downregulated by depletion of beta-arrestin1, while injection of cdx4, hoxa9a or hoxb4a mRNA rescued the hematopoietic defects.
Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer.
Impact
Christiani et al., United States. In J Clin Oncol, 2009
PATIENTS AND METHODS: We evaluated the relationship between circulating 25-hydroxyvitamin D levels; VDR polymorphisms, including Cdx-2 G>A (rs11568820), FokI C>T (rs10735810), and BsmI C>T (rs144410); and overall survival among patients with advanced NSCLC.
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.
Impact
Daley et al., Boston, United States. In Cell Stem Cell, 2008
When BMP signaling is blocked during this latter phase, enforced expression of either Cdx1 or Cdx4 rescues hematopoietic development, thereby placing BMP4 signaling upstream of the Cdx-Hox pathway.
Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3.
Impact
Green et al., Worcester, United States. In Nature, 2008
Zebrafish embryos depleted of Trf3 or Mespa also failed to express cdx4, a caudal-related gene required for haematopoiesis.
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