The control of meiotic maturation in mammalian oocytes.
Newcastle, Australia. In Curr Top Dev Biol, 2012
This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together.
Cell cycle in ascidian eggs and embryos.
Villefranche-sur-Saône, France. In Results Probl Cell Differ, 2010
Meta II-CSF is mediated by the Mos/MEK/MAPK/Erp1 pathway, which inhibits the ubiquitin ligase APC/C(cdc20) preventing cyclin B destruction thus stabilizing MPF activity.