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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transmembrane protein 30A

CDC50A, TMEM30A, C6orf67
Top mentioned proteins: ATPase, HAD, CAN, OUT, fibrillin-1
Papers on CDC50A
Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium.
New
Nagata et al., Suita, Japan. In J Biol Chem, Feb 2016
As with ATP11C, ATP8A2 and ATP11A localized to the plasma membrane in a CDC50A-dependent manner.
Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit.
New
Andersen et al., Århus, Denmark. In Febs Lett, Jan 2016
Here, we show that in an extensive mutational alanine screening of the mammalian flippase ATP8A2 catalytic subunit, five mutations stand out by leading to reduced glycosylation of the accessory subunit CDC50A.
ATP11C mutation is responsible for the defect in phosphatidylserine uptake in UPS-1 cells.
New
Shin et al., Kyoto, Japan. In J Lipid Res, Nov 2015
By contrast, the level of ATP11A, another PS-flipping P4-ATPase at the plasma membrane, or CDC50A, which is essential for delivery of most P4-ATPases to the plasma membrane, was not affected in UPS-1 cells.
Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.
New
MacDonald et al., Amsterdam, Netherlands. In J Biol Chem, Oct 2015
CDC50A is a protein that forms a heterodimer with P4 ATPases to enhance their translocase catalytic activity.
Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas.
New
O'Neill et al., Brazil. In Clin Cancer Res, Oct 2015
Several genes recurrently affected in PCNSL were common with systemic DLBCL, including loss of TNFAIP3, PRDM1, GNA13, TMEM30A, TBL1XR1, B2M, CD58, activating mutations of CD79B, CARD11, and translocations IgH-BCL6.
Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.
New
Shin et al., Kyoto, Japan. In J Biol Chem, Jul 2015
Here, we show that the localization of class 5 P4-ATPases to the plasma membrane (ATP10A and ATP10D) and late endosomes (ATP10B) requires an interaction with CDC50A.
Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs9350591.
Loughlin et al., Newcastle upon Tyne, United Kingdom. In Bmc Med Genet, 2014
In addition, we identified expression quantitative trait loci (eQTLs) operating on COL12A1, TMEM30A, SENP6 and MYO6, although these were not relevant to the OA associated signal.
The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.
Paulusma et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2014
Moreover, we show that endogenous ATP8B1 exists in a functional heterodimer with transmembrane protein 30A (CDC50A) in Caco-2 cells.
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.
Impact
Nagata et al., Kyoto, Japan. In Science, 2014
Using a haploid genetic screen in human cells, we found that ATP11C (adenosine triphosphatase type 11C) and CDC50A (cell division cycle protein 50A) are required for aminophospholipid translocation from the outer to the inner plasma membrane leaflet; that is, they display flippase activity.
Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.
Umeda et al., Kyoto, Japan. In J Biol Chem, 2013
In Chinese hamster ovary (CHO) cells, at least eight members of P4-ATPases were identified, but only a single CDC50 family protein, CDC50A, was expressed.
MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells.
Zhou et al., Chicago, United States. In Plos One, 2012
Confirmation experiments and functional analyses were performed to further assess 6 selected miR-99 target genes, including mammalian Target of rapamycin (mTOR), Homeobox A1 (HOXA1), CTD small phosphatase-like (CTDSPL), N-myristoyltransferase 1 (NMT1), Transmembrane protein 30A (TMEM30A), and SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5).
Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells.
Stanimirovic et al., Ottawa, Canada. In Fluids Barriers Cns, 2012
Finally, brain endothelial cell extracellular microvesicles were shown to contain several receptors previously shown to carry macromolecules across the blood brain barrier, including transferrin receptor, insulin receptor, LRPs, LDL and TMEM30A.
P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth.
Ding et al., Shanghai, China. In Febs Lett, 2012
Inducing the loss of function of CDC50A in hippocampal neurons via RNA interference reduced neurite outgrowth, and the co-overexpression of CDC50A and ATP8A2 in PC12 cells enhanced NGF-induced neurite outgrowth.
Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases.
Paulusma et al., Amsterdam, Netherlands. In J Histochem Cytochem, 2012
This study analyzed the tissue distribution and cellular localization of CDC50A, the most abundant and ubiquitously expressed CDC50 homologue in the mouse.
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
Shin et al., Kyoto, Japan. In J Biol Chem, 2011
Here, we show that class 5 (ATP10A, ATP10B, and ATP10D) and class 6 (ATP11A, ATP11B, and ATP11C) P4-ATPases require CDC50 proteins, primarily CDC50A, for their exit from the endoplasmic reticulum (ER) and final subcellular localization.
Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2.
GeneRIF
Molday et al., Vancouver, Canada. In J Biol Chem, 2011
CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2
Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cells.
GeneRIF
McIntyre et al., Cleveland, United States. In J Immunol, 2011
Import of choline phospholipids into Saccharomyces cerevisiae DeltaLem3 vector is partially reconstituted by human TMEM30a and by Lem3p-TMEM30a chimeras, showing that the proteins are orthologous.
CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.
GeneRIF
Gamarro et al., Granada, Spain. In Biochem Pharmacol, 2010
CDC50A plays a key role in perifosine uptake in human cells, presumably by forming a functional plasma membrane translocator.
ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.
GeneRIF
Oude Elferink et al., Amsterdam, Netherlands. In Hepatology, 2008
CDC50A may be the potential beta-subunit or chaperone for ATP8B1 in hepatocytes.
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