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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cyclin-dependent kinase 1

CDC2, cyclin-dependent kinase, CDK1
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: PCNA, V1a, p21, CAN, p53
Papers using CDC2 antibodies
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
Supplier
El-Rifai Wael, In PLoS ONE, 2010
... JNK, cleaved- poly (ADP-ribose) polymerase (PARP), p44/42 MAPK (ERK 1/2), phospho-p44/42 MAPK (p-T202, p-Y204) (p-ERK), Cdc2, Ki67, and COX-2 were purchased from Cell Signaling Technology, Inc ...
Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining
Supplier
Padmanabhan Jaya et al., In Molecular Neurodegeneration, 2008
... against Aβ1-16) was from Signet, C-terminal APP antibody was from Chemicon/Millipore, Thr668 P-APP, MPM-2, and P-cdc2 antibodies were from Cell Signaling, and cyclin D1, cyclin ...
Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo.
Supplier
Minna John D., In PLoS ONE, 2008
... The anti-human p53, p21, p27, Caspase-3, Bcl-2, Bax, cyclin A, cyclin E, cyclin D1, cyclin-dependent kinase (Cdk)2 antibodies were from Santa Cruz Biotechnology, Inc ...
Oct4-induced pluripotency in adult neural stem cells.
Supplier
Fimia Gian Maria, In PLoS ONE, 2008
... anti-Bax, anti-cyclin D1, anti-cyclin A, anti-phospho Rb (S807/811), anti-OCT4, anti-rabbit Alexa-conjugate secondary antibody, anti-Pan-actin and anti-phospho-cdc2(Tyr15) were purchased from Cell Signaling Technology (Danvers, MA, USA) ...
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes.
Supplier
Tian Xiuhcun (Cindy), In PLoS ONE, 2007
... CDC2 antibody was purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
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Papers on CDC2
Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases.
Review
New
Dhar et al., Hyderābād, India. In Curr Genet, Feb 2016
In continuation with the recent finding that CDK-like protein PfPK5 regulates important DNA replication protein like origin recognition complex subunit 1 in Plasmodium falciparum, here we have discussed the emerging significance of CDK1/2 homologs in DNA replication of parasitic protozoans.
Multiple Faces of Dynamin-related Protein 1 and Its Role in Alzheimer's Disease Pathogenesis.
Review
New
Hemachandra Reddy et al., Lubbock, United States. In Biochim Biophys Acta, Jan 2016
This article also highlights Drp1 and its relationships to glycogen synthase kinase 3, cyclin-dependent kinase 5, p53, and microRNAs in AD pathogenesis.
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
New
Impact
Roeder et al., New York City, United States. In Science, Jan 2016
Paused Pol II release is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation of DRB sensitivity-inducing factor, negative elongation factor, and C-terminal domain (CTD) serine-2 of Pol II.
Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma.
New
Hsu et al., Taiwan. In Oncol Lett, Dec 2015
However, few studies have investigated the role of cyclin T1 and cyclin-dependent kinase 9 (CDK9) in gastric adenocarcinoma.
Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression.
New
Wu et al., Jishou, China. In Oncol Lett, Dec 2015
Mechanistic investigation revealed that the protein levels of c-myc, a target gene of the Wnt signaling, as well as cyclin D1, cyclin E and cyclin-dependent kinase 4 were markedly reduced in the ROR2-knockdown OS cells, suggesting that the inhibitory effect of ROR2 knockdown on OS cell proliferation is associated with the Wnt signaling pathway.
Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions.
Review
New
Okazaki et al., Hirakata, Japan. In J Clin Med, Dec 2015
As the TGF-β receptors, c-Jun N-terminal kinase and cyclin-dependent kinase, differentially phosphorylate Smad2/3, we have generated numerous antibodies against linker (L) and C-terminal (C) phosphorylation sites in Smad2/3 and identified four types of phosphorylated forms: cytostatic COOH-terminally-phosphorylated Smad3 (pSmad3C), mitogenic pSmad3L (Ser-213) signaling, fibrogenic pSmad2L (Ser-245/250/255)/C signaling and migratory pSmad2/3L (Thr-220/179)/C signaling.
Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.
New
Tessem et al., Provo, United States. In J Diabetes Res, Dec 2015
Using expression analysis to define Nkx6.1-independent mechanisms by which Nr4a1 and Nr4a3 induce β-cell proliferation, we demonstrated that cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1) is upregulated by Nr4a1 and Nr4a3 but not by Nkx6.1.
Expression of Skp2 and p27(kip1) proteins in hypopharyngeal squamous cell carcinoma and its clinical significance.
New
Wu et al., Quanzhou, China. In Oncol Lett, Dec 2015
UNASSIGNED: The aim of the present study was to determine the effect of S-phase kinase-associated protein 2 (Skp2) and cyclin-dependent kinase inhibitor p27(kinase-interacting protein 1) (p27(kip1)) protein expression on the occurrence and development of hypopharyngeal squamous cell carcinoma.
2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.
New
Li et al., Zhenjiang, China. In Oncol Lett, Dec 2015
Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27(Kip1).
Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.
