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Cell division cycle 42

Cdc42
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, Actin, Akt, Rac1, RhoA
Papers using Cdc42 antibodies
CXCR4 and cancer.
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Aziz Syed A., In PLoS ONE, 2011
... (Santa Cruz, CA, USA), anti-human Rac1 from BD Pharmingen (San Jose, CA, USA) and anti-human Cdc42 antibody was obtained from Cell Signaling (Danvers, MA, USA) ...
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity
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Martín-Belmonte Fernando et al., In The Journal of Cell Biology, 2007
... Antibodies against ITSN2 (Novus Biologicals), N-WASP (Santa Cruz Biotechnology, Inc.), Cdc42 (BD), pericentrin (Covance), mLGN/GPSM2/AGS3 (Abnova), α-tubulin (Sigma-Aldrich), γ-tubulin (Sigma-Aldrich), ...
Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.
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Gullberg Donald, In PLoS ONE, 2006
... Anti-Cdc42 antibody was purchased from BD Biosciences and anti-PAK and p-PAK1/2, ...
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis
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Arkowitz Robert Alan, In PLoS ONE, 2005
... Polyclonal anti-pPAK1/2 (Thr423/Thr402), polyclonal anti-IQGAP1, polyclonal anti-N-WASP(30D10), polyclonal anti-PAK1, and monoclonal anti phospho-Rac1/Cdc42 (Ser71) were from Cell Signaling, Germany; monoclonal anti-IQGAP2 (Clone ...
Syndecan-4–dependent Rac1 regulation determines directional migration in response to the extracellular matrix
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Humphries Martin J. et al., In The Journal of Cell Biology, 2005
... antibodies raised against vinculin (Sigma-Aldrich), syndecan-4 (clone 5G9; Santa Cruz Biotechnology, Inc.), and Rac1 and Cdc42 (Becton Dickinson) were used according to ...
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Papers on Cdc42
Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction.
New
Tam et al., Columbus, United States. In Biol Open, Feb 2016
In this study we examined the role of Cdc42 in foregut development and organ bud formation.
Activation of dickkopf-1 and focal adhesion kinase pathway by tumour necrosis factor α induces enhanced migration of fibroblast-like synoviocytes in rheumatoid arthritis.
New
Kim et al., Taegu, South Korea. In Rheumatology (oxford), Jan 2016
Moreover, migrating FLSs exhibited significantly higher levels of FAK, p-JNK, paxillin and cdc42 expression, whereas the level of cytosolic β-catenin was lower.
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
New
Kosaki et al., Tokyo, Japan. In Am J Med Genet A, Jan 2016
UNASSIGNED: We previously documented a girl with macrothrombocytopenia and developmental delay who carried a de novo mutation in CDC42, which plays pivotal roles in the cell cycle and the formation of the actin cytoskeleton.
Mutations of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene Cause a Monocyte-selective Adhesion Deficiency.
New
Laudanna et al., Verona, Italy. In Am J Respir Crit Care Med, Jan 2016
Finally, signal transduction analysis showed that in CF monocytes chemoattractant-triggered activation of RhoA and CDC42 rho small GTPases, controlling integrin activation and chemotaxis respectively, was strongly deficient.
Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes.
New
Kakkar et al., Bengaluru, India. In J Genet, Dec 2015
Expression of EGR1/2/3, IL8, CXCL1, PTGS2, CD69, IFNG, FASLG, CCL4, CDC42, DDX58, NFKBID and NR4A2 genes were independently validated; EGR1/2/3 and IL8 showed >8-fold higher expression in cases relative to the controls implying their important role in CAD.
Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42.
New
Impact
Hsu et al., Boston, United States. In Nature, Jun 2015
Moreover, the small GTPase CDC42 regulates bidirectional Golgi transport by targeting the dual functions of COPI in cargo sorting and carrier formation.
The role of BUB and CDC proteins in low-grade breast cancers.
New
Impact
Ellis et al., Nottingham, United Kingdom. In Lancet, Mar 2015
Additionally, other CDC kinase genes (CDC42) are associated with luminal A breast cancers with good prognosis.
A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction.
Review
New
Gunst et al., Indianapolis, United States. In Can J Physiol Pharmacol, Feb 2015
Contractile stimulation of ASM induces the recruitment and assembly of paxillin, vinculin, and focal adhesion kinase (FAK) into membrane adhesion complexes (adhesomes) that regulate actin polymerization by catalyzing the activation of cdc42 GTPase by the G-protein-coupled receptor kinase-interacting target (GIT) - p21-activated kinase (PAK) - PAK-interacting exchange factor (PIX) complex.
CDC42 Use in Viral Cell Entry Processes by RNA Viruses.
Review
Dittmar et al., London, United Kingdom. In Viruses, 2014
The Rho family GTPase Cdc42 is appreciated as a key moderator of cellular actin dynamics, and the development of specific Cdc42-inhibiting agents has given us an unprecedented ability to investigate its individual role in signalling pathways.
Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss.
