gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cell division cycle 20 homolog

Cdc20, p55CDC, Cdc20p
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, PCNA, Ubiquitin, CAN, E-cadherin
Papers using Cdc20 antibodies
The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
Supplier
Kiyokawa Hiroaki et al., In The Journal of Cell Biology, 1998
... Antibodies against Mad2 and Cdc20 were purchased from Santa Cruz Biotechnology, Inc ...
Papers on Cdc20
Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells.
New
Chung et al., Taiwan. In Environ Toxicol, Jan 2016
The cell-division cycle protein 20 (CDC20), Budding uninhibited by benzimidazole 1 homolog beta (BUB1B), and cyclin B1 were downregulated, and clusterin was upregulated in GBM 8401 cells treated with PEITC.
Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
New
Zhang et al., Durham, United States. In Cell Cycle, Jan 2016
Early in mitosis, the mitotic checkpoint complex (MCC) inactivates the APC/C by binding the APC/C activating protein CDC20 until the chromosomes are properly aligned and attached to the mitotic spindle, at which point MCC disassembly releases CDC20 to activate the APC/C.
Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation.
New
Wang et al., Shanghai, China. In Plant Cell, Dec 2015
The SAC proteins regulate mitotic chromosome segregation by affecting CDC20 (Cell Division Cycle 20) function.
Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling.
New
Hayward et al., Baltimore, United States. In Plos Pathog, Dec 2015
Furthermore, we demonstrated that BGLF4 binds to and directly phosphorylates the key cellular proteins PP1, MPS1 and CDC20 that lie upstream of SAC activation and APC/C inhibition.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
New
Impact
Pines et al., Cambridge, United Kingdom. In Nature, Mar 2015
The SAC prevents the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase from recognizing cyclin B and securin by catalysing the incorporation of the APC/C co-activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).
Role of NSC319726 in ovarian cancer based on the bioinformatics analyses.
Wang et al., Jilin, China. In Onco Targets Ther, 2014
Additionally, in the protein-protein interaction network and subnetwork, cyclin B1 (CCNB1) and cell division cycle 20 (CDC20) were hub genes, which were also involved in the functions related to mitotic cell cycle.
The control of meiotic maturation in mammalian oocytes.
Review
Jones et al., Newcastle, Australia. In Curr Top Dev Biol, 2012
This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together.
Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex.
GeneRIF
Hershko et al., Haifa, Israel. In Proc Natl Acad Sci U S A, 2012
The binding of p31(comet) to Mad2 in the mitotic checkpoint complex may trigger a conformational change in Cdc20 that facilitates its phosphorylation by Cdk, and that the latter process may promote its dissociation from BubR1.
Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases.
GeneRIF
Kim et al., Suwŏn, South Korea. In Mol Cancer Res, 2012
APC/C(Cdc20) or APC/C(Cdh1) complexes regulate RAP80 stability during mitosis to the G(1) phase, and these events are critical for a novel function of RAP80 in mitotic progression.
Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20.
GeneRIF
Behrens et al., Erlangen, Germany. In Embo Rep, 2012
CDC20-mediated degradation of conductin regulates Wnt/beta-catenin signalling for maximal activity during G1/S.
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
Impact
Sen et al., Houston, United States. In Cancer Cell, 2012
Aurora-A phosphorylated p73 also facilitates inactivation of SAC through dissociation of the MAD2-CDC20 complex in cells undergoing mitosis.
Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression.
GeneRIF
Wang et al., Houston, United States. In J Hematol Oncol, 2011
Aberrant CDC20 expression may play an important role in pancreatic ductal adenocarcinoma tumorigenesis and progression and may thus be useful as a marker of disease progression and prognosis and as a therapeutic target.
Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.
GeneRIF
Grieco et al., Napoli, Italy. In Nat Commun, 2011
Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Impact
Deng et al., Bethesda, United States. In Cancer Cell, 2011
We demonstrated that SIRT2 regulates the anaphase-promoting complex/cyclosome activity through deacetylation of its coactivators, APC(CDH1) and CDC20.
APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Impact
GeneRIF
Pines et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
Anaphase promoting complex subunit 15(APC15) mediates the constant turnover of CDC20 and mitotic checkpoint protein complexes, allowing the spindle checkpoint assembly to respond to the attachment state of kinetochores.
Transcriptomic network analysis of micronuclei-related genes: a case study.
Review
Jennen et al., Maastricht, Netherlands. In Mutagenesis, 2011
BAX, DMNT1, PCNA, HIC1, p21 and CDC20, were retrieved.
Cell cycle in ascidian eggs and embryos.
Review
Dumollard et al., Villefranche-sur-Saône, France. In Results Probl Cell Differ, 2010
Meta II-CSF is mediated by the Mos/MEK/MAPK/Erp1 pathway, which inhibits the ubiquitin ligase APC/C(cdc20) preventing cyclin B destruction thus stabilizing MPF activity.
Assessment of the mitotic spindle assembly checkpoint (SAC) as the target of anticancer therapies.
Review
Bolanos-Garcia, Cambridge, United Kingdom. In Curr Cancer Drug Targets, 2009
The recruitment of mitotic checkpoint proteins to kinetochores that are not correctly attached to microtubules initiates a signalling cascade that results in the CDC20-dependent inhibition of the anaphase-promoting complex/cyclosome (APC/C).
The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory.
Impact
Zhang et al., Houston, United States. In Nat Cell Biol, 2008
Cdc20 (fizzy (fzy)) or p55CDC, and Cdh1 (Hct1, srw1 or fizzy-related 1 (fzr1)) encode two adaptor proteins that bring substrates to the APC.
A roller coaster ride with the mitotic cyclins.
Review
Poon et al., Hong Kong, Hong Kong. In Semin Cell Dev Biol, 2005
Destruction of the mitotic cyclins is carried out by the ubiquitin ligases APC/C(CDC20) and APC/C(CDH1).
share on facebooktweetadd +1mail to friends