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Cadherin 12, type 2

CDH12, Br-cadherin, N-cadherin 2, cadherin-12
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: N-cadherin, OUT, CDH13, TUBE, cadherin-9
Papers on CDH12
Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT.
New
Lu et al., Shanghai, China. In Tumour Biol, Feb 2016
UNASSIGNED: Cadherin-12 (CDH12) is a subtype of N-cadherin family.
Polygenic associations of neurodevelopmental genes in suicide attempt.
New
Wasserman et al., Stockholm, Sweden. In Mol Psychiatry, Jan 2016
Among the 590 SA polygenes implicated here, there were several developmentally important functions (cell adhesion/migration, small GTPase and receptor tyrosine kinase signaling), and 16 of the SA polygenes have previously been studied in SB (BDNF, CDH10, CDH12, CDH13, CDH9, CREB1, DLK1, DLK2, EFEMP1, FOXN3, IL2, LSAMP, NCAM1, nerve growth factor (NGF), NTRK2 and TBC1D1).
The strength of combined cytogenetic and mate-pair sequencing techniques illustrated by a germline chromothripsis rearrangement involving FOXP2.
Tommerup et al., Copenhagen, Denmark. In Eur J Hum Genet, 2014
We identified three truncated genes: CDH12, DGKB and FOXP2, confirming the role of FOXP2 in severe speech disorder, and suggestive roles of CDH12 and/or DGKB for the global developmental and psychomotor delay.
Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models.
Cox et al., Vancouver, Canada. In Carcinogenesis, 2012
The fERG-induced EMT transcript signature was exemplified by suppressed expression of E-cadherin and keratins 5, 8, 14 and 18; elevated expression of N-cadherin, N-cadherin 2 and vimentin, and of the EMT transcriptional regulators Snail, Zeb1 and Zeb2, and lymphoid enhancer-binding factor-1 (LEF-1).
Cadherin-12 contributes to tumorigenicity in colorectal cancer by promoting migration, invasion, adhersion and angiogenesis.
Lu et al., Shanghai, China. In J Transl Med, 2012
BACKGROUND: Cadherin 12 (CDH12), which encodes a type II classical cadherin from the cadherin superfamily, may mediate calcium-dependent cell adhesion.
Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.
Zhang et al., Xinxiang, China. In Oncol Lett, 2012
We performed whole-exome sequencing for a pleomorphic cell-type HCC tissue and matched normal tissue, and uncovered seven non-synonymous somatic variants in SPATA21, PPCS, CDH12, OR1L3, PCK2, HUWE1 and PHF16.
Cadherins and neuropsychiatric disorders.
Review
Hübner et al., Jena, Germany. In Brain Res, 2012
For example, CDH15 and PCDH19 are associated with cognitive impairment; CDH5, CDH8, CDH9, CDH10, CDH13, CDH15, PCDH10, PCDH19 and PCDHb4 with autism; CDH7, CDH12, CDH18, PCDH12 and FAT with bipolar disease and schizophrenia; and CDH11, CDH12 and CDH13 with methamphetamine and alcohol dependency.
Genome-wide association of BMI in African Americans.
Bowden et al., Winston-Salem, United States. In Obesity (silver Spring), 2012
These loci are located near PP13439-TMEM212, CDH12, MFAP3-GALNT10, and FER1L4 and had effect sizes between 0.091 and 0.167 s.d. unit (or 0.67-1.24
CDH12 promotes the invasion of salivary adenoid cystic carcinoma.
GeneRIF
Lu et al., Fuzhou, China. In Oncol Rep, 2011
CDH12 may play an important role in the invasion and metastasis of salivary adenoid cystic carcinoma
Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain.
GeneRIF
Lele et al., Budapest, Hungary. In Gene Expr Patterns, 2010
spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR.
Caballín et al., Barcelona, Spain. In Genomics, 2010
Six genes confirmed array CGH data, and four of them appeared to have bona fide HLS duplications (ABCB10, E2F6, CDH12, and TDG genes).
Identification of genes associated with non-small-cell lung cancer promotion and progression.
GeneRIF
Tanic et al., Belgrade, Serbia. In Lung Cancer, 2010
E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses
Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.
Craddock et al., Cardiff, United Kingdom. In Br J Psychiatry, 2009
Genes having at least one associated polymorphism at P<10(-4) included B3GALTS, A2BP1, GABRB1, AUTS2, BSN, PTPRG, GIRK2 and CDH12.
Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP).
Kolattukudy et al., Orlando, United States. In J Biol Chem, 2008
Transfection of HUVECs with MCPIP expression vector activated the expression of cdh12 and cdh19 genes.
Primate-specific spliced PMCHL RNAs are non-protein coding in human and macaque tissues.
Nahon et al., Antibes, France. In Bmc Evol Biol, 2007
Sequencing of PMCHL genes in several non-human primates allowed to carry out phylogenetic analyses revealing that the initial retroposition event took place within an intron of the brain cadherin (CDH12) gene, soon after platyrrhine/catarrhine divergence, i.e. 30-35 Mya, and was concomitant with the insertion of an AluSg element.
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