gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 18, type 2

CDH18, cadherin 18, type 2, EY-cadherin
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cadherin-10, M-cadherin, AGE, cadherin-11, cadherin-6
Papers on CDH18
Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort.
Ness et al., Memphis, United States. In Cancer, Jun 2015
SNPs within the glycine receptor α3 (GLRA3) gene and near the sex-determining region Y box 11 (SOX11) and cadherin 18 type 2 (CDH18) genes also were identified.
A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.
Kissebah et al., Milwaukee, United States. In Bmc Med Genomics, 2012
Four genes were highly prioritized: cadherin 18 (CDH18), myosin X (MYO10), anchor protein 6 of AMPK (AKAP6), and neuronal PAS domain protein 3 (NPAS3).
Cadherins and neuropsychiatric disorders.
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients.
Kuiper et al., Nijmegen, Netherlands. In Int J Cancer, 2011
We employed genome-wide copy number profiling using high-resolution SNP arrays on germline DNA, which resulted in the identification of novel copy number variants (CNVs) in six patients (15%) encompassing, among others, the cadherin gene CDH18, the bone morphogenetic protein antagonist family gene GREM1, and the breakpoint cluster region gene BCR.
[Expressions of cadherin molecules CDH18 and PCDH17 in human azoospermic testes].
Kang et al., Xi'an, China. In Zhonghua Nan Ke Xue, 2009
Azoospermic testis showed down-regulation of CDH18 and PCDH17.
Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts).
Leivo et al., Turku, Finland. In J Dent Res, 2007
including the cell-adhesion-related gene cadherin 18 (CDH18) and leukocyte cell adhesion molecule (ALCAM, MEMD).
Expression analysis of SIX3 and SIX6 in human tissues reveals differences in expression and a novel correlation between the expression of SIX3 and the genes encoding isocitrate dehyhrogenase and cadherin 18.
Clark et al., London, United Kingdom. In Genomics, 2005
Using this powerful technique, we have detected a novel statistical correlation between the spatial distribution and the quantitative expression of SIX3 and 5 other transcripts including IDH1, the gene encoding the NADP(+)-dependent enzyme isocitrate dehydrogenase, and cadherin 18, type 2 (CDH14).
The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.
van Roy et al., Gent, Belgium. In Febs Lett, 1999
By FISH analysis the genomic location was determined at human chromosome 5p13-14, which is nearby the reported positions of the human cadherin-6, -12, and cadherin-14 (CDH18) genes.
Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye.
Tan et al., Australia. In Exp Neurol, 1999
EY-cadherin is most closely related to human Cadherin-14 (93% identical).
share on facebooktweetadd +1mail to friends