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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cadherin 23

CDH23, cadherin 23, USH1D, DFNB12
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010] (from NCBI)
Papers on CDH23
Association of cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese.
GeneRIF
Liu et al., Taipei, Taiwan. In Otolaryngol Head Neck Surg, 2012
Despite that the Ahl allele of Cdh23 had been implicated with ARHI in mice, we found no positive association of the CDH23 tag SNP in intron 7 with ARHI in Han Chinese.
A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.
GeneRIF
Zheng et al., Cleveland, United States. In Gene, 2012
the Cdh23(nmf308/nmf308) mice with progressive hair cell loss had specific morphological changes and suffered a base to apex gradient and age-related hearing loss (AHL), and that mutations in cdh23 were linked to AHL
Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.
GeneRIF
Johnson et al., Bar Harbor, United States. In Hear Res, 2012
Although Cdh23(ahl) homozygosity is necessary, it is not by itself sufficient to account for the accelerated hearing loss of C57BL/6J mice.
Role for a novel Usher protein complex in hair cell synaptic maturation.
GeneRIF
Cosgrove et al., Omaha, United States. In Plos One, 2011
A novel synaptic Usher complex comprised of clarin-1 and specific isoforms of CDH23, PCDH15 and VLGR1, was identified.
Cadherin-23 mediates heterotypic cell-cell adhesion between breast cancer epithelial cells and fibroblasts.
GeneRIF
Ligon et al., Troy, United States. In Plos One, 2011
cadherin-23 is up-regulated in breast cancer tissue versus normal tissue and we propose that cadherin-23-mediated heterotypic adhesion between invading tumor cells and stromal fibroblasts may play a role in the metastatic cascade.
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