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Cadherin 19, type 2

CDH19, Cadherin-19, CDH7L2
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cadherin-7, POLYMERASE, HAD, p16, R-cadherin
Papers on CDH19
Expression changes of cell-cell adhesion-related genes in colorectal tumors.
Siedlecki et al., Warsaw, Poland. In Oncol Lett, Jun 2015
Between these tissue types, differences were observed in the mRNA levels of genes encoding adherens junction proteins (upregulation of CDH3 and CDH11, and downregulation of CDH19 and PTPRF), tight junction proteins (upregulation of CLDN1 and CLDN2, and downregulation of CLDN5, CLDN8, CLDN23, CLDN15, JAM2 and CGN) and desmosomes (upregulation of DSC3 and DSG3, and downregulation of DSC2), in addition to a decrease in the expression of certain other genes involved in intercellular connections: PCDHB14, PCDH7, MUPCDH and NEO1.
Myelin-forming cell-specific cadherin-19 is a marker for minimally infiltrative glioblastoma stem-like cells.
Kuo et al., In J Neurosurg, 2015
Cadherin-19 (CDH19) protein expression was enhanced in minimally infiltrative GSC lines.
High-Resolution Array Comparative Genomic Hybridization Utility in Polish Newborns with Isolated Cleft Lip and Palate.
Bocian et al., Warsaw, Poland. In Neonatology, 2014
In addition, 2 novel candidate genes for cleft lip and palate, CHN2 and CDH19, are suggested.
Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer.
Pylkäs et al., Oulu, Finland. In Bmc Cancer, 2013
The two others were recurrent alleles and disrupted CDH19 and CYP2C19 genes.
Recurrent pre-existing and acquired DNA copy number alterations, including focal TERT gains, in neuroblastoma central nervous system metastases.
Cheung et al., New York City, United States. In Genes Chromosomes Cancer, 2013
Based on minimal common regions, gene expression, and biological properties, TERT (5p), NR2F2 (15q), ALDH1A3 (15q), CDKN2A (9p), and possibly CDH7 and CDH19 (18q) were candidate genes associated with the CNS metastatic process.
Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study.
Knuutila et al., Helsinki, Finland. In Cancer Genet, 2012
Deletions were also found to affect genes of the cadherin family, including CDH4 and CDH7, each of which had a targeted homozygous loss in one case, and CDH19, which had a targeted homozygous loss in two cases.
Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays.
Sudhoff et al., Bielefeld, Germany. In Plos One, 2011
Three cell communication genes were identified; one CDH19 and two from the S100 family.
A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect.
Slavotinek et al., San Francisco, United States. In Am J Med Genet A, 2010
Mapping of this deletion using fluorescence in situ hybridization revealed three deleted genes-CDH19, DSEL, and TXNDC10, and one gene that contained the deletion breakpoint, CCDC102B.
Cadherin-19 expression is restricted to myelin-forming cells in the chicken embryo.
Redies et al., Jena, Germany. In Neuroscience, 2010
We cloned chicken cadherin-19 that demonstrates high similarity to human and rat cadherin-19.
Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP).
Kolattukudy et al., Orlando, United States. In J Biol Chem, 2008
Chromatin immunoprecipitation analysis revealed that cadherin (cdh) 12 and cdh19 are in vivo targets of MCPIP.
A novel locus for ectodermal dysplasia of hairs, nails and teeth type maps to chromosome 18q22.1-22.3.
Ahmad et al., Islamabad, Pakistan. In Ann Hum Genet, 2008
Three candidate genes, CDH7, CDH19 and ZNF407, from the linkage interval were sequenced and found to be negative for functional sequence variants.
Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system.
Osumi et al., Sendai, Japan. In Bmc Dev Biol, 2007
We reported previously the expression of cadherin19 (cad19) in Schwann cell precursors.
Cadherin expression in the developing chicken cochlea.
Redies et al., Jena, Germany. In Dev Dyn, 2007
Three closely related cadherins (cadherin-7, cadherin-19, and cadherin-20) are expressed in a partially complementary manner in spindle-shaped cells and acoustic ganglion cells.
Identification of a novel type II classical cadherin: rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development.
Osumi et al., Sendai, Japan. In Dev Dyn, 2005
To identify a novel type II classical cadherin, we searched the genome database and found rat cadherin19 (cad19) with high similarity to human cadherin19.
Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma.
Laurent-Puig et al., Paris, France. In Oncogene, 2002
Four known genes (CDH7, CDH19, DNAM-1, FLJ23594) located in this critical region and two EST clusters (Hs.96900,
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