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Cell division cycle 6 homolog

Cdc6, Cdc6p
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CAN, Origin Recognition Complex, MCM2, CDC2
Papers on Cdc6
Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.
New
Méndez et al., Madrid, Spain. In Cell Cycle, Jan 2016
Cdc6 encodes a key protein for DNA replication, responsible for the recruitment of the MCM helicase to replication origins during the G1 phase of the cell division cycle.
De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.
New
Yang et al., Houston, United States. In Am J Hum Genet, Jan 2016
Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6.
Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.
New
Dong et al., Australia. In Oncotarget, Nov 2015
Inhibition of cPLA2α also prevented an accumulation of cyclin D1/CDK4, cyclin E/CDK2, phospho-pRb, pre-replicative complex proteins CDC6, MCM7, ORC6 and DNA synthesis-related protein PCNA during induction of cell cycle re-entry.
Overexpression and biological function of TMEM48 in non-small cell lung carcinoma.
New
Lin et al., Shanghai, China. In Tumour Biol, Oct 2015
Additionally, real-time PCR and western blot analysis revealed that several cell cycle and DNA replication genes, including Cyclin B1, CDK1, CDC6, PCNA, and RCF4, were reduced after TMEM48 knockdown.
Meier-Gorlin syndrome.
Review
Bongers et al., Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Mutations in one of five genes (ORC1, ORC4, ORC6, CDT1, and CDC6) of the pre-replication complex, involved in DNA-replication, are detected in approximately 67-78% of patients with MGS.
Genome-wide scan for selection signatures in six cattle breeds in South Africa.
Maiwashe et al., South Africa. In Genet Sel Evol, 2014
In addition, a number of candidate genes associated with the nervous system (WNT5B, FMOD, PRELP, and ATP2B), immune response (CYM, CDC6, and CDK10), production (MTPN, IGFBP4, TGFB1, and AJAP1) and reproductive performance (ADIPOR2, OVOS2, and RBBP8) were also detected as being under selection.
MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity.
Review
Narayan et al., Benares, India. In Mol Biol Int, 2013
The six related MCM proteins form a heterohexamer and bind with ORC, CDC6, and Cdt1 to form the prereplication complex.
Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1.
GeneRIF
Masai et al., Tokyo, Japan. In J Biol Chem, 2012
Data show that purified Epstein-Barr nuclear antigen 1 EBNA1 recruits purified Human Orc1 and Cdc6 onto replication origin oriP.
HBx protein of hepatitis B virus promotes reinitiation of DNA replication by regulating expression and intracellular stability of replication licensing factor CDC6.
GeneRIF
Kumar et al., New Delhi, India. In J Biol Chem, 2012
novel role for CDC6 in abetting the oncogenic sabotage carried out by HBx and support the paradigm that pre-replicative complex proteins have a role in oncogenic transformation.
Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
GeneRIF
Okayama et al., Tokyo, Japan. In J Biol Chem, 2012
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation.
GeneRIF
Okayama et al., Tokyo, Japan. In J Biol Chem, 2012
Cdc6 the AAA+ ATPase activated p27-bound Cdk2 in its ATPase and cyclin binding motif-dependent manner but only after the p27 bound to the Cdk2 was phosphorylated at the C terminus.
Cdc6 is required for meiotic spindle assembly in Xenopus oocytes.
GeneRIF
Coué et al., Lubbock, United States. In Cell Cycle, 2012
Cdc6 protein was distributed around the spindle precursor at the time of germinal vesicle breakdown (GVBD), and localized to the margin of the nascent spindle early in prometaphase.
Archaeal orc1/cdc6 proteins.
Review
Bell, Oxford, United Kingdom. In Subcell Biochem, 2011
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6.
Mechanisms and pathways of growth failure in primordial dwarfism.
Review
Jackson et al., Edinburgh, United Kingdom. In Genes Dev, 2011
Ten genes have now been identified for microcephalic primordial dwarfism, encoding proteins involved in fundamental cellular processes including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC6), DNA damage response (ATR [ataxia-telangiectasia and Rad3-related]), mRNA splicing (U4atac), and centrosome function (CEP152, PCNT, and CPAP).
Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
Impact
Jackson et al., Edinburgh, United Kingdom. In Nat Genet, 2011
We report here that individuals with this disorder show marked locus heterogeneity, and we identify mutations in five separate genes: ORC1, ORC4, ORC6, CDT1 and CDC6.
Linking mitosis with S-phase: Cdc6 at play.
Review
Campbell et al., Pasadena, United States. In Cell Cycle, 2008
The Cdc6 protein (Cdc6p) is one of the essential and highly regulated components of the pre-RC.
Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.
Impact
Zhang et al., New Haven, United States. In Nat Cell Biol, 2003
Once the origin recognition complex (ORC) binds to origins, CDC6 and CDT1 associate with ORC and promote loading of the MCM2-7 proteins onto chromatin, generating the preRC.
Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation.
Impact
Méchali et al., Montpellier, France. In Nature, 2002
Here we identify Cdc6, which is essential for recruiting the minichromosome maintenance (MCM) helicase to the pre-replication complex, as this inducer of DNA synthesis.
Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast.
Impact
Liang et al., Hong Kong, Hong Kong. In Cell, 2002
It functions as a critical link between ORC and other initiation proteins to effect chromatin association of Cdc6p and MCM proteins for the establishment and maintenance of prereplication complexes.
Regulation of premeiotic S phase and recombination-related double-strand DNA breaks during meiosis in fission yeast.
Impact
Nurse et al., London, United Kingdom. In Nat Genet, 2001
We have investigated these possibilities in the fission yeast Schizosaccharomyces pombe and found that core DNA replication initiation proteins used during the mitotic cell cycle, including Cdc18p (budding yeast Cdc6p), Cdc19p (Mcm2p), Cdc21p (Mcm4p) and Orp1p (Orc1p), are also required for premeiotic S phase.
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