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CDC36 Cdc36p

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: NotI, NOT3, CAN, POLYMERASE, HAD
Papers on CDC36
Cross-platform assessment of genomic imbalance confirms the clinical relevance of genomic complexity and reveals loci with potential pathogenic roles in diffuse large B-cell lymphoma.
Houldsworth et al., Rutherford, United States. In Leuk Lymphoma, Dec 2015
Application of these criteria to independent datasets revealed novel candidate genes with coordinated expression, such as CNOT2, potentially with pathogenic roles.
CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARx03B3;, CEBPα and Inhibition of P-GSK3α/β and β-Catenin.
Kim et al., In Cell Physiol Biochem, 2014
BACKGROUND/AIMS: Though CCR4-NOT2 (CNOT2), one of CCR4-NOT complex subunits, was known to be involved in metastasis and apoptosis through transcription and mRNA degradation, its other biological function is poorly understood so far.
The CAF1-NOT complex of trypanosomes.
Clayton et al., Heidelberg, Germany. In Front Genet, 2013
The trypanosome CAF1-NOT complex is simpler than that of other organisms, with no CCR4 or NOT4 homolog: it consists of CAF1, NOT1, NOT2, NOT5 NOT9, NOT10, and NOT11.
Structure and assembly of the NOT module of the human CCR4-NOT complex.
Izaurralde et al., Tübingen, Germany. In Nat Struct Mol Biol, 2013
We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance.
El-Naggar et al., Houston, United States. In Am J Pathol, 2013
(NUMA1) in MEC, and 6p21.1 (CCND3), 9p13.2 (PAX5), 12q15 (CNOT2/RAB3IP), 12q21.1 (GLIPR1L1), and 17q12 (ERBB2/CCL4) in SDC.
NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis.
Cao et al., Beijing, China. In Plant Cell, 2013
NOT2 was identified by its interaction with the Piwi/Ago/Zwille domain of DICER-LIKE1 (DCL1), an interaction that is conserved between rice (Oryza sativa) and Arabidopsis thaliana.
NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.
Izaurralde et al., Tübingen, Germany. In Rna Biol, 2013
The conserved core of the complex is assembled by the interaction of at least two modules: the NOT module, which minimally consists of NOT1, NOT2 and NOT3, and a catalytic module comprising two deadenylases, CCR4 and POP2/CAF1.
The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.
Weichenrieder et al., Tübingen, Germany. In Nucleic Acids Res, 2012
The conserved core of the complex consists of a catalytic module comprising two deadenylases (CAF1/POP2 and CCR4a/b) and the NOT module, which contains at least NOT1, NOT2 and NOT3.
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
Izaurralde et al., Tübingen, Germany. In Nucleic Acids Res, 2012
However, only AIN-1 interacts with C. elegans and D. melanogaster PABPC1, PAN3, NOT1 and NOT2, suggesting that AIN-1 and AIN-2 are functionally distinct.
Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
Hu et al., United States. In Stem Cells, 2012
Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs.
Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae.
Jensen et al., Århus, Denmark. In Rna, 2011
report that four subunits of the Ccr4-Not complex-Ccr4p, Pop2p, Not2p, and Not4p-severely impact HSP104 RNA transcription site-associated retention induced by MFT1 gene deletion
Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.
Yokoyama et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
Furthermore, CNOT2, 3, 6, and 8 were rapidly downregulated during differentiation of neural stem cells.
CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.
Yamamoto et al., Tokyo, Japan. In Genes Cells, 2011
human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability.
Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.
Timmers et al., Utrecht, Netherlands. In Biochem J, 2006
This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification.
The cyclin-dependent kinase 11 interacts with NOT2.
Nelson et al., Tucson, United States. In Biochem Biophys Res Commun, 2005
These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
Estrogen can regulate the cell cycle in the early G1 phase of yeast by increasing the amount of adenylate cyclase mRNA.
Kurata et al., Tokyo, Japan. In Cell, 1989
However, estrogen had no effect on late G1 arrest induced by the alpha factor or ts mutation of cdc36.
[Control of the cell division cycle and sporulation in Saccharomyces cerevisiae by the cyclic AMP system].
Camonis et al., In Biochimie, 1985
CDC36 is partly homologous with the oncogene ets.
A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26.
Reed et al., In Nature, 1984
We report here significant primary sequence homology among the predicted translational products of three genes: CDC4 , CDC36 and ets.
Mating factor dependence of G1 cell cycle mutants of Saccharomyces cerevisiae.
Carter et al., Dublin, Ireland. In Curr Genet, 1983
It is likely that the nature of the primary growth defect in cdc36 and cdc39 mutants is such that the α-factor pathway is activated in the absence of the pheromone at the restrictive temperature and that G1 arrest is a secondary consequence of a non-cycle specific event in such mutants.
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