New
Impact
von Dassow et al., Madison, United States. In Nat Cell Biol, Nov 2015
The waves are modulated by cyclin-dependent kinase 1 (Cdk1) activity and require the Rho GEF (guanine nucleotide exchange factor), Ect2.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
New
Impact
Shair et al., Cambridge, United States. In Nature, Nov 2015
Here we show that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
New
Impact
Werb et al., San Francisco, United States. In Nature, Nov 2015
Progression to high metastatic burden was associated with increased proliferation and MYC expression, which could be attenuated by treatment with cyclin-dependent kinase (CDK) inhibitors.
CDK7-dependent transcriptional addiction in triple-negative breast cancer.
New
Impact
Zhao et al., Boston, United States. In Cell, Oct 2015
Utilizing kinase inhibitors and CRISPR/Cas9-mediated gene editing, we show here that triple-negative but not hormone receptor-positive breast cancer cells are exceptionally dependent on CDK7, a transcriptional cyclin-dependent kinase.
Molecular concept in human oral cancer.
Review
Pal et al., Lucknow, India. In Natl J Maxillofac Surg, 2015
Several oncogenes and tumor suppressor genes have been implicated in oral cancer especially cyclin family, ras, PRAD-1, cyclin-dependent kinase inhibitors, p53 and RB1.
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.
Review
Shin et al., Seoul, South Korea. In Int J Mol Sci, 2014
Biochemical studies revealed that the anti-proliferative activity of TOB1 involves mRNA deadenylation and is associated with the reduction of both cyclin D1 and cyclin-dependent kinase (CDK) expressions and the induction of CDK inhibitors.
Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
GeneRIF
Dong et al., Omaha, United States. In Biochem J, 2012
identified KIBRA Ser(542) and Ser(931) as main phosphorylation sites for CDK1 both in vitro and in vivo
Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.
GeneRIF
Wiebusch et al., Berlin, Germany. In J Virol, 2012
Human cytomegalovirus IE1/2 expression was downregulated by cyclin A2, CDK1 and CDK2.
Human cytomegalovirus UL97 kinase alters the accumulation of CDK1.
GeneRIF
Prichard et al., Birmingham, United States. In J Gen Virol, 2012
These results suggest that, in addition to phosphorylating CDK1 targets, the UL97 kinase modifies G/M cell-cycle checkpoint regulators, specifically CDK1, to promote virus replication.
Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
GeneRIF
Hirota et al., Tokyo, Japan. In Dev Cell, 2012
By consecutively acting as a protease and a cdk1 inhibitor, separase coordinates two key processes to achieve simultaneous and abrupt separation of sister chromatids.
Spatial positive feedback at the onset of mitosis.
Impact
GeneRIF
Ferrell et al., Stanford, United States. In Cell, 2012
Study used chemical biology approaches and live-cell microscopy to show that nuclear Cdk1-cyclin B1 promotes the translocation of Cdk1-cyclin B1 to the nucleus.
More papers using CDC2 antibodies
Maintenance of the CD40-related immunodeficient response in hyper-IgM B cells immortalized with a LMP1-regulated mini-EBV.
Supplier
Khan Wasif N., In PLoS ONE, 2004
... Anti-S6 mAb, rabbit polyclonal anti-caspase 4 and rabbit polyclonal anti-phospho-CDC2 were purchased from Cell Signaling.
Cell polarization during monopolar cytokinesis
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Mitchison Timothy J. et al., In The Journal of Cell Biology, 2004
... For Cdk1 inhibition, purvalanol A (Tocris Bioscience) was used at ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Supplier
Di Giovanni Simone, In PLoS ONE, 2003
... sources: polyclonal rabbit anti-CDK1, cyclin B1, cyclin A, Bim, and c-Myb (Santa Cruz Biotechnology), mouse anti-CDK1 (Santa Cruz Biotechnology), mouse anti-E2F1 (BD pharmingenTM), ...
A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates
Supplier
Shapiro Paul et al., In Journal of Cell Communication and Signaling, 2002
... LIN-1 phosphorylation was also examined in the presence of active CDK1 (New England Biolabs).
Polypoloidization and centrosome hyperamplification in inflammatory bronchi
Supplier
Regan J. W. et al., In Cellular and Molecular Life Sciences, 2001
... Cdc2 rabbit polyclonal (C-19) and mouse monoclonal (B-6) antibodies were purchased from Santa Cruz Biotechnology.
Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1
Supplier
Pines Jonathon et al., In The Journal of Cell Biology, 2001
... LMB and Cdk1/2 inhibitor III (5-amino-3-((4-(aminosulfonyl) phenyl) amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide) were purchased from Merck Biosciences ...
The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1999
... Rabbit and mouse anti-Myc antibodies, anti-ubiquitin antibody, and anti-Cdc2 antibody were purchased from Santa Cruz Biotechnology Inc., and were used ...
Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage
Supplier
Shiloh Yosef et al., In The Journal of Cell Biology, 1999
... (5A1), and α–PARP-1 were obtained from Cell Signaling Technology, Inc.; anti-H2B, α-p53 (DO-1), α-Hsc70, and α-Cdc2 p34 were obtained from Santa Cruz Biotechnology, Inc.; α-p21 ...
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