Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.
In PLoS Pathogens, 2005
... aphidicolin (Sigma-Aldrich, final concentration: 5 µg/ml), hydroxyurea (Sigma-Aldrich, 1 mM), roscovitine (Millipore-Calbiochem, 5–50 µM), CVT313 (purchased as CDK2 inhibitor III from Millipore-Calbiochem, 10–50 µM), SU9516 (Santa Cruz Biotechnology, Santa Cruz, CA, USA, ... Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNFmore suppliers
In Oncogene, 1999
... Louis, MO, USA), p38 inhibitor (SB 203580, Millipore, Billerica, MA, USA), Cdk2 inhibitor (Roscovitine, Sigma Aldrich), Cdk4 inhibitor (EMD, Darmstadt, ...
Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.
Shanghai, China. In Oncotarget, Feb 2016
Here, we show that Bufalin can inhibit cervical cancer cell proliferation, block cell cycle in G2/M phase, induce cellular apoptosis and reduce cell metastasis through stimulation of p21waf/cip1, p27cip/kip, Bax and E-cadherin, and suppression of cyclin A, cyclin B1, CDK2, Bcl-2, Bcl-xl, MMP9 and SNAIL1.
Linker histones in hormonal gene regulation.
Spain. In Biochim Biophys Acta, Nov 2015
A complex sequence of enzymatic events, including phosphorylation by CDK2, PARylation by PARP1 and the ATP-dependent activity of NURF, are required for H1 displacement and gene de-repression, as a prerequisite for further nucleosome remodeling.
Roscovitine in cancer and other diseases.
Genève, Switzerland. In Ann Transl Med, Jun 2015
It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.
Control of Drosophila endocycles by E2F and CRL4(CDT2).
More papers using
Heidelberg, Germany. In Nature, 2012
DNA replication in endocycling Drosophila cells is triggered by cyclin E/cyclin dependent kinase 2 (CYCE/CDK2), but this kinase must be inactivated during each G-phase to allow the assembly of pre-Replication Complexes (preRCs) for the next S-phase.