Review
Dong et al., Hohhot, China. In Med Microbiol Immunol, 2014
Western blots and immunohistochemical assays showed that brain levels of PAK3 and PAK1, as well as their upstream activator Rac/cdc42 and downstream substrate Raf1, were remarkably reduced at terminal stage.
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.
Impact
Lifton et al., New Haven, United States. In Nat Genet, 2014
Eight tumors (including three carcinomas) had many somatic copy number variants (CNVs) with frequent deletion of CDC42 and CDKN2A, amplification of 5q31.2 and protein-altering mutations in TP53 and RB1.
Systems biology of megakaryocytes.
Review
Kaushansky et al., Seattle, United States. In Adv Exp Med Biol, 2013
Additional signals activated by these secondary mediators include mammalian target of rapamycin; β(beta)-catenin; the G proteins Rac1, Rho, and CDC42; several transcription factors, including hypoxia-inducible factor 1α(alpha), the homeobox-containing proteins HOXB4 and HOXA9, and a number of signaling mediators that are reduced, including glycogen synthase kinase 3α(alpha) and the FOXO3 family of forkhead proteins.
Interaction of LRRK2 with kinase and GTPase signaling cascades.
Review
Wolozin et al., Boston, United States. In Front Mol Neurosci, 2013
Binding to GTPases, GTPase-activating proteins and GTPase exchange factors are another strong theme in LRRK2 biology, with LRRK2 binding to rac1, cdc42, rab5, rab7L1, endoA, RGS2, ArfGAP1, and ArhGEF7.
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
Impact
Downward et al., London, United Kingdom. In Cell, 2013
Unexpectedly, RAS is unable to interact with p110β, but instead RAC1 and CDC42 from the RHO subfamily of small GTPases bind and activate p110β via its RBD.
Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.
Impact
Bäumler et al., Davis, United States. In Nature, 2013
Activation of RAC1 and CDC42 by bacterial delivery or ectopic expression of SopE, a virulence factor of the enteric pathogen Salmonella, triggered the NOD1 signalling pathway, with consequent RIP2 (also known as RIPK2)-mediated induction of NF-κB-dependent inflammatory responses.
Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.
GeneRIF
Hivroz et al., Paris, France. In J Immunol, 2012
Cdc42 controls actin depletion at the immunological synapse.
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
GeneRIF
Balda et al., London, United Kingdom. In J Cell Biol, 2012
Epithelial junction formation and morphogenesis require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics.
Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.
GeneRIF
Birchmeier et al., Berlin, Germany. In Genes Dev, 2012
Cofilin activation during late cortical development depended on NOMA-GAP expression and subsequent inhibition of Cdc42. In utero expression of active cofilin was sufficient to restore postnatal dendritic complexity in NOMA-GAP-deficient animals.
Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3.
GeneRIF
Gomes et al., Paris, France. In Embo Rep, 2012
The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin complex, and requires Cdc42, Par6 and Par3.
Cooperative activation of PI3K by Ras and Rho family small GTPases.
GeneRIF
Heo et al., Taejŏn, South Korea. In Mol Cell, 2012
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities
More papers using Cdc42 antibodies
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes
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Ridley Anne J. et al., In The Journal of Cell Biology, 2002
... Williams, Children’s Hospital, Boston, MA), rabbit anti-Cdc42 and anti-pS19-MLC (Cell Signaling Technology), mouse anti-RhoE as ...
Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts
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Aumailley M. et al., In Cellular and Molecular Life Sciences, 2000
... transfected with the cDNA coding for CA forms of RhoA (RhoA-Q63L), Rac1 (Rac1-Q61L) and Cdc42 (Cdc42-Q61L) in pIRESpuro vector (Clontech, Palo Alto, Calif.) were ...
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells
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Barber Diane L. et al., In The Journal of Cell Biology, 2000
... Precipitated proteins were separated by 12% SDS-PAGE and immunoblotted with anti-Cdc42 antibodies (1:200; BD Biosciences).
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation
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Waldhoer Maria et al., In Cell research, 1997
... Rabbit monoclonal anti-Cdc42 antibody was from Cell Signaling (Austria) ...
Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
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Ridley Anne J. et al., In The Journal of Cell Biology, 1996
... fluorescein-labeled goat anti–mouse secondary antibodies were obtained from Jackson ImmunoResearch Laboratories; anti–c-myc (9E10), anti-RhoA, and anti-Cdc42 monoclonal antibodies were obtained from Santa Cruz Biotechnology, Inc.; Moviol, ML-7, and ...
Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells
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Sonnenberg Arnoud et al., In The Journal of Cell Biology, 1996
... Mouse anti-RhoA (26C4) and rabbit anti-Cdc42 antibodies were obtained from Santa Cruz Biotechnology, and mouse anti-Rac1 antibody ...
Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides
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Nakamura Toshikazu et al., In The Journal of Cell Biology, 1989
... Anti-HA (Y-11), anti-Myc (A-14), anti-Cdc42 (SC-87) polyclonal antibody, and rhodamine-conjugated phalloidin were purchased from Santa Cruz Biotechnology and Molecular Probes, Inc ...
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