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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CDC5 cell division cycle 5-like

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Prp19, CAN, STEP, PRL-1, V1a
Papers on CDC5L
Evaluation of gene expression level of CDC5L and MACC1 in poor prognosis and progression of osteosarcoma.
Ahmadi et al., Khorramābād, Iran. In Tumour Biol, Jan 2016
In the present study, MACC1 and CDC5L mRNA levels in the patients with osteosarcoma were evaluated using quantitative real-time PCR.
Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma.
Tao et al., Nantong, China. In Dig Dis Sci, Dec 2015
BACKGROUND: Cell division cycle 5-like (Cdc5L), as a pre-mRNA splicing factor, is a regulator of mitotic progression.
CEF1/OsMYB103L is involved in GA-mediated regulation of secondary wall biosynthesis in rice.
Wu et al., Hefei, China. In Plant Mol Biol, Nov 2015
In this study, we reported a new rice variety, cef1, showed the culm easily fragile (CEF) without other concomitant phenotypes.
Expression of CDC5L is associated with tumor progression in gliomas.
Wang et al., Nantong, China. In Tumour Biol, Nov 2015
UNASSIGNED: Cell division cycle 5-like (CDC5L) protein is a cell cycle regulator of the G2/M transition and has been reported to participate in the catalytic step of pre-messenger RNA (mRNA) splicing and DNA damage repair.
Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro.
Chung et al., Yilan, China. In Oncol Rep, Oct 2015
Specifically, the up‑ and downregulated genes included CCNE2, associated with DNA damage; ID3, associated with cell survival and 146 genes with a >2- to 3-fold change including the TP53INP1 gene, associated with DNA damage; CDC6, CDCA5, TAKMIP2, CDK14, CDK5, CDCA76, CDC25A, CDC5L and SKP2, associated with cell cycle; the CARD6, ID1 and ID2 genes, associated with cell survival and the BRMS1L, associated with cell migration and invasion.
CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.
Rada et al., New York City, United States. In Nucleic Acids Res, Sep 2015
Here we show that in vitro CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex.
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
COMPASS and METASTROKE Consortia et al., Seattle, United States. In Stroke, Aug 2015
Nominal associations (P<10(-6)) for total or ischemic stroke were observed for 18 variants in or near genes implicated in cell cycle/mRNA presplicing (PTPRG, CDC5L), platelet function (HPS4), blood-brain barrier permeability (CLDN17), immune response (ELTD1, WDFY4, and IL1F10-IL1RN), and histone modification (HDAC9).
Small angle X-ray scattering studies of CTNNBL1 dimerization and CTNNBL1/CDC5L complex.
Kim et al., Taegu, South Korea. In Sci Rep, 2014
The hPrp19/CDC5L complex is a non-snRNP spliceosome complex that plays a key role in the spliceosome activation during pre-mRNA splicing, and CTNNBL1 and CDC5L are essential components of the complex.
Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H.
Xu et al., Beijing, China. In Int J Mol Sci, 2014
In particular, we compared our dataset with a previously published phosphoproteome in a normal liver sample, and the results revealed that a number of proteins in the spliceosome pathway, such as U2 small nuclear RNA Auxiliary Factor 2 (U2AF2), Eukaryotic Initiation Factor 4A-III (EIF4A3), Cell Division Cycle 5-Like (CDC5L) and Survival Motor Neuron Domain Containing 1 (SMNDC1), were exclusively identified as phosphoproteins only in the MHCC97-H cell line.
Effects of GnRH antagonist on endometrial protein profiles in the window of implantation.
Liu et al., Nanjing, China. In Proteomics, 2014
Immunohistochemical staining showed that ANPEP was mainly localized in the human endometrial stroma, while ACO2, CDC5L, and GNAS were mainly localized in the glands.
Mutations in 12 known dominant disease-causing genes clarify many congenital anomalies of the kidney and urinary tract.
Hildebrandt et al., Boston, United States. In Kidney Int, 2014
These mutations include (number of families): BMP7 (1), CDC5L (1), CHD1L (5), EYA1 (3), GATA3 (2), HNF1B (6), PAX2 (5), RET (3), ROBO2 (4), SALL1 (9), SIX2 (1), and SIX5 (1).
The PSO4 protein complex associates with replication protein A (RPA) and modulates the activation of ataxia telangiectasia-mutated and Rad3-related (ATR).
Huang et al., Hangzhou, China. In J Biol Chem, 2014
The PSO4 core complex is composed of PSO4/PRP19/SNEV, CDC5L, PLRG1, and BCAS2/SPF27.
Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.
Kim et al., Taegu, South Korea. In Acta Crystallogr D Biol Crystallogr, 2014
The hPrp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome.
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
Zielenska et al., Toronto, Canada. In Plos One, 2013
Five genes, from this panel, which encoded the bone differentiation regulator RUNX2, the cell cycle regulator CDC5L, the TP53 transcriptional inactivator MDM2, the DNA helicase RECQL4, and the cyclin-dependent kinase gene CDK4, were differentially expressed in tumors that responded poorly to neo-adjuvant chemotherapy.
Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.
Li et al., Beijing, China. In Cell Death Dis, 2013
Here, we show that cell division cycle 5-like (Cdc5L), a pre-mRNA splicing factor, is a regulator of mitotic progression.
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
Neuberger et al., Cambridge, United Kingdom. In J Biol Chem, 2011
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
Weinreich et al., Grand Rapids, United States. In J Biol Chem, 2011
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Lamond et al., Dundee, United Kingdom. In Embo Rep, 2010
A central region in hnRNP-M is required for interaction with CDC5L/PLRG1.
Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
Grillari-Voglauer et al., Vienna, Austria. In J Biol Chem, 2009
Blom7alpha is a novel splicing factor of the K homology domain family that might be implicated in alternative splicing by helping to position the CDC5L-SNEV(Prp19-Pso4) complex at the splice sites
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Legerski et al., Houston, United States. In Embo Rep, 2009
These findings show a new function for Cdc5L in the regulation of the ATR-mediated cell-cycle checkpoint in response to genotoxic agents.
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