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Cyclin-dependent kinase 3

cdk3, cyclin-dependent kinase 3
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK2, CDK4, CDC2, pRb
Papers on cdk3
miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.
Xie et al., Guangzhou, China. In Oncotarget, Nov 2015
Direct binding of miR-214 to the 3'-untranslated regions of E2F2, CDK3, and CDK6 was verified by dual-luciferase reporter assay.
MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells.
Zhang et al., Beijing, China. In Oncogene, Aug 2015
Reporter gene assays revealed cyclin-dependent kinase 3 (CDK3) as a direct target of miR-873.
Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells.
Cózar-Castellano et al., Valladolid, Spain. In Am J Physiol Endocrinol Metab, Apr 2015
Quiescent fibroblasts exit from G0 (quiescence) to G1 through pRb phosphorylation mediated by cyclin C/cdk3 complexes.
Paraptosis cell death induction by the thiamine analog benfotiamine in leukemia cells.
Nakao et al., Kanazawa, Japan. In Plos One, 2014
In addition, benfotiamine induced the down regulation of the cell cycle regulator CDK3 which resulted in G1 cell cycle arrest in the sensitive leukemic cells.
Cyclin C is a haploinsufficient tumour suppressor.
Sicinski et al., Boston, United States. In Nat Cell Biol, 2014
Cyclin C activates an 'orphan' CDK19 kinase, as well as CDK8 and CDK3.
Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine embryos in vitro.
Madan et al., Guelph, Canada. In Theriogenology, 2014
Measurement of relative expression using real-time polymerase chain reaction of a some cell cycle-related genes and microRNAs in treated donor cells showed decreased expression of HDAC1, DNMT1, P53, CYC E1, and CDK4 and increased expression of DNMT3a, CDKN1A, CDK2, CDK3, miR-15a, miR-16, and miR-34a (P<0.05).
CDK3 expression and its clinical significance in human nasopharyngeal carcinoma.
Zheng et al., Shenzhen, China. In Mol Med Report, 2014
The aim of the current study was to investigate the expression of cyclin-dependent kinase 3 (CDK3) in human nasopharyngeal carcinoma (NPC) and to evaluate its association with the clinicopathological characteristics of patients with NPC.
Static and dynamic protein phosphorylation in the Vaccinia virion.
Gershon et al., Chapel Hill, United States. In Virology, 2014
The MV phosphoproteome was enriched in potential substrates of cellular kinases belonging to the CDK2/CDK3, CK2, and p38 groups.
[CDK3 expression and its clinical significance in human nasopharyngeal carcinoma].
Zheng et al., Shenzhen, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2013
OBJECTIVE: To investigate the expression profile and the clinical significance of CDK3 in the tissues of nasopharyngeal carcinoma.
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
Groop et al., Malmö, Sweden. In Mol Cell Endocrinol, 2013
Expression of CDKN1A, CDKN2A, CCNI2, CDK3 and CDK16 was correlated with age.
BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application.
Ziegelbauer et al., Berlin, Germany. In Mol Cancer Ther, 2012
BAY 1000394 inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.
Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.
Gespach et al., Saint-Pierre-des-Corps, France. In Int J Oncol, 2012
The EMT caused dominance of several proinvasive pathways downstream of GPR, including GαGβγ subunits, PKCα, AKT and c-Jun induction, constitutive activation of the actin-remodeling GTPase Rac1, coupled with growth responses (more cells at S and G2/M phases of the cell cycle), in line with inhibition of the p27kip1/cyclin-dependent kinase CDK3 cascade.
Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas.
Song et al., Seoul, South Korea. In Plos One, 2011
In particular, cyclin A2 (CCNA2), CCND1, CCND2, CCND3, CCNE2, cyclin dependent kinase 1 (CDK1), CDK3, CDK5, cyclin dependent kinases inhibitor 1A (CDKN1A) and CDKN1B were upregulated predominantly in the glandular epithelia of cancerous ovaries from laying hens.
Structure of a cyclin-dependent kinase from Giardia lamblia.
Van Voorhis et al., Seattle, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
Although the structure of GlCDK with its associated cyclin was not solved, the 1.85 Å resolution structure of apo GlCDK and a 2.0 Å resolution structure of GlCDK in complex with adenosine monophosphate are presented and the structural differences from the orthologous human CDK2 and CDK3 are discussed.
The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.
Rovnak et al., Fort Collins, United States. In Virology, 2011
The Walleye dermal sarcoma virus cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 and Cdk3.
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.
Dong et al., Austin, United States. In Cancer Res, 2008
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1.
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
Rollins et al., Boston, United States. In Cell, 2004
A non-cdk8-associated cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
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