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Cell division cycle 34 homolog

Cdc34, Ubc3, Cdc34p
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, SCF, CAN, PCNA, Cullin
Papers on Cdc34
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Zarogiannis et al., Lárisa, Greece. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.
Komander et al., Cambridge, United Kingdom. In Embo J, Mar 2015
Notably, UBE2R1- (CDC34), UBE2N/UBE2V1- (UBC13/UEV1A), TRAF6- and HOIP-mediated chain assembly is inhibited by phosphoUb.
Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.
Kay et al., Chicago, United States. In Int J Mol Sci, 2014
We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins: ubiquitin-conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen-activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11).
Cluster of differentiation 166 (CD166) regulates cluster of differentiation (CD44) via NF-κB in liver cancer cell line Bel-7402.
Wang et al., Shanghai, China. In Biochem Biophys Res Commun, 2014
And it may be through E3 ubiquitin ligases COP1 and UBC3 to regulate CD166 protein degradation.
A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.
Hess et al., Ann Arbor, United States. In J Biol Chem, 2013
Here we show that the second PHD finger (PHD2) of MLL1 is an E3 ubiquitin ligase in the presence of the E2-conjugating enzyme CDC34.
The N-terminus of Vps74p is essential for the retention of glycosyltransferases in the Golgi but not for the modulation of apical polarized growth in Saccharomyces cerevisiae.
Lee et al., Taipei, Taiwan. In Plos One, 2012
Genetic analysis has shown that Vps74p is required for the formation of abnormal elongated buds in cdc34-2 cells.
Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.
Schulman et al., Memphis, United States. In Mol Cell, 2012
Structural and biochemical analyses reveal that GLMN adopts a HEAT-like repeat fold that tightly binds the E2-interacting surface of RBX1, inhibiting CRL-mediated chain formation by the E2 CDC34.
Selective recruitment of an E2~ubiquitin complex by an E3 ubiquitin ligase.
Shaw et al., London, Canada. In J Biol Chem, 2012
RING-box protein 1 (Rbx1/ROC1) is a key protein found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase complex that functions with the E2 ubiquitin conjugating enzyme CDC34.
Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28.
Cho et al., Ulsan, South Korea. In Nucleic Acids Res, 2012
Tristetraprolin promotes an increase in expression of mature let-7, which leads to the inhibition of let-7 target gene CDC34 expression and suppresses cell growth.
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
King et al., Boston, United States. In Nat Cell Biol, 2012
Data show that anaphase-promoting complex or cyclosome (APC/C)-mediated multiple monoubiquitylation targeting cyclin B1 for degradation.
Stuck in the middle: drugging the ubiquitin system at the e2 step.
King et al., Boston, United States. In Cell, 2011
The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al.
Association of the disordered C-terminus of CDC34 with a catalytically bound ubiquitin.
Shaw et al., London, Canada. In J Mol Biol, 2011
work provides the first structural details that show how the C-terminus of CDC34 might direct a thiolester-bound Ub to control polyubiquitin chain formation
New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1.
Goebl et al., Indianapolis, United States. In Genetics, 2011
Through analysis of the phenotype of a mutant missing a highly conserved sequence motif within the catalytic domain of Cdc34, we discovered previously unrecognized levels of regulation
Nutrient sensing kinases PKA and Sch9 phosphorylate the catalytic domain of the ubiquitin-conjugating enzyme Cdc34.
Goebl et al., Indianapolis, United States. In Plos One, 2010
Cdc34 phosphorylation by PKA and Sch9 provides a direct tether between G1 cell division events and cell growth
Degradation-mediated protein quality control in the nucleus.
Gottschling et al., Seattle, United States. In Cell, 2005
It is defined by San1p, a ubiquitin-protein ligase that, in conjunction with the ubiquitin-conjugating enzymes Cdc34p and Ubc1p, targets four distinct mutant nuclear proteins for ubiquitination and destruction by the proteasome.
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
Deshaies et al., Pasadena, United States. In Cell, 1997
In S. cerevisiae, the G1/S transition requires Cdc4p, Cdc34p, Cdc53p, Skp1p, and the Cln/Cdc28p cyclin-dependent kinase (Cdk).
Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase.
Deshaies et al., Pasadena, United States. In Science, 1997
A Sic1p mutant lacking three Cdk phosphorylation sites did not serve as a substrate for Cdc34p-dependent ubiquitination in vitro, was stable in vivo, and blocked DNA replication.
Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle.
Kirschner et al., Boston, United States. In Science, 1997
The cell division cycle gene, CDC34, is required for ubiquitin-mediated degradation of G1 regulators and cell cycle progression through the transition from G1 to S phase in budding yeast.
How proteolysis drives the cell cycle.
Kirschner et al., Boston, United States. In Science, 1997
One pathway, requiring CDC34, initiates DNA replication by degrading a CDK inhibitor.
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