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Cell division cycle 27 homolog

Cdc27, APC3
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, Ubiquitin, PCNA, CAN, HAD
Papers using Cdc27 antibodies
Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.
Mossman Karen L., In PLoS Pathogens, 2010
Covance); anti-GFP (3E6 and A6455, Invitrogen); anti-APC3 (AF3.1,
Proteomic analysis of tardigrades: toward a better understanding of molecular mechanisms by anhydrobiotic organisms.
Arkowitz Robert Alan, In PLoS ONE, 2009
... AB-2), anti-cyclin D (sc-HD11), anti-Cdk1 phospho-specific (Calbiochem), anti-Cdc25A (sc F-6), anti-Cdc25B (sc C-20), anti-Cdc25C (sc C-20), anti-APC3/Cdc27 (BD Biosciences), anti-tubulin (Sigma B-5-1-2), and ...
Papers on Cdc27
Association between polymorphisms in cdc27 and breast cancer in a Chinese population.
Huang et al., Wuhan, China. In Tumour Biol, Jul 2015
Cdc27, as a core component of anaphase-promoting complex (APC), is a cell cycle regulator, which participates in control of mitotic checkpoint and surveys the mitotic spindle to maintain chromosomal integrity.
Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
Schulman et al., Memphis, United States. In J Mol Biol, May 2015
The Arc Lamp contains the small subunits APC16, CDC26, and APC13, and tetratricopeptide repeat (TPR) proteins (APC7, APC3, APC6, and APC8) that homodimerize and stack with quasi-2-fold symmetry.
Bicluster and pathway enrichment analysis related to tumor progression of hepatocellular carcinoma.
Meng et al., Shanghai, China. In Eur Rev Med Pharmacol Sci, Apr 2015
RESULTS: Our analysis indicated that several differentially expressed genes might play crucial roles in the progression of hepatocellular carcinoma, such as GADD45G, SPTBN1, CDC27, TPD52 and INSIG1.
Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.
Carling et al., Stockholm, Sweden. In J Clin Endocrinol Metab, Mar 2015
Genes with potential disease-causing mutations included GNAS, NF2, and RB1, and recurrently mutated genes with unknown roles in tumorigenesis comprised CDC27, SCN7A, and SDK1.
Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.
Almeida et al., Salamanca, Spain. In Sci Rep, 2014
Here, we show that activation of glutamatergic receptors in rat cortical primary neurons endogenously triggers cyclin-dependent kinase-5 (Cdk5)-mediated phosphorylation of Cdh1 leading to its cytoplasmic accumulation and disassembly from the APC3 core protein, causing APC/C inactivation.
MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.
Han et al., Handan, China. In Med Sci Monit, 2014
Dual luciferase assay was performed to verify a putative downstream target of miR-27a, CDC27.
Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.
Turnbull et al., London, United Kingdom. In Nat Commun, 2014
In addition to expected copy number gain of chromosome 12p and mutation of KIT, we identify recurrent mutations in the tumour suppressor gene CDC27 (11.9%).
Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.
Luo et al., Beijing, China. In Sci Rep, 2014
We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population.
EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.
Gu et al., Guangzhou, China. In Sci Rep, 2013
Microarray analysis revealed that 100 genes, including CDKN1C, CDC27 and PRKDC, changed their mRNA expressions with the increase of EGR1 and contributed to intervention of tumor progression.
Whole exome sequencing of a single osteosarcoma case--integrative analysis with whole transcriptome RNA-seq data.
Märtson et al., Tartu, Estonia. In Hum Genomics, 2013
Additionally, the mucin family genes, especially MUC4 and cell cycle controlling gene CDC27 may be considered as potential biomarkers for OS.
Molecular basis for the association of microcephalin (MCPH1) protein with the cell division cycle protein 27 (Cdc27) subunit of the anaphase-promoting complex.
Couch et al., Rochester, United States. In J Biol Chem, 2012
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1-APC/C.
Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.
Wan et al., Pittsburgh, United States. In J Biol Chem, 2011
phosphorylation of Cdc27 by CKII is involved in TGF-beta-induced activation of APC.
How APC/C-Cdc20 changes its substrate specificity in mitosis.
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression.
Sterneck et al., Frederick, United States. In Proc Natl Acad Sci U S A, 2010
Cdc27 directs cyclin D1 to alternative degradation by anaphase promoting complex/cyclosome.
The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.
Goldberg et al., Jerusalem, Israel. In J Biol Chem, 2007
The interaction is direct and is mediated by the tandem BRCA1 C-terminal domains of MDC1 and the C terminus of the Cdc27 (APC3) subunit of the anaphase-promoting complex/cyclosome.
Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen.
Rosenberg et al., Bethesda, United States. In Science, 1999
This led to the identification of a mutated form of human CDC27, which gave rise to an HLA-DR4-restricted melanoma antigen.
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Science, 1998
The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).
Identification of BIME as a subunit of the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Science, 1996
In addition to CDC27, CDC16, and CDC23, APC contained a homolog of Aspergillus nidulans BIME, a protein essential for anaphase.
The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle.
Roberts et al., Seattle, United States. In Cell, 1996
CDC16 and CDC27 were identified as genes in S. cerevisiae necessary to limit DNA replication to once per cell cycle.
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