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Abhydrolase domain containing 5

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, OUT, HAD
Papers on CdS
An MMP-2 responsive liposome integrating anti-fibrosis and chemotherapeutic drugs for enhanced drug perfusion and efficacy in pancreatic cancer.
Nie et al., In Acs Appl Mater Interfaces, Feb 2016
One part was constituted by the β-CDs and the anti-fibrosis drug pirfenidone which was kept in the stroma and inhibited the expression of collagen I and TGF-β in PSCs, down-regulating the fibrosis and decreasing the stromal barrier.
Probing Bioluminescence Resonance Energy Transfer in Quantum Rod - Luciferase Nanoconjugates.
Maye et al., In Acs Nano, Feb 2016
By fine-tuning the synthetic conditions, CdSe/CdS r/r-QRs were prepared with two different emission colors and three different aspect ratios (l/w) each.
Lectin-carbohydrate recognition mechanism of Plasmodium berghei in the midgut of malaria vector Anopheles stephensi using quantum dot as a new approach.
Abai et al., Tehrān, Iran. In Acta Trop, Feb 2016
Two QDs, cadmium telluride (CdTe)/CdS and cadmium selenide (CdSe)/CdS, were employed in staining Plasmodium ookinete to study its interaction in the midgut of the mosquito vector in vivo.
A fluorescence resonance energy transfer (FRET) based "Turn-On" nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobalt oxyhydroxide nanosheet architecture and application to α-glucosidase inhibitor screening.
Wu et al., Qufu, China. In Biosens Bioelectron, Jan 2016
With hydrolysis of AAG by α-glucosidase, ascorbic acids (AA) were released that can rapidly reduce CoOOH nanoflakes to Co(2+), and then FRET was stopped accompanying with the fluorescence recovery of CDs.
Diorganyl Dichalcogenides as Useful Synthons for Colloidal Semiconductor Nanocrystals.
Brutchey, Los Angeles, United States. In Acc Chem Res, Dec 2015
These combined attributes have allowed dichalcogenide precursors to be employed for a wide range of metal chalcogenide nanocrystal syntheses, including those for In2S3, SnxGe1-xSe, SnTe, Cu2-xSySe1-y, ZnSe, CdS, CdSe, MoSe2, WSe2, BiSe, and CuFeS2.
Pharmacokinetics of cyclodextrins and drugs after oral and parenteral administration of drug/cyclodextrin complexes.
Concheiro et al., Reykjavík, Iceland. In J Pharm Pharmacol, Jul 2015
OBJECTIVES: The objective of the present study was to shed some light on pharmacokinetics of cyclodextrins (CDs) and drugs after oral and parenteral administration of inclusion complexes.
Supramolecular cyclodextrin-based drug nanocarriers.
Alvarez-Lorenzo et al., Coimbra, Portugal. In Chem Commun (camb), May 2015
Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances.
Reemergence of chloroquine (CQ) analogs as multi-targeting antimalarial agents: a review.
Shahjahan et al., Farīdābād, India. In Eur J Med Chem, Feb 2015
Amongst several communicable diseases (CDs), malaria is one of the deadliest parasitic disease all over the world, particularly in African and Asian countries.
Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex.
Ruktanonchai et al., Thailand. In Beilstein J Org Chem, 2014
Cyclodextrins (CDs) have been extensively utilized as host molecules to enhance the solubility, stability and bioavailability of hydrophobic drug molecules through the formation of inclusion complexes.
Cell-cell interactions driving kidney morphogenesis.
Little et al., Brisbane, Australia. In Curr Top Dev Biol, 2014
Subsequent fusion to the CDs, nephron segmentation and maturation, and formation of a patent glomerular basement membrane also require specialized cell-cell interactions.
Fluorescent carbon dots for biolmaging and biosensing applications.
Meng et al., In J Biomed Nanotechnol, 2014
Due to the excellent biocompatibility, carbon dots (CDs), which are attracting considerable attention as new quantum-sized carbon-containing fluorescent nanoparticles, are becoming both an important class of imaging probes and a versatile platform for biosensors.
A low-cost non-toxic post-growth activation step for CdTe solar cells.
Durose et al., Liverpool, United Kingdom. In Nature, 2014
This acts to form the photovoltaic junction at the CdTe/CdS interface and to passivate the grain boundaries, making it essential in achieving high device efficiencies.
Supramolecular polymeric materials via cyclodextrin-guest interactions.
Nakahata et al., Toyonaka, Japan. In Acc Chem Res, 2014
CONSPECTUS: Cyclodextrins (CDs) have many attractive functions, including molecular recognition, hydrolysis, catalysis, and polymerization.
Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications.
Chu et al., Hangzhou, China. In Acc Chem Res, 2014
Cyclodextrins (CDs), which possess a hydrophilic exterior surface and hydrophobic interior cavity on the truncated cone, improve the biocompatibility of nanodelivery systems, and hence, supramolecular approaches utilizing CDs can improve and expand the design and applications of functional delivery systems.
Synthesis and patterning of tunable multiscale materials with engineered cells.
Lu et al., Cambridge, United States. In Nat Mater, 2014
We also interfaced curli fibrils with inorganic materials, such as gold nanoparticles (AuNPs) and quantum dots (QDs), and used these capabilities to create an environmentally responsive biofilm-based electrical switch, produce gold nanowires and nanorods, co-localize AuNPs with CdTe/CdS QDs to modulate QD fluorescence lifetimes, and nucleate the formation of fluorescent ZnS QDs.
Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58.
Moro et al., Toulouse, France. In J Lipid Res, 2012
an important metabolic function of CGI-58 in skeletal muscle
Steatohepatitis and liver cirrhosis in Chanarin-Dorfman syndrome with a new ABDH5 mutation.
Ozer et al., Sivas, Turkey. In Clin Res Hepatol Gastroenterol, 2012
A report of two Chanarin-Dorfman syndrome sisters with severe steatohepatitis and decompensated cirrhosis due to steatohepatitis in whom the clinical presentation developed due to a new mutation in ABHD5 gene.
Novel nonsense mutation of ABHD5 in Dorfman-Chanarin syndrome with unusual findings: a challenge for genotype-phenotype correlation.
Ahuja et al., New Delhi, India. In Eur J Med Genet, 2012
A novel nonsense mutation of ABHD5 is reported in a consanguineous Afgani family with 4 sibs with Dorfman Chanarin syndrome; the mutation leads to protein truncation by 14 AAs; findings include liver cirrhosis, corneal opacities,tessellated fundus
CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action.
Brown et al., Winston-Salem, United States. In Diabetes, 2012
show that CGI-58 is required for the generation of signaling lipids in response to inflammatory stimuli and that lipid second messengers generated by CGI-58 play a critical role in maintaining the balance between inflammation and insulin action
The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.
Oberer et al., Graz, Austria. In Plos One, 2010
minimal fragment of ATGL could still be activated and inhibited by CGI-58 and G0S2, respectively
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