gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cerebellar degeneration-related protein 2, 62kDa

CDR2
Top mentioned proteins: ETO, ACID, CAN, HAD, MHC
Papers on CDR2
Molecular mechanisms associated with Fluconazole resistance in clinical Candida albicans isolates from India.
New
Risbud et al., Pune, India. In Mycoses, Feb 2016
Target site (ERG11) alterations were determined by DNA sequencing, whereas real-time PCRs were performed to quantify target and efflux pump genes (CDR1, CDR2, MDR1) in 87 [Fluconazole susceptible (n = 30), susceptible-dose dependent (n = 30) and resistant (n = 27)] C.albicans isolates.
Overcoming low yields of plant-made antibodies by a protein engineering approach.
New
Fischer et al., Aachen, Germany. In Biotechnol J, Jan 2016
Analysis of the expression levels showed that: i) 4E10 yields were only marginally increased by suppression of post-transcriptional gene silencing; ii) the CDR3 of 4E10 contains a protease site; and iii) a bipartite, yield-limiting region exists in the CDR2/CDR3.
Epiregulin Recognition Mechanisms by Anti-Epiregulin Antibody 9E5: Structural, Functional and Molecular Dynamics Simulation Analyses.
New
Inoue et al., Ōsaka, Japan. In J Biol Chem, Jan 2016
Among the six complementarity-determining regions (CDRs), CDR1-3 in the light chain and CDR2 in the heavy chain predominantly recognize EPR.
Mycologic Endocrinology.
Review
New
Stevens et al., San Jose, United States. In Adv Exp Med Biol, Dec 2015
Genome expression profiles of C. albicans in the presence of estradiol or progesterone, and S. cerevisiae with progesterone, indicate major up-regulation of various drug resistance pumps, like CDR1, and CDR2, can affect antifungal susceptibility.
The correlation of virulence, pathogenicity, and itraconazole resistance with SAP activity in Candida albicans strains.
New
Ma et al., Shancheng, China. In Can J Microbiol, Dec 2015
The relative expression levels of CDR1, CDR2, MDR1, and SAP2 were measured using RT-PCR.
[Investigation of mutations in transcription factors of efflux pump genes in fluconazole-resistant Candida albicans strains overexpressing the efflux pumps].
New
Doluca Dereli et al., Çankırı, Turkey. In Mikrobiyol Bul, Oct 2015
The efflux pumps mainly involved are Cdr1, Cdr2 ve Mdr1 encoded by CDR1, CDR2 and MDR1 genes.
Paraneoplastic neurological syndromes associated with ovarian tumors.
Review
Michalak et al., Poznań, Poland. In J Cancer Res Clin Oncol, 2015
Since ovarian tumors and nervous tissue share common antigens (e.g., cdr2, NMDAR), autoimmune etiology is a probable mechanism of these neurologic disorders.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.
Estimation of Candida albicans ABC Transporter Behavior in Real-Time via Fluorescence.
Krasowska et al., Wrocław, Poland. In Front Microbiol, 2014
Addition of glucose to the cell suspension resulted in Cdr1p transporter expression in the CDR2-knockout strain.
T cells and their eons-old obsession with MHC.
Review
Marrack et al., Denver, United States. In Immunol Rev, 2012
However, recent experiments by our group and others suggest that one group of TCR variable elements, those related to the mouse Vβ8 family, has amino acids in their CDR2 regions that consistently bind a particular site on an MHC α-helix.
Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo--associated paraneoplastic cerebellar degeneration.
GeneRIF
Graus et al., Huelva, Spain. In Neuro Oncol, 2012
This study shows a very high frequency of HER2 overexpression in breast cancers in patients with anti-Yo-associated paraneoplastic cerebellar degeneration.
Evolutionarily conserved features contribute to αβ T cell receptor specificity.
Impact
Gapin et al., Denver, United States. In Immunity, 2011
Sequence comparisons showed that some Vβs from distantly related jawed vertebrates share amino acids in their complementarity determining region 2 (CDR2).
CDR2 antigen and Yo antibodies.
GeneRIF
Vedeler et al., Bergen, Norway. In Cancer Immunol Immunother, 2011
The results suggest that Yo antibodies are not only related to the expression of CDR2 alone, but also to immune dysregulation.
Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo).
GeneRIF
Vedeler et al., Bergen, Norway. In Cancer Immunol Immunother, 2010
The association between Yo and CCDC104 antibodies in paraneoplastic neurological syndromes may indicate functional similarities.
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response.
GeneRIF
Camenisch et al., Zürich, Switzerland. In Oncogene, 2009
Cdr2 protein strongly accumulates in papillary renal cell carcinoma, attenuates the HIF response to tumor hypoxia and may become of diagnostic importance as novel renal tumor marker.
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.
Impact
Gapin et al., Denver, United States. In Immunity, 2009
We showed that the V beta bias occurred as a consequence of the CDR2 beta loops determining the affinity of the iNKT TCR for CD1d-glycolipids, thus controlling positive selection.
Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors.
Impact
Rossjohn et al., Melbourne, Australia. In Immunity, 2009
Mutagenesis studies revealed the differing contributions of V beta 8.2 and V beta 7 residues within the CDR2 beta loop in mediating contacts with CD1d.
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.
Impact
Kappler et al., Denver, United States. In Immunity, 2008
A few CDR1 and CDR2 amino acids dominated the most crossreactive TCR interface with MHC, including Vbeta8 48Y and 54E and Valpha4 29Y, arranged to impose the familiar diagonal orientation of TCR on MHC.
Evolutionarily conserved amino acids that control TCR-MHC interaction.
Review
Impact
Kappler et al., Denver, United States. In Annu Rev Immunol, 2007
Relatively conserved amino acids in the TCR complementarity-determining regions (CDR) 1 and CDR2 are often used to bind exposed areas of the MHC alpha-helices.
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21).
GeneRIF
Frade et al., Rouen, France. In Fems Microbiol Lett, 2005
Mycoplasma fermentans, in infecting human B cells, generates a Mycoplasma component that interacts with CD21, which is involved in B cell proliferation.
share on facebooktweetadd +1mail to friends